CAS: 24404-53-3; (2R,3S,4S,5R,6S)-2-(Acetoxymethyl)-6-(Phenylthio)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate

相似化合物

23661-28-1 108032-93-5 16758-34-2

上下游产品

(2R,3S,4S,5R,6S)-2-Hydroxymethyl-6-phenylsulfanyl-tetrahydro-pyran-3,4,5-triol acetic anhydride thiophenol 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide(2R,3S,4S,5R,6S)-2-Hydroxymethyl-6-phenylsulfanyl-tetrahydro-pyran-3,4,5-triol phenylsulfonyl 2,3,4,6-tetra-O-acetyl-1-deoxy-β-D-glucopyranoside tetra-O-acetyl-1-O-methyl-β-D-glucopyranose methyl 6-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2,3,4-tri-O-benzyl-α-D-glucopyranoside

Beta-D-半乳糖五乙酸酯置于三氟化硼乙醚体系中,用 二氯甲烷,甲苯 用作溶剂,化学反应 23.0H,反应生成2,3,4,6-O-四乙酰基-1-硫代-β-D-苯基半乳糖苷
参考文献:对甲氧基苯基糖苷转化为相应的糖基氯化物和溴化物,并转化为硫代苯基糖苷.
标题:对甲氧基苯基糖苷转化为相应的糖基氯化物和溴化物,并转化为硫代苯基糖苷.
摘要:使用硼从相应的1-O-乙酰基糖中制备对甲氧基苯基(pmp)β-D-吡喃葡萄糖苷(glc,Gal,Glcnphth,Galnphth,Glcntr°C,Gal Beta 4Glc,Gal Alpha 4Gal),使用硼制得三氟化醚醚为助催化剂.在各种路易斯酸的存在下用酰氯或溴化物处理pmp糖苷得到相应的糖酰氯和溴化物,产率为81-98%.用硫酚和三氟化硼醚化物处理酰基保护的pmp糖苷,可以80-100%的收率和高(> 20:1)β/ Alpha选择性获得相应的硫糖苷.针对一系列试剂研究了pmp糖苷的稳定性.
Doi:10.1016/s0008-6215(96)90118-4

专利信息

专利号:US-2014323705-A1
优先权日:2011-05-13
标题:Manufacture of lacto-n-tetraose
发明人：HEDEROS MARKUS; DEKANY GYULA; DEMKÓ Sà NDOR; Kovács Imre; BAJZA ISTVà N
权利人:HEDEROS MARKUS; DEKANY GYULA; DEMKÓ Sà NDOR; Kovács Imre; BAJZA ISTVà N
摘要:The present invention relates to the synthesis of the tetrasaccharide of formula (I) and novel intermediates used in the synthesis.