专利号:EP-1786841-B1 优先权日:2004-06-25 标 题 :Ultrasound-assisted synthesis of cyclodextrin-based nanosponges 发明人:TROTTA FRANCESCO; CAVALLI R; TUMIATTI WANDER; ZERBINATI ORFEO; ROGGERO CARLO; VALLERO ROBERTO 权利人:SEA MARCONI TECHNOLOGIES SAS 摘要:A description is given of substantially spherical nanosponges which can be obtained by crosslinking cyclodextrins and their by-products with organic carbonates as crosslinkers and ultrasounds without a solvent.
专利号:US-2023139632-A1 优先权日:2020-03-18 标题:Method and device for purifying viscous and/or solid isocyanates from a product flow from isocyanate synthesis 发明人:MORAWSKI JOERG; BELLINGHAUSEN RAINER 权利人:COVESTRO DEUTSCHLAND AG 摘要:The present invention relates to a process for the purification of a product stream from isocyanate synthesis, wherein the isocyanate converted to the gas phase from the product stream is continuously deposited on a rotating cooled roller and removed from the roller. The present invention further relates to an apparatus for the purification of a product stream from isocyanate synthesis, wherein the apparatus has both a heated roller and a condensation roller.
专利号:WO-2024258613-A9 优先权日:2023-06-16 标题:Tetrachlorovancomycin and derivatives 发明人:BOGER DALE 权利人:SCRIPPS RESEARCH INST 摘要:A total synthesis of a new class of vancomycin analogues of reduced synthetic complexity was developed. The synthesis, achieved by the addition of two aryl chloride substituents to provide tetrachlorovancomcyin aglycon (Compound II), tetrachlorovancomcyin (Compound I ), and their derivatives, permitted a streamlined total synthesis of the new class of glycopeptide antibiotics by removing atropisomer stereochemical control and enabled the simultaneous and further activated SNAr macrocyclizations that establish the tricyclic skeleton of Compound I. In addition to the antimicrobial evaluation of tetrachlorovancomycin (Compound I), the preparation of key binding pocket and peripherally-modi fied derivatives, which overcome vancomycin resistance and introduce independent and synergistic mechanisms of action, revealed their exceptional antimicrobial potency and provide the foundation for use of this new class of synthetic glycopeptide analogues. Also disclosed are a pharmaceutical composition containing bactericidal amount of tetrachlorovancomycin, a derivative thereof or a salt of either dissolved or dispersed in a pharmaceutically acceptable diluent.
专利号:WO-0013004-A2 优先权日:1998-08-26 标题:Combinatorial polymer synthesis of sensors for polymer-based sensor arrays
专利号:US-5843386-A 优先权日:1995-04-20 标题 :Hydrothermal reaction apparatus 发明人:MAKINO HISAAKI; MORIYA TAKEHIKO; SAITO YOSHIHISA; KANAZAWA MASAZUMI 权利人:TOHOKU ELECTRIC POWER CO; OHEI DEVELOPMENTAL IND CO INC 摘要:A safe and efficient hydrothermal reaction apparatus is described herein. Decomposition or synthesis of object material is performed by the continuous passing of the material through a flow passage of multi-staged reactor units under turbulent flow conditions. The flow passage is formed by a curved or spiral piping. In each reactor unit, a hot plate block is included as a heating unit. The hot plate block and the curved piping are placed in an appropriate thermal contact relationship. A portion of the curved piping is freely supported, so as to accommodate stress caused in the piping under high-temperature/high-pressure conditions. A tank is provided for regulating or controlling the pressure fluctuation within the flow passage which may be caused by solids or powder present or occurring in the flow passage during high-pressure treatment. A portion of object material which has not been decomposed during the high-pressure treatment is again introduced or returned to the reactor for complete decomposition thereof after the addition of more solvent.
专利号:US-2008213384-A1 优先权日:2004-06-25 标题:Ultrasound-Assisted Synthesis of Cyclodextrin-Based Nanosponges