CAS: 3923-52-2; 1,1-Diphenylprop-2-Yn-1-Ol

上下游产品

ethynyldimagnesium dibromide benzophenone diethyl ether sodium acetylide 2-(1,1-diphenyl-prop-2-ynyloxy)-tetrahydro-pyran acetic acid 2-oxo-1,1-diphenyl-propyl ester 1,1-diphenyl-2-propyn-1-yl acetate 1,1,6,6-tetraphenyl-1,2,3,4,5-hexapentaene

O-(Trimethylsilyl)-1,1-Diphenyl-2-Propyn-1-Ol置于potassium Carbonate体系中,用 甲醇 用作溶剂,化学反应 2.0H,反应生成1,1-二苯基-2-丙炔-1-醇
参考文献:Brønsted Acid Mediated Nitrogenation Of Propargylic Alcohols: An Efficient Approach To Alkenyl Nitriles
标题:Brønsted Acid Mediated Nitrogenation Of Propargylic Alcohols: An Efficient Approach To Alkenyl Nitriles
摘要:开发了一种由易于获得的炔丙基醇制备烯基腈的新颖且高效的方法.这种氮化反应无需过渡金属参与,在常温常压下即可进行,因而该方案具有潜在的应用前景和实用性.此外,Nh4Br作为一种高效添加剂,能提高反应的立体选择性.
Doi:10.1039/c4Ob00888J

专利信息

专利号:US-11779912-B2
优先权日:2016-10-19
标题 :Synthesis and characterization of Ru alkylidene complexes
发明人：JOHNS ADAM M; HERRON JESSICA R; PEDERSON RICHARD L; FIAMENGO BRYAN A; BEERMAN JENNIFER A; LIN TZU-PIN; CHU CRYSTAL K; GRUBBS ROBERT H
权利人:UMICORE AG & CO KG; CALIFORNIA INST OF TECHN
摘要:This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, articles of manufacture comprising such compounds, and the use of such compounds in the metathesis of olefins and olefin compounds. The invention has utility in the fields of catalysts, organic synthesis, polymer chemistry, and industrial and fine chemicals industry.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-8372986-B2
优先权日:2005-09-30
标 题 :Ruthenium-catalyzed cycloaddition of alkynes and organic azides
发明人：FOKIN VALERY; JIA GUOCHENG; SHARPLESS K BARRY
权利人:SCRIPPS RESEARCH INST; UNIV HONG KONG SCIENCE & TECHN; FOKIN VALERY; JIA GUOCHENG; SHARPLESS K BARRY
摘要:A convenient process for the regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles and 1,4,5-trisubstituted 1,2,3-triazoles from organic azides and alkynes employs catalytic ruthenium.

专利号:US-8703985-B2
优先权日:2008-10-04
标 题:Method for preparation of ruthenium-indenylidene carbene catalysts
发明人：WINDE ROLAND; KARCH RALF; RIVAS-NASS ANDREAS; DOPPIU ANGELINO; PETER GERHARD; WOERNER EILEEN
权利人:WINDE ROLAND; KARCH RALF; RIVAS-NASS ANDREAS; DOPPIU ANGELINO; PETER GERHARD; WOERNER EILEEN; UMICORE AG & CO KG
摘要:The present invention is directed to a method for the preparation of ruthenium indenylidene carbene catalysts of the type (L)(L′)X 2 Ru(II)(aryl-indenylidene). The method comprises the steps of reacting the precursor compound Ru(PPh 3 ) n X 2 (n=3-4) with a propargyl alcohol derivative in an cyclic diether solvent such as 1,4-dioxane at temperatures in the range of 80 to 130° C. and reaction times of 1 to 60 minutes. Optionally, additional neutral electron donor ligands such as PCy 3 , phobane ligands or NHC ligands are added to the reaction mixture for ligand exchange. The method includes a precipitation step for purification, after which the product is isolated. The ruthenium-indenylidene carbene catalysts are obtained in high purity and are used as catalysts for metathesis reactions (RCM, ROMP and CM) and as precursors for the synthesis of modified ruthenium carbene catalysts.

专利号:US-6774229-B2
优先权日:1999-11-21
标 题 :Coupling condensation synthesis of heterocycles
发明人：MUELLER THOMAS; ANSORGE MARKUS
权利人:MORPHOCHEM AG
摘要:The invention relates to a process for the preparation of heterocycles, characterised in that the following components: n i) a propargyl derivative of the general structural formula I n  a wherein Het is an optionally substituted hetero atom and A is a substituted or unsubstituted aromatic entity, a substituted or unsubstituted aromatic heterocycle, a substituted or unsubstituted vinyl arene and/or a derivative thereof, an olefin, an alkyne, an acceptor group or a nitrile; n (ii) a compound of the general structural formula II, n n n B—X  II, n n n  wherein B is an electron-deficient substituted or unsubstituted aromatic entity with or without an acceptor group, an electron-deficient substituted or unsubstituted heteroaromatic entity with or without an acceptor group, an electron-deficient olefin and/or alkyne, a metal complex, and X is a leaving group; n (iii) a nucleophile of the general structural formula III, n n n Y—C n —Z  III, n n n  wherein Y and/or Z, each independently of the other, is an amino group, thio group (mercapto group), seleno group, telluro group, hydroxy group (alcohol group), imido group, carbonyl group, thiocarbonyl group, selenocarbonyl group, tellurocarbonyl group; C is a substituted or unsubstituted C atom, a substituted or unsubstituted or annelated CC double bond or single bond and n=0-10, preferably 1-5, preferably are reacted in a one-pot reaction by cyclocondensation to form 4- to 10-membered, preferably 5- to 7-membered, heterocyclic, aromatic or non-aromatic ring systems.

专利号:US-7348290-B2
优先权日:2002-03-11
标题 :Arene-ruthenium complexes immobilized on polymers, catalysts consisting of the complexes, and processes for organic syntheses with the same
发明人：KOBAYASHI SHU
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:A novel polymer-supported arene-ruthenium complex represented by the following formula: n n, wherein A represents an organic polymer with a side chain containing an aromatic ring coordinated to Ru, X 1 and X 2 represent the same or different halogen atoms, and R represents a hydrocarbon group that may have a substituent is provided for use as a catalyst. This novel polymer-supported arene-ruthenium complex and catalyst thereof can be produced by a simple process, are stable and easy to recover, have a high catalytic activity, and can be used for various organic synthesis reactions. Novel methods for an organic synthesis reaction such as ring-opening metathesis reaction of an olefin compound and reduction of a carbonyl group, using the catalyst are provided.