CAS: 77422-70-9; Azidomethylphenylsulfide

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CAS号7205-91-6 氯甲基苯硫醚 | CAS号35572-08-8 BROMOMETHYL PHE... | CAS号100-68-5 茴香硫醚 | CAS号1904-62-7 2-二甲氨基甲基苯胺 | CAS号1316652-41-1 N-羟基-3-[1-(苯基硫代... | CAS号21272-85-5 硝甲基苯砜 | CAS号2734-70-5 2,6-二甲氧基苯胺 | CAS号77422-78-7 Benzenamine, 2,... | CAS号77422-82-3 1-amino-N-(phen... | CAS号84304-09-6 Acetic acid,1-(... | CAS号58379-67-2 N-(phenylsulfan...

专利信息

专利号:US-5763681-A
优先权日:1989-09-06
标 题 :Synthesis of stable, water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
发明人：EDWARDS BROOKS; JUO RHOU-RONG
权利人:TROPIX INC
摘要:A novel synthesis of compound having the formula: ##STR1## wherein T is a stabilizing spiro-linked polycycloalkylidene group, R 3 is a C 1 -C 20 alkyl, aralkyl or heteroatom containing group, Y is an aromatic fluorescent chromophore, and Z is a cleavable group which, when cleaved, induces decomposition of the dioxetane ring and emission of optically detectable light, is disclosed. A tertiary phosphorous acid alkyl ester of the formula: n n (R.sup.1 O).sub.3 P n n wherein R 1 is a lower alkyl group, is reacted with an aryl dialkyl acetal produced by reacting a corresponding aryl aldehyde with an alcohol of the formula: n n R.sup.3 OH n n wherein R 3 is as defined above, to produce a 1-alkoxy-1-aryl-methane phosphonate ester of the formula: ##STR2## reacting the phosphonate with base to produce a phosphonate-stabilized carbanion, reacting the carbanion with a ketone of the formula: ##STR3## wherein T is as defined above, to produce an enol ether of the formula: ##STR4## then oxygenating the double bond in the enol ether to give the corresponding 1,2-dioxetane compound.

专利号:WO-2011090968-A1
优先权日:2010-01-22
标题:Post-synthetic chemical modification of rna at the 2'-position of the ribose ring via 'click' chemistry
发明人：ZEWGE DANIEL; GOSSELIN FRANCIS
权利人:MERCK SHARP & DOHME; ZEWGE DANIEL; GOSSELIN FRANCIS
摘要:This invention relates to the post-synthetic chemical modification of RNA at the 2'-position on the ribose ring via a copper catalyzed Huisgen cycloaddition ('click' chemistry: Kolb, Sharpless Drug Discovery Today 2003, 8, 1128). The invention 1) avoids complex, tedious multi-step syntheses of each desired modified ribonucleoside; 2) allows diverse chemical modifications using high-fidelity chemistry that is completely orthogonal to commonly used alkylamino, carboxylate and disulfide linker reactivities; 3) allows introduction of functional groups that are incompatible with modern automated solid-phase synthesis of RNA and subsequent cleavage-deprotection steps; 4) allows introduction of functional groups useful as targeting ligands; and 5) enables high-throughput structure-activity relationship studies on chemically modified RNA in 96-well format.

专利号:US-9505799-B2
优先权日:2011-05-13
标题:18F-labeled precursor of PET radioactive medical supplies, and preparation method thereof
发明人：CHI DAE-YOON; LEE BYOUNG-SE; PARK CHANSOO; LEE MIN-HYUNG; CHA HYOJIN; CHO WOOJIN; KANG HEEWON; KIM KYUNGHUN
权利人:CHI DAE-YOON; LEE BYOUNG-SE; PARK CHANSOO; LEE MIN-HYUNG; CHA HYOJIN; CHO WOOJIN; KANG HEEWON; KIM KYUNGHUN; FUTURECHEM CO LTD
摘要:The present invention relates to a precursor of positron emission tomography (PET) radioactive medical supplies, a preparation method thereof, and an application thereof, and more specifically, to a precursor having a tetravalent organic salt leaving group, a preparation method, and a method for preparing desired PET radioactive medical supplies in a high radiochemical yield within a short preparation time by introducing 18 F using the same through a single step. The precursor having a tetravalent organic salt leaving group of the present invention can simplify the known complex multistep preparation of radioactive medical supplies into a single step, can save production costs because an excessive amount of a phase transfer catalyst is not required, facilitates separation of a compound after reaction, and enables rapid reaction velocity. The features are appropriate for the mass production of PET radioactive medical supplies by an automated synthesis system.

专利号:US-10745740-B2
优先权日:2008-03-19
标题:Sample preparation
发明人：GORDON STEVEN; VEATCH PHILLIP A
权利人:QIAGEN SCIENCES LLC
摘要:The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.

专利号:US-9909174-B2
优先权日:2008-03-19
标 题 :Methods and compositions for incorporating nucleotides
发明人：GORDON STEVEN; OLEJNIK JERZY
权利人:INTELLIGENT BIO SYSTEMS INC
摘要:The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.

专利号:US-9322050-B2
优先权日:2009-04-23
标题 :Hydroxymethyl linkers for labeling nucleotides
发明人：OLEJNIK JERZY
权利人:INTELLIGENT BIOSYSTEMS INC; INTELLIGENT BIO SYSTEMS INC
摘要:The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.