CAS: 6899-10-1; N,N,N-Trimethylhexadecan-1-Aminium

📜在 Sodium Tetraborate Decahydrate,1-苯甲基-1,4-二氢烟酰胺,氧气,亚甲兰,Sodium Hydroxide体系中,用 乙醇,水 作为反应溶剂,化学反应生成 十六烷基三甲基铵,β-环糊精
参考文献:离子表面活性剂和环糊精对1-苄基-1,4-二氢烟酰胺与亚甲蓝氢化物转移反应的影响
标题:离子表面活性剂和环糊精对1-苄基-1,4-二氢烟酰胺与亚甲蓝氢化物转移反应的影响
摘要:在含有环糊精(β-和 γ-Cd)和表面活性剂(十二烷基硫酸钠 (Sds) 的培养基中研究了亚甲蓝 (Mb +) 和 1-苄基-1,4-二氢烟酰胺 (Bnah) 之间的氢化物转移反应的动力学)),十二烷基三甲基溴化铵,十四烷基三甲基溴化铵和十六烷基三甲基溴化铵).阳离子表面活性剂降低了高于 Cmc 的表观一级速率常数 (K Obsd),而 Sds 增加了刚好高于 Cmc 的 K Obsd,然后随着表面活性剂浓度的增加而降低 K Obsd.由于反应物被胶束分离,阳离子表面活性剂的这种行为是典型的胶束效应.bnah 与胶束相关,而 Mb + 离子被胶束的阳离子界面排斥.bnah 和 Mb + 与相同 Sds 胶束的结合增强了反应,但是随着 [sds] 的增加,胶束界面内的试剂稀释导致 K Obsd 降低.在 β-Cd-阳离子表面活性剂混合物中,根据模型解释结果,该模型考虑了 Cd-Bnah,Cd-Mb
DOI:10.1246/bcsj.80.1383

专利信息

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:US-2025214849-A1
优先权日:2023-12-28
标 题:Synthesis of porous crystalline materials in the presence of water-soluble oxidized disulfide oil and fluoride mineralizer
发明人：HODGKINS ROBERT PETER; KOSEOGLU OMER REFA
权利人:SAUDI ARABIAN OIL CO
摘要:Methods are provided for hydrothermal synthesis of porous crystalline materials. The method generally comprises forming a solution of precursors and reagents in effective ratios for a porous crystalline material including a fluoride-containing mineralizer, and water-soluble oxidized disulfide oil. The solution is hydrothermally treated under effective conditions and for an effective time to synthesize porous crystalline materials.

专利号:US-2025214851-A1
优先权日:2023-12-28
标 题 :SYNTHESIS OF POROUS CRYSTALLINE MATERIALS IN THE PRESENCE OF FLUORIDE MINERALIZER AND pH-MODIFIED WATER-SOLUBLE OXIDIZED DISULFIDE OIL
发明人：HODGKINS ROBERT PETER; KOSEOGLU OMER REFA
权利人:SAUDI ARABIAN OIL CO
摘要:Methods are provided for hydrothermal synthesis of porous crystalline materials. The method generally comprises forming a solution of precursors and reagents in effective ratios for a porous crystalline material including a fluoride-containing mineralizer, and a pH-modified water-soluble oxidized disulfide oil composition. The solution is hydrothermally treated under effective conditions and for an effective time to synthesize porous crystalline materials.

专利号:WO-2025109557-A1
优先权日:2023-11-24
标题:Process for the synthesis of monoesters of ethylenediaminetetraacetic acid
发明人：TERAZONO YUICHI
权利人:NUTRIEN AG SOLUTIONS CANADA INC
摘要:A process for the synthesis of a compound of Formula (I) is provided. (I) wherein R is selected from the group consisting of alkyl, alkenyl, alkynyl, and steroidyl. The process comprises reacting a compound of Formula (IIa), Formula (IIb) or a mixture thereof with a compound of Formula R-X, to obtain a compound of Formula (IIIa), a compound of Formula (IIIb) or a mixture thereof, wherein A+ is a cesium cation, a quaternary ammonium cation or a quaternary phosphonium cation, and X is a leaving group; and reacting the compound of Formula (IIIa), compound of Formula (IIIb) or mixture thereof with an acid to obtain a reaction product which comprises the compound of Formula (I). (IIa) (IIb) (IIIa) (IIIb)

专利号:US-2025214848-A1
优先权日:2023-12-28
标 题:Synthesis of b-oriented mfi in the presence of water-soluble oxidized disulfide oil and fluoride mineralizer
发明人：HODGKINS ROBERT PETER; KOSEOGLU OMER REFA
权利人:SAUDI ARABIAN OIL CO
摘要:Methods are provided for hydrothermal synthesis of b-oriented MFI zeolite. The method generally comprises forming a solution of precursors and reagents in effective ratios for a b-oriented MFI zeolite including a fluoride-containing mineralizer, and water-soluble oxidized disulfide oil. The solution is hydrothermally treated under effective conditions and for an effective time to synthesize b-oriented MFI zeolite.

专利号:US-2004006137-A1
优先权日:2002-06-28
标题:Asymmetric synthesis of amino-pyrrolidinones and a crystalline, free-base amino-pyrrolidinone
发明人：WALTERMIRE ROBERT E; CAMPAGNA SILVIO; SAVAGE SCOTT A; BORDAWEKAR SHAILENDRA; MADUSKUIE THOMAS P; DESIKAN SRIDHAR; ANDERSON STEPHEN R
摘要:A novel process for the asymmetric synthesis of an amino-pyrrolidinone of the type shown below is described. n n n These compounds are useful as intermediates for MMP and TACE inhibitors. n Crystalline, free-base form of Compound J ((2R)-2-((3R)-3-amino-3-{-[(2-methyl-4-quinolinyl)methoxy]phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide): n n n which is useful as a TACE inhibitor, pharmaceutical compositions comprising the same, and methods of using the same for treating inflammatory diseases are also described.