CAS: 43076-61-5; 1-(4-(Tert-Butyl)Phenyl)-4-Chlorobutan-1-One

上下游产品

CAS号63488-10-8 4-叔丁基苯基溴化镁 | CAS号4635-59-0 4-氯丁酰氯 | CAS号50679-08-8 特非那定 | CAS号90729-43-4 依巴斯汀 | CAS号43076-30-8 特非那酮

4-叔丁基溴苯置于manganese(II) Triflate,碘,四丁基醋酸铵,Magnesium,溶剂黄146,Magnesium Chloride体系中,用 四氢呋喃,乙腈 作为反应溶剂,化学反应 3.5H,反应生成 4'-叔丁基-4-氯丁酰苯
参考文献:锰催化的烷氧基自由基对环烷醇的电化学解构氯化反应.
标题:锰催化的烷氧基自由基对环烷醇的电化学解构氯化反应.
摘要:已经开发了锰催化的环烷醇的电化学解构氯化法.这种电化学方法可从醇中获得烷氧基,并具有广泛的底物范围,可将各种环丙醇和环丁醇转化为可合成使用的β-和γ-氯化酮(40个实例).此外,采用循环流电化学和连续在线纯化的组合以克为单位获得产物.
DOI:10.1021/acs.Orglett.9B03652

专利信息

专利号:US-2012302756-A1
优先权日:2010-02-19
标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines
发明人：LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
权利人:LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
摘要:The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.

专利号:WO-2011103263-A2
优先权日:2010-02-19
标题:Process for synthesis of 2-substituted pyrrolidines and piperadines

专利号:EP-2536687-A2
优先权日:2010-02-19
标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines