CAS: 50892-23-4; 2-((4-Chloro-6-((2,3-Dimethylphenyl)Amino)Pyrimidin-2-yl)Thio)Acetic Acid

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CAS号87-59-2 2,3-二甲基苯胺 | CAS号50892-12-1 ethyl 2-(4,6-di... | CAS号50892-49-4 AKOS BC-1524 | CAS号65089-17-0 匹立昔尔 | CAS号86627-11-4 2-[4-(2,3-dimet...

📜3-(二甲基氨基)-2-(2-噻吩羰基)-丙烯腈置于sodium Hydroxide,N,N-二乙基苯胺,三氯氧磷体系中,用 乙醇 作为反应溶剂,化学反应 17.03H,反应生成 匹立尼酸
参考文献:Novel Pyrimidine And 1,3,5-Triazine Hypolipemic Agents
标题:Novel Pyrimidine And 1,3,5-Triazine Hypolipemic Agents
摘要:New Compounds Were Synthesized By Changing The Substituents Of A Trisubstituted Pyrimidine,I.E.,[[4-Chloro-6-[(2,3-Dimethylphenyl)Amino]-2-Pyrimidinyl]Thio] Acetic Acid,A Potent Hypolipidemic Agent,Impaired,However,By A Marked Hepatomegaly-Inducing Effect. The Structural Variations Led To The Subsidence (14B,I.E.,4-Chloro-2-(Dimethylamino)-6-[(2,3-Dimethylphenyl)Amino]Pyrimidine) Or To The Reduction (18B,[[4-Chloro-6-[(2,3-Dimethylphenyl)Amino]-2-Pyrimidinyl]Amino] Acetic Acid) Of Said Untoward Effect But Still Maintained The Hypolipidemic Effect That,Although Markedly Decreased,Still Proves Significant For Serum Cholesterol And Triglycerides (18B) Or For Serum Triglycerides Only (14B).
DOI:10.1021/jm00378A016

专利信息

专利号:WO-2009117985-A1
优先权日:2008-06-12
标题 :Pirinixic acid derivatives as prostglandin e2 synthesis inhibitors for treating inflammatory diseases
发明人：WERZ OLIVER; KOEBERLE ANDREAS; SCHUBERT-ZSILAVECZ MANFRED; POPESCU LAURA; SYHA YVONNE
权利人:MEDEON PHARMACEUTICALS GMBH; UNIV TUEBINGEN; WERZ OLIVER; KOEBERLE ANDREAS; SCHUBERT-ZSILAVECZ MANFRED; POPESCU LAURA; SYHA YVONNE
摘要:The invention relates to pirinixic acid derivatives, especially a-substituted pirinixic acids and pirinixic acid esters, and the structural derivatives thereof with the following structural formula. The pirinixic acid derivatives inhibit the PGE2 synthesis, especially that of the mPGES-1. The invention also relates to the use of said pirinixic acid derivatives for producing a medicament for treating prostaglandin E2-mediated diseases, especially inflammatory diseases, painful and feverish conditions, cardiovascular events and cancerous diseases associated with an increased inducible microsomal prostaglandin E2 synthesis-1 (mPGES-1) activity or increased prostaglandin E2 synthesis.

专利号:WO-2022136897-A1
优先权日:2020-12-23
标题 :Cosmetic composition comprising an aqueous or an hydroalcoholic extract of peony
发明人：CHOISY PATRICK; GOURGUILLON LORÈNE; NIZARD CARINE; LEBLANC EMMANUELLE
权利人:LVMH RECH
摘要:The present invention relates to a cosmetic composition comprising aqueous or hydroalcoholic extract of Paeonia suffruticosa Yao Huang, and the use thereof for anti- aging, in particular to promote and/or improve the barrier function, densify the extracellular matrix and/or reduce its degradation, improve the elasticity and/or firmness of the skin, improve the radiance and/or homogeneity of the skin, improve the collagen synthesis in the skin.

专利号:DE-102008015432-A1
优先权日:2008-06-12
标题 :Use of pirinixic acid derivatives to inhibit prostaglandin E2 synthesis

专利号:CN-119818387-A
优先权日:2025-01-07
标题 :Application of a cyclic peptide and its synthesis method