2-(4-甲基苯基)吡啶置于n-溴代丁二酰亚胺(Nbs),偶氮二异丁腈,水,Calcium Carbonate体系中,用 四氯化碳 用作溶剂,化学反应 51.0H,反应生成4-(2-吡啶基)-苯甲醛 参考文献:Synthesis And Properties Of A Dendritic Fret Donor-acceptor System With Cationic Iridium(III) Complex Core And Carbazolyl Periphery 标题:Synthesis And Properties Of A Dendritic Fret Donor-acceptor System With Cationic Iridium(III) Complex Core And Carbazolyl Periphery 摘要:为了增强环金属化铱(III)络合物的光致发光性能,该络合物在生物标记和生物成像中具有潜在应用,研究人员在异配体铱(III)络合物的环金属化cân配体上引入了一系列带有咔唑末端的苄醚支链树状单元.这些络合物还包含一个带有羧基的双齿联吡啶配体,便于进一步的生物共轭或功能化.这些带有咔唑侧基的苄醚树枝状单元展现了双重功能,既作为福尔斯特共振能量转移(Fret)的供体,又能为ir(III)络合物核心提供氧屏蔽.外围的咔唑基团更强烈地吸收紫外光,并通过fret效应有效地将能量转移到ir(III)络合物核心,从而显著增强了ir(III)络合物在约560 Nm处的光致发光.此外,含有咔唑末端的苄醚树枝状聚合物能够屏蔽ir(III)络合物核心,从而减弱氧的猝灭效应,进一步增强了ir(III)络合物的光致发光. Doi:10.1039/c1Dt11716E
专利号:US-4582903-A 优先权日:1984-08-17 标 题 :Synthesis of unsaturated hydantoins with an inexpensive catalyst 发明人:MIRVISS STANLEY B 权利人:STAUFFER CHEMICAL CO 摘要:Alkylidene or arylidene substituted hydantoins are produced by condensation of an aromatic or aliphatic aldehyde with hydantoin in the presence of at least one basic salt of an inorganic acid. The desired products are obtained in high yields.
专利号:US-2010184989-A1 优先权日:2007-03-12 标 题 :De Novo Synthesis of Conjugates 发明人:RIGGS-SAUTHIER JENNIFER; DENG BO-LIANG; REN ZHONGXU; ZHANG WEN; GU XUYUAN; DUARTE FRANCO J 权利人:NEKTAR THERAPEUTICS 摘要:The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.
专利号:EP-3515880-B1 优先权日:2017-03-17 标题:Methods and compositions for synthesis of encoded libraries 发明人:LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN 权利人:HITGEN INC
专利号:US-2020149034-A1 优先权日:2017-03-17 标题:Methods and Compositions for Synthesis of Encoded Libraries
专利号:AU-2008226820-A1 优先权日:2007-03-12 标题 :De novo synthesis of conjugates
专利号:CA-2679473-A1 优先权日:2007-03-12 标题:De novo synthesis of conjugates
参考标题:Diversity Oriented Clicking (Doc): Divergent Synthesis Of Sufexable Pharmacophores From 2‐substituted‐alkynyl‐1‐sulfonyl Fluoride (Sasf) Hubs 作者:Christopher J. Smedley,Gencheng Li,Andrew S. Barrow,Timothy L. Gialelis,Marie‐claire Giel,Alessandra Ottonello,Yunfei Cheng,Seiya Kitamura,Dennis W. Wolan,K. Barry Sharpless,John E. Moses |发布日期:2020.7.20 摘要:Diversity Oriented Clicking (Doc) Is A Unified Click‐approach For The Modular Synthesis Of Lead‐like Structures Through Application Of The Wide Family Of Click Transformations. Doc Evolved From The Concept Of Achieving "Diversity With Ease" , By Combining Classic C−c π‐bond Click Chemistry With Recent Developments In Connective Sufex‐technologies. We Showcase 2‐substituted‐alkynyl‐1‐sulfonyl Fluorides
合成参考文献
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