CAS: 1400-61-9; Nystatin

专利信息

专利号:US-7851183-B2
优先权日:2000-02-08
标 题:Genes encoding a nystatin polyketide synthase and their manipulation and utility
发明人：ZOTCHEV SERGEY BORISOVICH; SEKUROVA OLGA NIKOLAYIVNA; FJAERVIK ESPEN; BRAUTASET TRYGVE; STROEM ARNE REIDAR; VALLA SVEIN; ELLINGSEN TROND ERLING; SLETTA HAAVARD; GULLIKSEN OLE-MARTIN
权利人:SINVENT AS
摘要:The invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 35; or (b) a nucleotide sequence which is the complement of SEQ ID No. 35; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 35; or (d) a nucleotide sequence hybridising under conditions of high stringency to SEQ ID No. 35, to the complement of SEQ ID No. 35, or to a hybridisation probe derived from SEQ ID No. 35 or the complement thereof; or (e) a nucleotide sequence having at least 80% sequence identity with SEQ ID No. 35; or (f) a nucleotide sequence having at least 65% sequence identity with SEQ ID No. 35 wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof. Also provided are part of such molecules and polypeptides (and parts thereof) encoded by such a nucleic acid molecule, and the use of such molecules and polypeptides in facilitating nystatin biosynthesis and in the synthesis of nystatin derivatives and novel polyketide as macrolide structures.

专利号:KR-20020060242-A
优先权日:1999-11-29
标题:Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use in synthesis of novel compounds

专利号:CN-117136305-A
优先权日:2021-03-31
标 题 :Synthesis of functionalized polypeptide nanopores using positively charged substances and methods for their preparation and use

专利号:WO-2007023370-A1
优先权日:2005-08-24
标题:Compositions and methods for treating malaria
发明人：HOPPE HEINRICH CARL; RAUTENBACH MARINA; WIEHART URSULA ISABELLA MANYA
权利人:UNIV STELLENBOSCH; UNIV CAPE TOWN; HOPPE HEINRICH CARL; RAUTENBACH MARINA; WIEHART URSULA ISABELLA MANYA
摘要:Polyene macrolide compounds, analogues thereof and compositions containing polyene macrolides or analogues are described for use in treating malaria infections in humans and animals. Examples of polyene macrolide compounds are amphotericin B, nystatin A, natamycin (pimaricin), filipin, rimocidin, candidin and vacidin, and in particular, formulations similar to those described for amphotericin B, such as amphotericin B deoxycholate, amphotericin B colloidal dispersion, amphotericin B lipid complex and liposomal amphotericin B. The polyene macrolide may be produced by a microorganism, by chemically modifying a polyene macrolide or via de novo synthesis. The analogue may be chemically modified to improve solubility, bio-availability and/or bio-activity or limit toxicity. The polyene macrolide or analogue may be administered together with one or more other antimalarial compounds, such as chloroquine, quinine, quinidine, mefloquine, halofantrine, sulfonamides, tetracyclines, atovaquone, artemisinin compounds, rimaquine, proguanil or pyrimethamine, so as to increase the efficacy of the other antimalarial compound.