📜1,4-甲苯磺酰基-2,3-异亚丙基苏糖醇,Sodium Diphenylphosphide 以8%的收率获得 参考文献:Green,Malcolm L. H.;Walker,Neil M.,J. Organomet. Chem.,344,(1988) N 3,379-382 标题:Green,Malcolm L. H.;Walker,Neil M.,J. Organomet. Chem.,344,(1988) N 3,379-382
专利号:US-8410320-B2 优先权日:2010-12-07 标 题 :Method for synthesis of secondary alcohols 发明人:CHENG CHIEN-HONG; KARTHIKEYAN JAGANATHAN; HUANG PANG-CHI 权利人:CHENG CHIEN-HONG; KARTHIKEYAN JAGANATHAN; HUANG PANG-CHI; NAT UNIV TSING HUA 摘要:A method for synthesis of secondary alcohols is provided for pharmaceutical secondary alcohol by addition of organoboronic acids with aldehydes in presence of the cobalt ion and bidentate ligands as the catalyst. In addition, an enantioselective synthesis method for secondary alcohols is also herein provided in the present invention. The present invention has advantages in using less expensive cobalt ion and commercially available chiral ligands as the catalyst, wide scope of organoboronic acids and aldehydes compatible with this catalytic reaction and achieving excellent yields and/or enantiomeric excess.
专利号:WO-2024201469-A1 优先权日:2023-03-29 标 题:Process for the preparation of amine intermediates 发明人:YACOVAN AVIHAI; BAR NAHUM ITSIK; KRAKOVICH VLADA; PARNES REGEV; WANG HONGFA; ZHANG QINGLONG; Zi Weiwei 权利人:ADAMA AGAN LTD 摘要:The present disclosure relates a process for the preparation of amines as intermediates for the synthesis of triazines, which are suitable for use as herbicides for controlling weeds.
专利号:US-4204997-A 优先权日:1979-03-19 标题 :Asymmetric amination of 1,3-dienes 发明人:HOBBS CHARLES F; MCMACKINS DUDLEY E 权利人:MONSANTO CO 摘要:A process for the asymmetric synthesis of amines which comprises the amination of a conjugated diene having from 4 to about 20 carbon atoms in the presence of a catalyst system comprising a palladium compound and an optically active phosphine ligand containing at least two phosphorus atoms.
专利号:US-8193392-B2 优先权日:2005-07-29 标 题:Method for enantioselective synthesis of phosphorus-stereogenic phosphines 发明人:SCRIBAN CORINA; GLUECK DAVID S 权利人:SCRIBAN CORINA; GLUECK DAVID S; DARTMOUTH COLLEGE 摘要:The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.
专利号:US-10851059-B2 优先权日:2016-08-17 标题:Processes and intermediates for NEP inhibitor synthesis 发明人:KLEINBECK-RINIKER FLORIAN KARL; MAFLI IVES; MARTIN BENJAMIN; PENN GERHARD; SEDELMEIER GOTTFRIED; SEDELMEIER JOERG; VENTURONI FRANCESCO 权利人:NOVARTIS AG 摘要:The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.
专利号:US-6399787-B1 优先权日:1997-06-13 标 题:Catalytic asymmetric hydrogenation, hydroformylation, and hydrovinylation via transition metal catalysts with phosphines and phosphites 发明人:ZHANG XUMU 权利人:PENN STATE RES FOUND 摘要:Novel transition metal catalysts with conformationally rigid chiral phosphines and phosphites are developed for asymmetric carbon-hydrogen and carbon-carbon bond formation. The invention emphasizes synthesis of chiral amines, beta-amino acids and related compounds via catalytic asymmetric hydrogenation based on chiral monodentate and bidentate phosphines with cyclic ring structures. The ligands contain rigid ring structures.