CAS: 392-85-8; 2-Fluorobenzotrifluoride

上下游产品

CAS号88-17-5 2-氨基三氟甲苯 | CAS号98-08-8 三氟甲苯 | CAS号1316231-59-0 2-(trifluoromet... | CAS号462-06-6 氟苯 | CAS号55642-42-7 trifluoro(trifl... | CAS号63854-31-9 1-(2-三氟甲苯基)哌嗪 | CAS号115029-22-6 2-氟-3-(三氟甲基)苯甲酸 | CAS号112641-20-0 2-氟-3-(三氟甲基)苯甲醛 | CAS号1211596-75-6 2-氰基-3-(三氟甲基)苯甲酸甲酯

2-硝基-Alpha,Alpha,Alpha-三氟甲苯置于四丁基氟化铵体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 2.5H,以95.1%的收率获得2-氟三氟甲苯
参考文献:一种邻三氟甲基苯甲酰胺的制备方法
标题:一种邻三氟甲基苯甲酰胺的制备方法
摘要:本发明公开了一种邻三氟甲基苯甲酰胺的制备方法.该制备方法包括如下步骤:(1)在有机溶剂中,将邻硝基三氟甲苯和氟化盐进行如下所示的脱硝氟代反应,得到邻氟三氟甲苯;(2)在有机溶剂中,将邻氟三氟甲苯和氰基化试剂进行如下所示的脱氟氰代反应,得到邻三氟甲基苯腈;(3)在碱存在下,将邻三氟甲基苯腈,过氧化氢进行如下所示的水解反应.该制备方法后处理简单,产物纯度高,杂质少,收率高.

专利信息

专利号:US-2013184465-A1
优先权日:2010-09-30
标 题:Process for the synthesis of thio-triazolo-group containing compounds
发明人：DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL
权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE
摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.

专利号:US-2023399302-A1
优先权日:2020-10-29
标题:Process for the preparation of heteroaryl-substituted sulfur(vi) compounds
发明人：LOPCHUK JUSTIN M; SHULTZ ZACHARY P; SCATTOLIN THOMAS
权利人:H LEE MOFFITT CANCER CT & RES
摘要:The present disclosure provides processes for the synthesis of organic compounds, in particular processes for the synthesis of heteroaryl-substituted sulfur(VI) compounds by nucleophilic aromatic substitution.

专利号:US-2023295162-A1
优先权日:2020-08-06
标 题 :Synthesis of novel imipridone derivatives and their evaluation for their anticancer activity
发明人：CSÃ?MPAI ANTAL; BÃ?RÃ?NY PÉTER; CZUCZI TAMÃ?S; Kovács Imre; ADAMIS BÃ?LINT; NÉMETH ZSÓFIA; MURÃ?NYI JÓZSEF; OLÃ?HNÉ SZABÓ RITA; BOSZE SZILVIA; MEZO GÃ?BOR; KOHIDAI LÃ?SZLÓ; LAJKÓ ESZTER; TAKÃ?CS ANGÉLA; Láng Orsolya; MEZO DIÃ?NA
权利人:EOETVOES LORAND TUDOMANYEGYETEM; SEMMELWEIS EGYETEM
摘要:The present invention relates to compounds of formula (I) (I) or pharmaceutically acceptable salts, and stereoisomers thereof, including enantiomers, racemic mixtures, mixtures of enantiomers, or combinations thereof, which are applicable for use in treating cancer diseases. The present invention further relates to a pharmaceutical composition comprising the above compounds.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:WO-9967219-A1
优先权日:1998-06-22
标 题:Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
发明人：AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
摘要:Compounds of formula (I), wherein W is a cyclic group of the type (2); (3); Y is represented by the formula (II); these compounds inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6774125-B2
优先权日:1998-06-22
标 题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.