CAS: 135065-71-3; (R)-Tert-Butyl 2-(Hydroxymethyl)Morpholine-4-Carboxylate

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号156925-22-3 R-(吗啉-2-基)甲醇 | CAS号884512-77-0 (2R)-2,4-吗啉二羧酸4-叔丁酯 | CAS号135065-70-2 (R)-2-((苄氧基)甲基)吗啉 | CAS号913642-85-0 (R)-N-B°C-2-吗啉甲醛 | CAS号884512-77-0 (2R)-2,4-吗啉二羧酸4-叔丁酯 | CAS号879403-42-6 (S)-N-B°C-2-氨甲基吗啉 | CAS号919286-58-1 (R)-2-(溴甲基)吗啉-4...

N-(2-Hydroxyethyl)-N-{(2R)-2-Hydroxy-3-[(Phenylmethyl)Oxy]Propyl}-4-Methylbenzenesulfonamide置于palladium 10% On Activated Carbon 萘,氢气,Sodium,Sodium Hydride体系中,用 四氢呋喃,正己烷,乙酸乙酯,Mineral Oil 用作溶剂,20.0 °C,101.33 Kpa 条件下,反应 145.08H,反应生成(R)-N-Boc-2-羟甲基吗啉
参考文献:Wo2008/157330
标题:Wo2008/157330

专利信息

专利号:US-2023150994-A1
优先权日:2020-04-07
标 题:Methods for synthesis of chk1 inhibitors
发明人：SCHWAEBE MICHAEL; ROSNER THORSTEN; ZHAO DALIAN; MILLER ROSS; DULINA RICH; HUMORA MICHAEL; GOTTSCHLING STEPHEN E
权利人:SIERRA ONCOLOGY INC
摘要:The present technology relates to processes, compounds, compositions, and methods useful for coupling reactions. Also, the present disclosure provides for novel intermediates, compositions of matter, and processes relating to the Chk1 inhibitor, SRA737.

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:WO-2024042471-A1
优先权日:2022-08-25
标 题 :Preparation of a p2x3 antagonist
发明人：VILLENEUVE KARINE; KRONENTHAL DAVID R
权利人:14245563 CANADA INC
摘要:Described herein are processes for the synthesis of P2X3 antagonists, wherein the P2X3 antagonist is methyl (S)-2-((2-(2,6-difluoro-4- (methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate (Compound 1), or a pharmaceutically acceptable salt or co-crystal thereof.

专利号:US-2024383920-A1
优先权日:2023-04-14
标 题:Synthesis of ras inhibitors
发明人：LI SHAOLING; LL YI; LOBBEN PAUL; WANG ROSS; BALLMER STEVE; HUANG XIAOJUN
权利人:REVOLUTION MEDICINES INC
摘要:The present invention relates to Ras inhibitors and to methods for preparing Ras inhibitors.

专利号:WO-2024216008-A1
优先权日:2023-04-14
标题 :Synthesis of ras inhibitors

专利号:EP-4132922-A1
优先权日:2020-04-07
标 题 :Methods for synthesis of chk1 inhibitors