奥洛他定丁酯置于potassium Hydroxide,Sodium Hydroxide,盐酸体系中,用 水,甲苯,丙酮 用作溶剂,化学反应 4.0H,反应生成奥洛他定 参考文献: Process For The Preparation Of Olopatadine[fr] Procédé De Préparation De L'Olopatadine 标题: Process For The Preparation Of Olopatadine[fr] Procédé De Préparation De L'Olopatadine
专利号:US-9562030-B2 优先权日:2013-03-19 标题:Process for the synthesis of olopatadine 发明人:CHAVAN SUBHASH PRATAPRAO; LASONKAR PRADEEP BHASKARRAO 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides a process for the synthesis of olopatadine. Further, the invention discloses a process that results in improved yield of the desired Z isomer.
专利号:WO-2023075715-A1 优先权日:2021-10-26 标题 :A pharmaceutical formulation including leukotriene receptor antagonists and/or leukotriene synthesis inhibitors combined with non-steroidal anti-inflammatory drugs (nsaids) 发明人:OYTUN FARUK; CAN EFE 权利人:VSY BIYOTEKNOLOJI VE ILAC SANAYI ANONIM SIRKETI 摘要:This invention is related to a pharmaceutical formulation including Leukotriene receptor antagonists and/or Leukotriene synthesis inhibitors combined with non-steroidal anti-inflammatory drugs (NSAIDs) and antihistamines in ocular diseases and in inflammatory and allergic diseases for systemic and topical use. The objective of this invention is to create a novel formulation to be effective as much as steroids while having significantly less side effects for long-term use in treating ocular diseases, inflammatory and allergic diseases. In other words our aim is to achieve the inhibition of pro-inflammatory mediators (prostaglandins, thromboxane, histamine and leukotrienes) as much as steroids do with a safer combination.
专利号:US-2016280677-A1 优先权日:2013-03-19 标 题:A process for the synthesis of olopatadine
专利号:WO-2014147647-A1 优先权日:2013-03-19 标 题:A process for the synthesis of olopatadine
专利号:US-2013030282-A1 优先权日:2011-07-18 标题:Synthesis and characterization of near ir fluorescent magnetic and non-magnetic albumin nanoparticles for biomedical applications 发明人:MARGEL SHLOMO; COHEN SARIT; SALKMON ENAV COREM; PELLACH MICHAL 权利人:UNIV BAR ILAN; MARGEL SHLOMO; COHEN SARIT; SALKMON ENAV COREM; PELLACH MICHAL 摘要:The present invention discloses Near Infrared (NIR) fluorescent albumin nanoparticles having a structure selected from a core structure or a core-shell structure. Also disclosed are a process of preparing these NIR fluorescent albumin nanoparticles, and a method of in vivo detection of pathologies, in particular cancer pathology, by using administering these NIR fluorescent albumin nanoparticles to a patient.
专利号:US-2007148246-A1 优先权日:2005-08-11 标题:Nucleic Acid-Based Matrixes 发明人:LUO DAN; LI YOUGEN 权利人:LUO DAN; LI YOUGEN 摘要:Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include delivery of biologically active agents, cell and tissue culture, and cell-free protein synthesis.
1: Mostafa IM, Omar MA, Noureldeen DAM, Zeid AM, Halawa MI, Mohamed AA. Green and sensitive detection of olopatadine in aqueous humor using a signal-on fluorimetric approach: GREEnness assessment. Luminescence. 2024 Jul;39(7):e4814. doi: 10.1002/bio.4814. 16(6):2501-2508. doi: 10.62347/XMFX3074. 3: Nakagawa N, Kashiwabara M, Egawa K, Sasaki A. Cost-effectiveness Analysis of Second-Generation Antihistamine 1 Receptor Blockers and Japanese Kampo Shoseiryuto for Treating Perennial Allergic Rhinitis in Outpatient Settings in Japan. Hosp Pharm. 2024 Aug;59(4):436-443. doi: 10.1177/00185787241229152. Epub 2024 Feb 18. 4: Samoliński B, Wojas O, Lipiec A, Krzych-Fałta E, Walkiewicz A, Borowicz J, Samoliński K. Intranasal combo: fixed-dose combination of mometasone furoate and olopatadine hydrochloride in therapeutic strategies for rhinosinusitis. Otolaryngol Pol. 2023 Dec 4;77(6):43-50. doi: 10.5604/01.3001.0054.0941. 40(2):126-135. doi: 10.1089/jop.2023.0111.
合成参考文献
摘要:S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (2021) DOI:10.1021/acsenvironau.1c00008. List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355