CAS: 4227-95-6; Iodomethane-13C

上下游产品

CAS号51624-21-6 溴甲烷-(13)C | CAS号1641-69-6 C13取代的一氧化碳 | CAS号74-88-4 碘甲烷 | CAS号14742-26-8 甲醇-13C | CAS号1111-72-4 二氧化碳-13C | CAS号67-56-1 甲醇 | CAS号542-69-8 碘代正丁烷 | CAS号19495-43-3 [(6)Li],[(13)C]... | CAS号207556-12-5 methyl trifluor... | CAS号30860-31-2 碳-13C二硫化 | CAS号3228-27-1 甲醛13C溶液 | CAS号32480-00-5 硝基甲烷-13C | CAS号125562-53-0 甲基-13C苯基砜 | CAS号136321-14-7 methylsulfanylm... | CAS号1563-80-0 乙酸-2-13C | CAS号81826-67-7 甲基-13C-三苯基碘化膦

📜碳十三甲醇置于氢碘酸体系中,用 水 作为反应溶剂,化学反应 6.0H,反应生成 碘甲烷-13C
参考文献:[13C]甲醇一步法大规模制备[13C]甲基苯硫醚
标题:[13C]甲醇一步法大规模制备[13C]甲基苯硫醚
摘要:我们开发了一种大规模的"一锅法"程序,用于将市售的 [13C]-或 [2H3,13C] 甲醇转化为 [13C]-或 [2H3,13C] 甲基苯硫醚.[13C] 甲基苯硫醚是一种潜在的多功能,化学稳定且非挥发性的标记前体.此外,我们报道了一种将 [13C] 甲基苯硫醚氧化为 [13C] 甲基苯砜的有效方法.最后,我们使用 [13C] 甲基苯硫醚来生产 13C 标记的甲基碘,其中正好包含一两个氘核.
DOI:10.1021/op025530P

专利信息

专利号:US-7662993-B2
优先权日:2005-11-04
标 题:Synthesis of [13C] and [2H] substituted methacrylic acid, [13C] and [2H] substituted methyl methacrylate and/or related compounds
发明人：ALVAREZ MARC A; MARTINEZ RODOLFO A; UNKEFER CLIFFORD J
权利人:LOS ALAMOS NAT SECURITY LLC
摘要:The present invention is directed to labeled compounds of the formulae n n n n n n n n n n n n wherein Q is selected from the group consisting of —S(â•?O)—, and —S(â•?O) 2 —, Z is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure n n n n n nwherein R 1 , R 2 , R 3 , R 4 and R 5 are each independently selected from the group consisting of hydrogen, a C 1 -C 4 lower alkyl, a halogen, and an amino group selected from the group consisting of NH 2 , NHR and NRR′ where R and R′ are each independently selected from the group consisting of a C 1 -C 4 lower alkyl, an aryl, and an alkoxy group, and X is selected from the group consisting of hydrogen, a C 1 -C 4 lower alkyl group, and a fully-deuterated C 1 -C 4 lower alkylgroup.

专利号:US-6713044-B2
优先权日:2002-02-13
标题 :Synthesis of [2H1, 13C], [2H2, 13C] and [2H3, 13C]methyl aryl sulfides
发明人：MARTINEZ RODOLFO A; ALVAREZ MARC A; SILKS III LOUIS A; UNKEFER CLIFFORD J
权利人:UNIV CALIFORNIA
摘要:The present invention is directed to labeled compounds, [ 2 H 1 , 13 C], [ 2 H 2 , 13 C] and [ 2 H 3 , 13 C]methyl aryl sulfides wherein the 13 C methyl group attached to the sulfur of the sulfide includes exactly one, two or three deuterium atoms and the aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure n wherein R 1 , R 2 , R 3 , R 4 , and R 5 are each independently, hydrogen, a C 1 -C 4 lower alkyl, a halogen, an amino group from the group consisting of NH 2 , NHR and NRR′ where R and R′ are each a C 1 -C 4 lower alkyl, a phenyl, or an alkoxy group. The present invention is also directed to processes of preparing [ 2 H 1 , 13 C], [ 2 H 2 , 13 C] and [ 2 H 3 , 13 C]methyl aryl sulfides wherein the 13 C methyl group attached to the sulfur of the sulfide includes exactly one, two or three deuterium atoms. The present invention is also directed to the labeled compounds of [ 2 H 1 , 13 C]methyl iodide and [ 2 H 2 , 13 C]methyl iodide.

专利号:US-6764673-B2
优先权日:2002-02-13
标题 :Synthesis of [2H1, 13C], [2H2, 13C] and [2H3, 13C]methyl aryl sulfones and sulfoxides
发明人：MARTINEZ RODOLFO A; ALVAREZ MARC A; SILKS III LOUIS A; UNKEFER CLIFFORD J; SCHMIDT JURGEN G
权利人:UNIV CALIFORNIA
摘要:The present invention is directed to labeled compounds, [ 2 H 1 , 13 C], [ 2 H 2 , 13 C] and [ 2 H 3 , 13 C]methyl aryl sulfones and [ 2 H 1 , 13 C], [ 2 H 2 , 13 C] and [ 2 H 3 , 13 C]methyl aryl sulfoxides, wherein the 13 C methyl group attached to the sulfur of the sulfone or sulfoxide includes exactly one, two or three deuterium atoms and the aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure: n wherein R 1 , R 2 , R 3 , R 4 and R 5 are each independently, hydrogen, a C 1 -C 4 lower alkyl, a halogen, an amino group from the group consisting of NH 2 , NHR and NRR′ where R and R′ are each a C 1 -C 4 lower alkyl, a phenyl, or an alkoxy group. The present invention is also directed to processes of preparing methyl aryl sulfones and methyl aryl sulfoxides.

专利号:US-2003158445-A1
优先权日:2002-02-13
标题:Synthesis of [2H1, 13C], [2H2, 13C] and [2H3, 13C]methyl aryl sulfones and sulfoxides

专利号:US-2003153789-A1
优先权日:2002-02-13
标题 :Synthesis of [2H1, 13C], [2H2, 13C] and [2H3, 13C]methyl aryl sulfides

专利号:US-8551996-B2
优先权日:2009-02-20
标题 :Compounds, compositions, methods of synthesis, and methods of treatment
发明人：STEHOUWER JEFF; GOODMAN MARK; KILTS CLINT; NEMEROFF CHARLES
权利人:STEHOUWER JEFF; GOODMAN MARK; KILTS CLINT; NEMEROFF CHARLES; UNIV EMORY
摘要:Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein, methods of imaging, method of forming a compound as described herein, and the like. In particular, embodiments of the disclosure include a series of triamino-pyridine derivatives and labeled triamino-pyridine derivatives, methods of synthesizing these compounds, intermediate compounds, methods of treatment using these compounds, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a condition (e.g., corticotropin releasing factor type-1 (CRF1)) and/or related biological events, using triamino-pyridine derivatives, and the like. In addition, the present disclosure includes compositions (e.g., labeled triamino-pyridine derivatives that are ligands for the CRF1 receptor) used in and methods relating to non-invasive imaging (e.g., positron emission tomography (PET) imaging or SPECT imaging).