专利号:US-5110929-A 优先权日:1986-08-07 标题 :Process for the preparation of N-alkylated quaternary nitrogen containing aromatic heterocycles 发明人:PARADIES HENRICH H 权利人:MEDICE CHAM PHARM FABRIK PUTTE 摘要:The synthesis of 4-, 4-(1,1)-and 3,5-substituted N-alkyl-pyridinium salts as well as of 2-carboxamide substituted N(1,4)diazinium compounds are described. The N-surfactants obtained have a small critical micelle concentration (CMC) of 10-5 -10-7 Mol/Liter. These surfactants produce micells of different size and form depending on the nature of the anions. 4-(1,1)-substituted and 3,5-substituted N-alkyl-pyridinium components are capable of forming vesicles in equeous solutions of different forms and sizes. The N-surfactants synthesized can be used as pharmaceuticals.
专利号:CN-115340447-A 优先权日:2022-09-19 标 题:One-pot Synthesis of Two Caged Macrocyclic Aromatics and Its Separation and Purification Method
专利号:US-4093622-A 优先权日:1975-05-19 标题 :Pyridine esters of cyclopropane-carboxylic acid 发明人:HENRICK CLIVE A; STAAL GERARDUS B 权利人:ZOECON CORP 摘要:Heterocyclic organic esters and thioesters characterized by the presence of one or two cyclopropane moieties, synthesis thereof, and compositions thereof for the control of mites and ticks.
专利号:US-5112844-A 优先权日:1986-08-07 标 题:Imidazole derivatives and use as anti-bacteria, anti-fungal and anti-viral agents 发明人:PARADIES HENRICH H 权利人:PUETTER MEDICE CHEM PHARM 摘要:The synthesis of quaternary five membered N-n-alkyl-heterocycles, especially of 4-hydroxy-N(1)-n-alkyl-imidazolium, 2,5-substituted N(3)-n-alkyl-thiazolium and substituted N(2) pyrazolium salts are described. The N-surfactants obtained have a very small critical micelle concentration (CMC) of 10-5-10-7 Mol/Liter, and are capable of forming micelles of different sizes and forms depending on the nature of the anions. The N-detergents can be used as pharmaceuticals.
专利号:CN-115340447-B 优先权日:2022-09-19 标题 :One-pot synthesis of two caged macrocyclic aromatic hydrocarbons and separation and purification method thereof
专利号:US-5118808-A 优先权日:1986-08-07 标 题 :Pharmaceutical preparations 发明人:PARADIES HENRICH H 权利人:PUETTER MEDICE CHEM PHARM 摘要:The synthesis and application of N(1)-n-alkyl-pyrimidinium-salts are described. These surfactants have a very small critical micelle concentration (CMC) in the order of 10 -5 -10 -7 Mol/Liter. These N(1)-n-alkyl-pyrimidinium components have pharmacological activities and can act as antimetabolites.
参考文献:10.1186/s13568-019-0782-9 摘要:Zhao S, Hu C, Guo L, Li K, Yu H. Isolation of a 3-hydroxypyridine degrading bacterium, Agrobacterium sp. DW-1, and its proposed degradation pathway. AMB Express. 2019 May 17;9(1):65.