专利号:US-2023174477-A1 优先权日:2021-12-03 标题:Methods for synthesis of the tricyclic prostaglandin d2 metabolite methyl ester 发明人:DAI MINGJI; SIMS HUNTER 权利人:PURDUE RESEARCH FOUNDATION 摘要:Methods for the synthesis of a tricyclic-prostaglandin D 2 metabolite methyl ester or a pharmaceutically acceptable salt thereof.
专利号:US-10604479-B2 优先权日:2013-11-18 标 题:Continuous process for the one-pot synthesis of metal salts and metal complexes 发明人:LEONARDI GIULIANO; GASPERONI GIOVANNI 权利人:VOLARE & CONNECTING LLC; LEONARDI GIULIANO; NOVUS INT INC 摘要:A continuous process is described for the one-pot synthesis of compounds, such as metal salts and metal complexes, as well as optionally for the protection of the compounds thus obtained by coating and/or impregnation with suitable compounds.
专利号:US-9597327-B2 优先权日:2005-05-25 标 题:Synthesis of (R)-N-methylnaltrexone 发明人:DOSHAN HAROLD D; PEREZ JULIO 权利人:PROGENICS PHARM INC 摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
专利号:US-7473541-B2 优先权日:2004-07-09 标 题:Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities 发明人:GROSS RICHARD W; JENKINS CHRISTOPHER 权利人:GROSS RICHARD W; JENKINS CHRISTOPHER 摘要:Isolated novel and purified and characterized phospholipase A 2 , referred to herein as calcium-independent phospholipase A 2 zeta (iPLA 2 zeta) having SEQ. ID. NO: 2 (See FIG. 1 ), and nucleic acid sequence (SEQ. ID. NO: 4), and calcium-independent phospholipase A 2 eta (iPLA 2 eta) having SEQ. ID. NO: 3 (See FIG. 1 ), and nucleic acid sequences (SEQ. ID. NO: 5). For the first time herein, these novel enzymes have been isolated and characterized and are involved in the catalysis, synthesis and hydrolysis of lipids in a living mammalian cell. Moreover, these enzymes iPLA 2 zeta and iPLA 2 eta through the process of transesterification can catalyze the net anabolic synthesis of triglycerides through a variety of metabolic precursors (e.g. monoacylglycerol, diacylglycerol and acyl CoA).
专利号:US-2025305010-A1 优先权日:2022-05-08 标题:Lipid compositions and methods of producing same 发明人:KEREN TOMER; ELLA EZRA; ARGOV-ARGAMAN NURIT 权利人:WILK TECH INTERNATIONAL LTD; YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD 摘要:Provided is a method of increasing lipid synthesis or accumulation in mammary epithelial cells (MECs) culture and optionally secretion therefrom. The method comprising contacting the MECs with an LXR agonist in the presence of a fatty acid to thereby increase lipid synthesis or accumulation and optionally secretion of lipids. Also provided is a method of producing synthetic fat globules, the method comprising: (a) isolating lipid droplets from cells in culture; (b) encapsulating the droplets with a lipid bilayer, thereby producing synthetic fat globules. Also provided are compositions produced thereby.
专利号:US-2023065361-A1 优先权日:2021-08-18 标 题:Method for increasing use efficiency of lipase during enzymatic reaction 发明人:WANG XIAOSAN; HUANG YE; Huang Zhuoneng; CHEN YE; LIU KEYING; HUANG YAQI; WANG XIAOHAN; CHANG MING 权利人:UNIV JIANGNAN 摘要:The present disclosure discloses a method for increasing the usage efficiency of a lipase in the enzymatic reaction, belonging to the technical field of food processing. In the present disclosure, the peroxide value of raw materials required for enzymatic synthesis of a structured lipid is reduced by a distillation method or an adsorption method, and then the raw material and a lipase undergo catalytic reaction to synthesize the structured lipid, so as to maintain the activity of the lipase and increase the reuse rate of the enzyme. The distillation method includes deodorization and molecular distillation. The present disclosure provides a method for manufacturing a structured lipid by a high efficiency and low-cost enzymatic synthesis, addressing to the issues such as large enzyme consumption, expansive cost, low enzyme utilization rate in the traditional industrial production. Therefore, the method provided by the present disclosure has certain development potential and practical significance.