专利号:US-6818394-B1 优先权日:1996-11-06 标题:High density immobilization of nucleic acids 发明人:O'DONNELL-MALONEY MARYANNE J; CANTOR CHARLES R; KOESTER HUBERT 权利人:SEQUENOM INC 摘要:Processes and kits for immobilizing a high density of nucleic acids on an insoluble surface, which are particularly useful for mass spectrometric detection of nucleic acids, are disclosed. Arrays containing the immobilized nucleic acids and use of the immobilized nucleic acids in a variety of solid phase nucleic acid chemistry applications, including nucleic acid synthesis (chemical and enzymatic), hybridization and/or extension, and sequencing, are provided. Serial and parallel dispensing tools that can deliver defined volumes of fluid to generate multi-element arrays of sample material on a substrate surface are further provided. Tools provided herein can include an assembly of vesicle elements, or pins, wherein each of the pins can include a narrow interior chamber suitable for holding nanoliter volumes of fluid. Methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface are also provided. The tool can dispense a spot of fluid to a substrate surface by spraying the fluid from the pin, contacting the substrate surface or forming a drop that touches against the substrate surface. The tool can form an array of sample material by dispensing sample material in a series of steps, while moving the pin to different locations above the substrate surface to form the sample array, The prepared sample arrays may be passed to a plate assembly that disposes the sample arrays for analysis by mass spectrometry.
专利号:NZ-330610-A 优先权日:1994-01-21 标题 :Use of aminoguanidine derivatives to inhibit synthesis of urea from plasma arginine
专利号:CN-111808902-B 优先权日:2019-04-10 标题 :C-glycosyltransferase and application thereof in synthesis of schaftoside and isoschaftoside
专利号:CN-105461527-A 优先权日:2015-12-24 标 题 :Synthesis method of efloxate drug intermediate 3, 4-dihydroxyacetophenone
专利号:US-7427690-B2 优先权日:2004-06-05 标 题 :Multifunction “crown complexesâ€? from amino acids and peptides for skin and hair restoration 发明人:GUPTA SHYAM K 权利人:BIODERM RESEARCH 摘要:This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.
[参考文献]: Xiao Ruan, Et Al. Autotoxicity And Allelopathy Of 3,4-Dihydroxyacetophenone Isolated From Picea Schrenkiana Needles. Molecules. 2011 Oct 24;16(10):8874-93. [参考文献]: You Jung Kim, Et Al. Antimelanogenic Activity Of 3,4-Dihydroxyacetophenone: Inhibition Of Tyrosinase And Mitf. Biosci Biotechnol Biochem. 2006 Feb;70(2):532-4.
合成参考文献
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