CAS: 127785-64-2; (3S,6S,9S,12S,15R,18S,21S,24S,29As)-21,24-Dibenzyl-3,15-Di((R)-Sec-Butyl)-12-(2-Hydroxypropan-2-yl)-9-Isobutyl-6,18-Diisopropyl-5,11,17,23-Tetramethyloctadecahydro-1H,15H-Pyrrolo[1,2-M][1]Oxa[4,7,10,13,16,19,22,25]Octaazacycloheptacosine-1,4,7,10,13,16,19,22,25-Nonaone

上下游产品

quinoline-2-carboxylic acid 2-[3(S)-[(L-asparaginyl)-amino]-2(R)-hydroxy-4-phenylbutyl]-N-tert-butyl-decahydro(4aS,8aS)-isoquinoline-3(S)-carboxamide (2S)-2-[(quinoline-2-carbonyl)-amino]-succinamic acid -(4aS,8aS)-isoquinoline-3(S)-carboxamidecis-N-butyldecahydro-2-2(R)-hydroxy-4-phenyl-3(S)-aminobutyl-(4aS,8aS)-isoquinoline-3(S)-carboxamide

专利信息

专利号:US-2024336559-A1
优先权日:2021-10-06
标 题 :Anti-fungals compounds targeting the synthesis of fungal sphingolipids
发明人：OJIMA IWAO; HARANAHALLI KRUPANANDAN; DEL POETA MAURIZIO; GARG ASHNA
权利人:UNIV NEW YORK STATE RES FOUND
摘要:The present invention provides a compound having the structure: n n n n n n n n n n n n wherein n R 3 , R 4 , R 5 , R 6 , and R 7 are each independently, H, halogen, CN, —CF 3 , —OCF 3 , —NO 2 , alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, —OH, —OAc, —OR 13 , —COR 13 , —CH 2 OR 13 , —SH, —SR 13 , —SO 2 R 13 , —NH 2 , —NHR 13 , —NR 14 R 15 , —NHCOR 12 , or —CONR 14 R 15 ; n R 9 , R 10 , R 11 , and R 12 are each independently, H, CN, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, —OAc, —COR 13 , —SH, —SR 13 , —SO 2 R 13 , —NH 2 , —NHR 13 , —NR 14 R 15 , —NHCOR 12 , or —CONR 14 R 15 ;n wherein each occurrence of R 13 is independently alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R 14 is independently —H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R 15 is independently —H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, n n wherein when R 14 is methyl, R 15 is not methyl; n wherein at least one of R 9 , R 10 , R 11 , and R 12 is not H; n wherein at least one of R 3 , R 4 , R 5 , R 6 , and R 7 is not H.

专利号:US-2011318792-A1
优先权日:2006-08-15
标题 :Novel method for utilization of microbial mutant
发明人：OHSUGA TOSHIO; FUSHIKIDA KUNI
权利人:OHSUGA TOSHIO; FUSHIKIDA KUNI; ISHIHARA SANGYO KAISHA
摘要:The object of the present invention is to provide a microbial mutant capable of producing S-adenosylmethionine (hereinafter referred to as SAM) in a large amount with no change in growth characteristics and a method of efficiently producing SAM by incubating the microbial mutant. n The method of producing S-adenosylmethionine comprises incubating a microorganism having a loss or a reduction in the function of an enzyme relating to synthesis of phosphatidylcholine and recovering S-adenosylmethionine accumulated in the culture.

专利号:US-2016369268-A1
优先权日:2013-07-01
标题:Transcription activator-like effector (tale) libraries and methods of synthesis and use
发明人：BLERIS LEONIDAS G; LI YI
权利人:THE BOARD OF REGENTS OF THE UNIV OF TEXAS SYSTEMS; UNIV TEXAS
摘要:Disclosed herein are transcription activator-like effector (TALE) libraries that consist of all possible combinations of tandem repeats and methods of making and using the same.

专利号:US-11946086-B2
优先权日:2017-01-05
标题 :Gene involved in synthesis of cyclic peptide compound, method for producing cyclic peptide compound using the same, and transformant comprising the same
发明人：KUBO TAKASHI; MACHIDA MASAYUKI; UMEMURA MAIKO; ABE KEIETSU; YOSHIMI AKIRA; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI
权利人:AIST; UNIV TOHOKU; KUMIAI CHEMICAL INDUSTRY CO
摘要:This invention is intended to identify a gene cluster involved in biosynthesis of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species and to establish a system for synthesizing such cyclic peptide compound. The gene is composed of a first module to a tenth module and encodes a protein having activity of synthesizing a nonribosomal peptide constituting a basic peptide backbone of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species.

专利号:US-12325678-B2
优先权日:2017-06-16
标 题 :Anti-fungals compounds targeting the synthesis of fungal sphingolipids
发明人：OJIMA IWAO; DEL POETA MAURIZIO; LAZZARINI CRISTINA; HARANAHALLI KRUPANANDAN; SUN YI
权利人:UNIV NEW YORK STATE RES FOUND
摘要:The present invention provides a compound having the structure: n nand use of the compound for inhibiting the growth of or killing.

专利号:US-10851393-B2
优先权日:2015-02-24
标 题:KAS-III free FA synthesis
发明人：SAN KA-YIU; ZHANG XIAN; WU HUI; WANG DAN
权利人:UNIV RICE WILLIAM M
摘要:The present disclosure describes a genetically engineered a KASIII-independent fatty acid biosynthetic pathway that makes use of the promiscuous nature of the rest of the FAS enzymes (3-ketoacyl-ACP synthetase, 3-ketoacyl-ACP reductase, 3-hydroxyacyl ACP dehydrase, enoyl-ACP reductase) to bypass the KASIII step by providing a Co-A precursor of two or higher than two carbons (such as the four carbon butyryl-CoA) as the starting molecule. Since many CoA-based starter molecules can be supplied for the fatty acid synthesis, much more diversified products can be obtained with various carbon-chain lengths. As such, this disclosure will serve as a powerful and efficient platform to produce low to medium chain length products carrying many different functional groups.