CAS: 32175-00-1; Trans-4-Methylcyclohexylisocyanate

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2523-55-9 6321-23-9 33483-65-7

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CAS号75-44-5 光气 | CAS号2523-55-9 反式 4-甲基环己胺 | CAS号93479-97-1 格列美脲 | CAS号33073-59-5 1-(2-Chloroethy... | CAS号33059-82-4 1-(2-chloroethy...

专利信息

专利号:US-2007082943-A1
优先权日:2005-04-01
标 题:Process for preparation of substantially pure glimepiride
发明人：KADAM SURESH M; TARUR VENKATASUBRAMANIAN R; NAIK SANJAY J; GAVHANE SACHIN B
权利人:KADAM SURESH M; TARUR VENKATASUBRAMANIAN R; NAIK SANJAY J; GAVHANE SACHIN B
摘要:The present invention discloses a novel process for purification of trans-4-methyl cyclohexylamine HCl and 4[-2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide used in the synthesis of 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methyl cyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide (I), popularly known as Glimepiride. The present invention also discloses a novel purification of Glimepiride usingS methanolic ammonia and glacial acetic acid to obtain highly pure Glimepiride Form I (I) having the undesired cis isomer below 0.15%. Glimepiride (I) is useful in the treatment of diabetes mellitus.

专利号:US-11028214-B2
优先权日:2018-01-22
标题 :Synthesis of oligomer for optical fiber coating
发明人：CHEN YANGBIN; YANG BIN
权利人:CORNING INC
摘要:A method for making oligomers is described. The method includes reacting a polyol with a precursor having mixed functionality. The precursor includes a curable functional group and an isocyanate group capable of reacting with an alcohol group of the polyol. The precursor reacts with the alcohol group of the polyol to form a urethane linkage and to add a covalently bonded curable functional group to the polyol. The oligomers can be included in coating compositions for optical fiber and lead to coatings having improved tear strength.

专利号:US-2022281888-A1
优先权日:2019-09-25
标题:Bicyclic carboxylates as modulators of transporters and uses thereof
发明人：SANDANAYAKA VINCENT; GORECZNY GREGORY
权利人:NIROGY THERAPEUTICS INC
摘要:The present invention generally relates to the field of transporter modulators, e.g., monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.

专利号:US-2019225732-A1
优先权日:2018-01-22
标题 :Synthesis of oligomer for optical fiber coating

专利号:CZ-2005230-A3
优先权日:2005-04-12
标题:A novel method for the synthesis of trans-4-methylcyclohexylamine base and derived salts of the hydrochloride or pivalate of trans-4-methylcyclohexylamine useful as an intermediate for the production of the antidiabetic glimepiride

专利号:SK-50312006-A3
优先权日:2005-04-12
标题:A novel process for the synthesis of trans-4-methylcyclohexylamine base and the trans-4-methylcyclohexylamine hydrochloride or pivalate derivative salts useful as intermediates for the production of the glimepiride antidiabetic agent