CAS: 120568-11-8; 5-(4'-Methyl-2-Biphenylyl)-1H-Tetrazole

上下游产品

2-Cyano-4'-methylbiphenyl -2-(trimethylstannyl)-2H-tetrazole5-4'-Methyl-1,1'-biphenyl-2-yl-2-(trimethylstannyl)-2H-tetrazole -1H-tetrazole-1-propanenitrile5-4'-Methyl-1,1'-biphenyl-2-yl-1H-tetrazole-1-propanenitrile N-triphenylmethyl-5-(4'-methylbiphenyl-2-yl)tetrazole N-(trityl)-5-[4-(methyl)biphenyl-2-yl]-2H-tetrazole

📜厄贝沙坦 以 Phosphate Buffer 用作溶剂,化学反应生成4'-甲基联苯四氮唑
参考文献:Mbah,Pharmazie,2004,Vol. 59,# 12,P. 920-922
标题:Mbah,Pharmazie,2004,Vol. 59,# 12,P. 920-922

专利信息

专利号:US-2008214637-A1
优先权日:2004-11-11
标题 :Process for the Synthesis of Tetrazoles
发明人：ANTONCIC LJUBOMIR; LUDESCHER JOHANNES
权利人:LEK PHARMACEUTICALS
摘要:A process for the synthesis of tetrazol derivative has been developed which starts from a tetrazole derivative where acidic hydrogen atom has been replaced by a protecting group and the deprotection is performed with a catalytic amount of organic acid and can proceed in an aqueous solvent.

专利号:US-5039814-A
优先权日:1990-05-02
标 题:Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
发明人：SHUMAN RICHARD F; KING ANTHONY O; ANDERSON ROBERT K
权利人:MERCK & CO INC
摘要:A process utilizes the tetrazole functional group to direct lithiation at the ortho position of a phenyltetrazole and generate a nucleophilic aryllithium species which then undergoes reaction with an electrophile to generate a 2-substituted 1-(tetrazol-5-yl)benzene. The process is useful in the production of intermediates in the synthesis of angiotensin II antagonists. This novel process is a more cost effective and versatile route for the large-scale preparation of these key intermediates.

专利号:US-6326498-B1
优先权日:2001-03-13
标 题 :Process for the synthesis of 5-(2-flurophenyl)-1H-tetrazole
发明人：MALLADI PARDHASARADHI; KANTEVARI SRINIVAS; NAIR CHEMBUMKULAM KAMALAKSHYAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses a process of the preparation of 5-(2-flurophenyl)-1H-tetrazole of the formula 2 by reacting 2-fluoro benzonitrile of the formula 1 n with an inorganic azide and an amine salt in an aromatic solvent, precipitating the product with hydrochloric acid and separating the precipitated product.

专利号:WO-2008012852-A1
优先权日:2006-07-27
标 题:Intermediate compounds for the preparation of angiotensin ii antagonists
发明人：GUANDALINI LUCA; MARTINI ELISABETTA; ROMANELLI MARIA NOVELLA; DALLATOMASINA FRANCO
权利人:S I M S S R L SOC IT MEDICINAL; GUANDALINI LUCA; MARTINI ELISABETTA; ROMANELLI MARIA NOVELLA; DALLATOMASINA FRANCO
摘要:The present invention relates to novel substituted biphenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists, to a process for the synthesis of them and to a process for the conversion thereof to said molecules.

专利号:WO-9637481-A1
优先权日:1995-05-26
标题:Novel reagent for tetrazole synthesis and process for producing tetrazoles therewith
发明人：TOKUHARA GINRO; YAMAGUCHI TADASHI; IWASAKI TETSUYA
权利人:CHUGOKU KAYAKU; WAKUNAGA SEIYAKU KK; TOKUHARA GINRO; YAMAGUCHI TADASHI; IWASAKI TETSUYA
摘要:A process for producing 1H-tetrazoles represented by general formula (II) (wherein R represents an arbitrary substituent) from carbonitriles represented by the general formula (I): R-CN (wherein R is as defined above) with the use of a tetrazolating agent comprising an alkali metal azide and zinc chloride. The agent can be used in a variety of solvents and can fundamentally be applied to any carbonitriles. As zinc chloride is inexpensive, it contributes to cost reduction.

专利号:US-5371233-A
优先权日:1991-12-30
标 题:2-(tetrazol-5-yl)-1,1'-biphenyl derivatives, their preparation and their use as synthetic intermediates
发明人：DAUMAS MARC; HOORNAERT CHRISTIAN; CHEKROUN ISAAC; BEDOYA-ZURITA MANUEL; RUIZ-MONTES JOSE; ROSSEY GUY; GRECIET HELENE
权利人:SYNTHELABO
摘要:Compounds corresponding to the formula (I) ##STR1## in which X represents dibromomethyl, formyl, (C 1-4 )alkyl, or a group CH(OR 5 ) 2 or CH(OH)OR 5 , wherein the or each R 5 is hydrogen (C 1-3 )alkyl or the two R 5 's in the case of CH(OR 5 ) 2 are linked to provide a 1,3-dioxolane or 1,3-dioxane ring, and Y represents hydrogen, 1,1-dimethylethyl, triphenylmethyl, trimethylstannyl, tributylstannyl, (1,1-dimethylethyl)dimethylsilyl, (1,1-dimethylethyl)diphenylsilyl, 2-cyanoethyl, or a group CH 2 OR 6 wherein R 6 is methyl, phenylmethyl, 1,1-dimethylethyl, 2,2,2-trichloroethyl, benzyloxycarbonyl or 2,2,2-trichloroethyloxycarbonyl, Y being in position 1 or 2 on the tetrazole ring. The compounds of formula (I) are useful as intermediates in the synthesis of compounds possessing therapeutic activity.