CAS: 1128-74-1; 7-Fluoro-2-Methylquinoline

相似化合物

1128-61-6 46001-36-9 1128-74-1

上下游产品

CAS号66023-21-0 2-甲基-6-(三氟甲基)喹啉 | CAS号372-19-0 3-氟苯胺 | CAS号109-92-2 乙烯基乙醚 | CAS号123-73-9 2-丁烯醛 | CAS号91-63-4 2-甲基喹啉

7-氟-2-甲基-1,2,3,4-四氢喹啉置于iron Oxide Surrounded By Nitrogen Doped Graphene Shell Immobilized On Carbon Support体系中,用 正庚烷 用作溶剂,100.0 °C,1.5 Mpa 条件下,反应 12.0H,以75%的收率获得7-氟-2-甲基喹啉
参考文献:铁氮掺杂石墨烯/核壳催化剂的合成和表征:N-杂环的高效氧化脱氢
标题:铁氮掺杂石墨烯/核壳催化剂的合成和表征:N-杂环的高效氧化脱氢
摘要:纳米催化的一个重要目标是开发灵活有效的方法来制备活性稳定的核壳催化剂.在这方面,我们介绍了由固定在碳载体上的氮掺杂石墨烯壳包围的氧化铁的合成和表征(标记为 Feox@ngr-C).通过醋酸铁和菲咯啉的热解和随后的选择性浸出,以简单,可扩展的两步法获得活性催化材料.优化的 Feox@ngr-C 催化剂在几种 N-杂环的氧化脱氢中表现出高活性.药学相关喹啉的合成证明了这种良性方法的效用.此外,机理研究证明反应通过超氧自由基阴离子(.o2(-))进行.
Doi:10.1021/jacs.5B05674

专利信息

专利号:US-6552018-B1
优先权日:1997-01-27
标 题:Pyrazole derivatives
发明人：EJIMA AKIO; OHSUKI SATORU; OHKI HITOSHI; NAITO HIROYUKI
权利人:DAIICHI SEIYAKU CO
摘要:The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): n wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: n These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)- 1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.