CAS: 37002-48-5; (((4S,5S)-2,2-Dimethyl-1,3-Dioxolane-4,5-Diyl)Bis(Methylene))Bis(Diphenylphosphine)

该化合物是一种复杂的有机磷化合物,其独特的结构特征包括二氧环和二苯基磷酸盐组,该化合物一般会由于存在大宗二苯酚亚组而表现出高度的不耐烦障碍,这可能会影响其反应和协调性能.二氧烷混合物有助于其有机溶剂的稳定性和溶性.作为金属中心的一个固定体,它可以协调金属中心,使其在各种催化应用中,特别是在有机金属化学中发挥作用.二氧烷环的立体化学学会传播出气,这在不对称合成合成中可能很重要.此外,该化合物的磷类组可以参与红毒反应,进一步扩大其在合成化学中的用途.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

sodium diphenylphosphide 1,4-di-o-tosyl-2,3-isopropylidene-D-threitol 2,2-dimethoxy-propane diphenylphosphane (+)-(S,S)-2,3-dihydroxy-1,4-bis(diphenylphosphino)-butane (anti-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene)bis(diphenylphosphine oxide) {Rh((+)-diop)Cl}

合成工艺路线路线简述

    📜1,4-甲苯磺酰基-2,3-异亚丙基苏糖醇,Sodium Diphenylphosphide 以8%的收率获得
    参考文献:Green,Malcolm L. H.;Walker,Neil M.,J. Organomet. Chem.,344,(1988) N 3,379-382
    标题:Green,Malcolm L. H.;Walker,Neil M.,J. Organomet. Chem.,344,(1988) N 3,379-382

    海关参考信息

    专利信息


    专利号:US-8410320-B2
    优先权日:2010-12-07
    标 题 :Method for synthesis of secondary alcohols
    发明人:CHENG CHIEN-HONG; KARTHIKEYAN JAGANATHAN; HUANG PANG-CHI
    权利人:CHENG CHIEN-HONG; KARTHIKEYAN JAGANATHAN; HUANG PANG-CHI; NAT UNIV TSING HUA
    摘要:A method for synthesis of secondary alcohols is provided for pharmaceutical secondary alcohol by addition of organoboronic acids with aldehydes in presence of the cobalt ion and bidentate ligands as the catalyst. In addition, an enantioselective synthesis method for secondary alcohols is also herein provided in the present invention. The present invention has advantages in using less expensive cobalt ion and commercially available chiral ligands as the catalyst, wide scope of organoboronic acids and aldehydes compatible with this catalytic reaction and achieving excellent yields and/or enantiomeric excess.

    专利号:WO-2024201469-A1
    优先权日:2023-03-29
    标 题:Process for the preparation of amine intermediates
    发明人:YACOVAN AVIHAI; BAR NAHUM ITSIK; KRAKOVICH VLADA; PARNES REGEV; WANG HONGFA; ZHANG QINGLONG; Zi Weiwei
    权利人:ADAMA AGAN LTD
    摘要:The present disclosure relates a process for the preparation of amines as intermediates for the synthesis of triazines, which are suitable for use as herbicides for controlling weeds.

    专利号:US-4204997-A
    优先权日:1979-03-19
    标题 :Asymmetric amination of 1,3-dienes
    发明人:HOBBS CHARLES F; MCMACKINS DUDLEY E
    权利人:MONSANTO CO
    摘要:A process for the asymmetric synthesis of amines which comprises the amination of a conjugated diene having from 4 to about 20 carbon atoms in the presence of a catalyst system comprising a palladium compound and an optically active phosphine ligand containing at least two phosphorus atoms.

    专利号:US-8193392-B2
    优先权日:2005-07-29
    标 题:Method for enantioselective synthesis of phosphorus-stereogenic phosphines
    发明人:SCRIBAN CORINA; GLUECK DAVID S
    权利人:SCRIBAN CORINA; GLUECK DAVID S; DARTMOUTH COLLEGE
    摘要:The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.

    专利号:US-10851059-B2
    优先权日:2016-08-17
    标题:Processes and intermediates for NEP inhibitor synthesis
    发明人:KLEINBECK-RINIKER FLORIAN KARL; MAFLI IVES; MARTIN BENJAMIN; PENN GERHARD; SEDELMEIER GOTTFRIED; SEDELMEIER JOERG; VENTURONI FRANCESCO
    权利人:NOVARTIS AG
    摘要:The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

    专利号:US-6399787-B1
    优先权日:1997-06-13
    标 题:Catalytic asymmetric hydrogenation, hydroformylation, and hydrovinylation via transition metal catalysts with phosphines and phosphites
    发明人:ZHANG XUMU
    权利人:PENN STATE RES FOUND
    摘要:Novel transition metal catalysts with conformationally rigid chiral phosphines and phosphites are developed for asymmetric carbon-hydrogen and carbon-carbon bond formation. The invention emphasizes synthesis of chiral amines, beta-amino acids and related compounds via catalytic asymmetric hydrogenation based on chiral monodentate and bidentate phosphines with cyclic ring structures. The ligands contain rigid ring structures.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Łyżwa, P., Science of Synthesis Knowledge Updates, (2011) 2, 486.
    摘要:Ayad, T.; Pirat, J.-L.; Virieux, D., Science of Synthesis Knowledge Updates, (2022) 1, 297.
    摘要:Cellnik, T.; Jo, W.; Healy, A., Science of Synthesis: Knowledge Updates, (2024) 2, 340.
    摘要:Lin, Z.; Tao, R.; Zhao, Y., Science of Synthesis: Knowledge Updates, (2023) 1, 412.
    摘要:Ho, C.-Y.; Raja, D., Science of Synthesis: Knowledge Updates, (2023) 2, 329.
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