CAS: 122892-31-3; N-(4-(2-(Dimethylamino)Ethoxy)Benzyl)-3,4-Dimethoxybenzamide Hydrochloride

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CAS号122898-67-3 伊托必利

Ethylamine,N,N-Dimethyl-2-[4-(Chloromethyl)Phenoxy]-置于盐酸,Ammonium Hydroxide,N,N-二异丙基乙胺体系中,用 甲醇,乙醇,甲苯 用作溶剂,化学反应 8.0H,反应生成盐酸依托必利
参考文献:一种盐酸伊托必利的制备方法
标题:一种盐酸伊托必利的制备方法
摘要:一种盐酸伊托必利的制备方法本发明涉及盐酸伊托必利的制备方法,反应以2‑二甲氨基氯乙烷盐酸盐和苯酚为起始物料,经过醚化,氯甲基化,氨基取代,酰胺化,成盐5步反应得到盐酸伊托必利.本发明采用hcl/cho促进的氯甲基化避免了亚胺还原步骤,既消除了还原剂产生的固体废渣,又提高了反应的安全性;所用原料价格便宜,市场供应充足,容易购买;各步反应比较经典,安全易于控制,适合工业化生产.

专利信息

专利号:US-2009177008-A1
优先权日:2005-12-28
标题:Novel process for synthesis of itopride and its novel intermediate n-(4-hydroxybenzyl)- 3,4-dimethoxybenzamide
发明人：KHAMAR BAKULESH MAFATLAL; MODI INDRAVADAN AMBALAL; VENKATRAMAN JAYARAMAN; RAVI PONNAIAH; NORI DIVAKARA SOMAYAJULU; GAJULA MADHUSUDANA RAO; RENUGADEVI GURUSAMY; SHASHIKALA KUNJARU N; RUDRAMUNI SANTOSH M
权利人:CADILA PHARMACEUTICALS LTD
摘要:The present invention relates to a novel and improved process for the preparation of N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide—known as Itopride, via a novel intermediate N-(4Ëœhydroxybenzyl)-3,4-dimethoxybenzamide.

专利号:US-2025259704-A1
优先权日:2022-06-24
标 题:Systems and methods for cell-free iterative site saturation mutagenesis and its application for the directed evolution of enzymes catalyzing unnatural reactions
发明人：JEWETT MICAHEL C; BOGART JONATHAN W; LANDWEHR GRANT M; Karim Ashty Stephen
权利人:UNIV NORTHWESTERN
摘要:Disclosed are methods, compositions, systems, and protein compounds for the directed evolution of enzymes and proteins. The method comprising generating variant protein with a desired functionality, comprising one or more DNA expression templates comprising nucleic acid sequences encoding a variant protein, expressing the variant protein using cell-free protein synthesis; and analyzing one or more parameters associated with the variant protein.

专利号:WO-2007074386-A9
优先权日:2005-12-28
标 题 :A novel process for synthesis of itopride and it’s novel intermediate-n-(4-hydroxybenzyl)-3,4-dimethoxybenzamide

专利号:WO-2007074386-A2
优先权日:2005-12-28
标题 :A novel process for synthesis of itopride and it’s novel intermediate-n-(4-hydroxybenzyl)-3,4-dimethoxybenzamide