CAS: 62031-54-3; (R)-2-(2-((R)-2-((R)-1-(D-Phenylalanyl-D-Asparaginyl-D-Leucyl)Pyrrolidine-2-Carboxamido)-4-Methylpentanamido)Acetamido)-N1-((R)-1-(((R)-6-Amino-1-(((R)-6-Amino-1-((R)-2-(Hydroxymethyl)Pyrrolidin-1-yl)-1-Oxohexan-2-yl)Amino)-1-Oxohexan-2-yl)Amino)-3-(4-Hydroxyphenyl)-1-Oxopropan-2-yl)Succinamide
该化合物是一种蛋白质,在各种生物过程,包括细胞生长,组织修复和血管生长中发挥着关键作用;FGF是一个与细胞表面特定受体相互作用的肝素有约束力增长因素的大家庭,启动了促进细胞扩散和差异的信号路径;FGF涉及胚胎发育和伤口愈合,影响血管的形成和组织再生;其特点是能够与肝素结合,从而增强它的稳定性和活动;FFGF通常是针对伤害或压力生产的,而且其活动在身体内受到严格管制;在治疗方面,FGF由于能够刺激细胞生长和修复受损的组织,因此在再生医学和组织工程方面的潜力得到了探讨;但是,必须谨慎地控制其使用,以避免细胞过度扩散,从而可能导致肿瘤的形成.
- ⚠️《2026年兴奋剂目录》
- 英文名称(R)-2-(2-((R)-2-((R)-1-(D-Phenylalanyl-D-Asparaginyl-D-Leucyl)Pyrrolidine-2-Carboxamido)-4-Methylpentanamido)Acetamido)-N1-((R)-1-(((R)-6-Amino-1-(((R)-6-Amino-1-((R)-2-(Hydroxymethyl)Pyrrolidin-1-yl)-1-Oxohexan-2-yl)Amino)-1-Oxohexan-2-yl)Amino)-3-(4-Hydroxyphenyl)-1-Oxopropan-2-yl)Succinamide
- 中文名称碱性成纤维细胞生长因子
- IUPAC名称(R)-2-(2-((R)-2-((R)-1-(D-phenylalanyl-D-asparaginyl-D-leucyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)acetamido)-N1-((R)-1-(((R)-6-amino-1-(((R)-6-amino-1-((R)-2-(hydroxymethyl)pyrrolidin-1-yl)-1-oxohexan-2-yl)amino)-1-oxohexan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)succinamide
- 其它别名Recombinant Human Basic Fibroblast Growth Factor(Bfgf); Fibroblast Growth Factor(Basic) (Bfgf / Fgfb), Human, Recombinant; Recombinant Human Basic Fibroblast Growth Factor,Rhbfgf; Fibroblast Growth Factor, Acidic*fragmen T 1-11 From; Fibroblast Growth Factor Bovine, Tissue Culture Gra; Fibroblast Growth Factor, Basic*fragment 1-24 Bovin; Fibroblast Growth Factor From Bovine Pituitary; Basic Fibroblast Growth Factor (Fgf 2) Human
- CAS编号62031-54-3
- 分子式:C62H97N15O14分子量:1276.55
- 产品CID: 1602548
- 产品分类生物化工 → 多肽
物理性质
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
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📌 第三方产品分析报告
合成参考文献
参考文献:10.1128/mcb.01436-09
摘要:Csiszar A, Vogelsang E, Beug H, Leptin M. A Novel Conserved Phosphotyrosine Motif in the Drosophila Fibroblast Growth Factor Signaling Adaptor Dof with a Redundant Role in Signal Transmission. Molecular and Cellular Biology. 2010 Apr 01;30(8):2017–27. doi: 10.1128/mcb.01436-09.
参考文献:10.1210/jc.2009-1671
摘要:Imel EA, DiMeglio LA, Hui SL, Carpenter TO, Econs MJ. Treatment of X-linked hypophosphatemia with calcitriol and phosphate increases circulating fibroblast growth factor 23 concentrations. J Clin Endocrinol Metab. 2010 Apr;95(4):1846–50.
参考文献:10.1210/jc.2009-1576
摘要:Bacchetta J, Dubourg L, Harambat J, Ranchin B, Abou-Jaoude P, Arnaud S, Carlier MC, Richard M, Cochat P. The influence of glomerular filtration rate and age on fibroblast growth factor 23 serum levels in pediatric chronic kidney disease. J Clin Endocrinol Metab. 2010 Apr;95(4):1741–8. doi: 10.1210/jc.2009-1576.
参考文献:10.18632/aging.100108
摘要:Wu X, Li Y. Role of FGF19 induced FGFR4 activation in the regulation of glucose homeostasis. Aging (Albany NY). 2009 Dec 09;1(12):1023–7.
参考文献:10.1172/jci41514
摘要:Wang H, Venkatesh M, Li H, Goetz R, Mukherjee S, Biswas A, Zhu L, Kaubisch A, Wang L, Pullman J, Whitney K, Kuro-o M, Roig AI, Shay JW, Mohammadi M, Mani S. Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. J Clin Invest. 2011 Aug;121(8):3220–32.
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