CAS: 32328-03-3; Diethyl 3-Hydroxyglutarate

相似化合物

91424-39-4 105-50-0 4328-94-3

上下游产品

CAS号105-50-0 丙酮二羧酸二乙酯 | CAS号1830-54-2 1,3-丙酮二羧酸二甲酯 | CAS号7250-55-7 3-羟基戊二酸二甲酯 | CAS号638-18-6 3-羟基戊二酸 | CAS号64-17-5 乙醇 | CAS号13880-89-2 3-羟基戊二腈 | CAS号77-92-9 柠檬酸 | CAS号106-95-6 烯丙基溴 | CAS号121-44-8 三乙胺 | CAS号542-05-2 1,3-丙酮二羧酸 | CAS号109462-20-6 3-[[(1,1-dimeth... | CAS号91424-39-4 3-(叔丁基二甲基硅氧基)戊二酸二乙酯 | CAS号91424-40-7 3-叔丁基二甲硅氧基戊二酸酐 | CAS号312745-91-8 (S)-4-氰基-3-羟基丁酸乙酯 | CAS号98-78-2 3-氧代-1-环戊烷羧酸 | CAS号638-18-6 3-羟基戊二酸 | CAS号7250-55-7 3-羟基戊二酸二甲酯 | CAS号1724-02-3 戊烯二酸 | CAS号113036-11-6 (R)3-乙酰氧基戊二酸单乙酯 | CAS号850872-32-1 1,5-Bis(benzylo...

1,3-丙酮二羧酸二甲酯置于氢氧化钾,Sodium Tetrahydroborate,硫酸体系中,用 甲醇 作为反应溶剂,化学反应生成 3-羟基戊二酸二乙酯
参考文献:Requirements For Stereospecificity In Hydrolysis By α-Chymotrypsin. Iv. The Hydroxyl Substituent. Absolute Configurations1
标题:Requirements For Stereospecificity In Hydrolysis By α-Chymotrypsin. Iv. The Hydroxyl Substituent. Absolute Configurations1
摘要:
DOI:10.1021/ja01481A032

专利信息

专利号:WO-2014140006-A1
优先权日:2013-03-11
标 题:Process for enantioselective synthesis of 3-hydroxy-glutaric acid monoesters and use thereof
发明人：KÖNIG BURGHARD; WETTERICH FRANK; GRÖGER HARALD; METZNER RICHARD
权利人:SANDOZ AG; UNIVERSITÄT BIELEFELD
摘要:The present invention relates to a process for the enzymatic enantioselective synthesis of 3-hydroxy- glutaric acid esters of formula 1 with R 1 being alkyl, aryl, or substituted alkyl, as well as the use compounds of formula 1 in the synthesis.

专利号:US-2005014954-A1
优先权日:2001-11-22
标 题:Pyrrole synthesis
发明人：OHRLEIN REINHOLD; BAISCH GABRIELE
摘要:The invention relates to a novel process for the preparation of N-substituted pyrroles, especially of formula (V), wherein the radicals are as defined in the description, by intermolecular aza-Wittig reaction starting from organic azides and 1,4-dioxo compounds. The invention relates also to novel iminophosphorane intermediates for this synthesis. The resulting pyrroles are useful, for example, in the organic synthesis of pharmaceuticals or other active substances and chemicals.

专利号:US-8026383-B2
优先权日:2001-07-06
标题:Process for the preparation of intermediates useful in the synthesis of statin derivatives
发明人：OEHRLEIN REINHOLD; BAISCH GABRIELE; END NICOLE; BURKHARDT STEPHAN; STUDER MARTIN
权利人:BASF SE
摘要:The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I n nwherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH 3 )OCH 3 , R a is a hydroxy-protecting group and R b is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.

专利号:US-7692034-B2
优先权日:2001-07-06
标题:Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
发明人：OEHRLEIN REINHOLD; BAISCH GABRIELE; KIRNER HANS JUERG; BIENEWALD FRANK; BURKHARDT STEPHAN; STUDER MARTIN
权利人:TEVA PHARMA
摘要:The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein R a and R c are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and R b is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein R a and R c are each independently of the other hydrogen or a hydroxy-protecting group, and R b is a carboxy-protective group.

专利号:US-7504532-B2
优先权日:2001-07-06
标 题 :Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation
发明人：OEHRLEIN REINHOLD; BAISCH GABRIELE; KIRNER HANS JOERG; BURKHARDT STEPHAN; STUDER MARTIN; BIENEWALD FRANK
权利人:TEVA PHARMA
摘要:Synthesis methods for the preparation of intermediates which are suitable for the preparation of statin derivatives, and especially to synthesis methods for the intermediate of formula (VI) wherein R a ′ and R c ′ are each independently of the other hydrogen or hydroxy-protecting group, or together are a bridging hydroxy-protecting group; and R b is a carboxy-protecting group.

专利号:US-7420078-B2
优先权日:2001-07-06
标 题 :Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof