CAS: 1086-80-2; 7,8-Dimethylbenzo[g]Pteridine-2,4(1H,3H)-Dione

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BARBITURIC ACID 5,5-Dichloro-barbituric acid 4,5-dimethyl-1,2-phenylenediamine 4,5-dimethyl-2-nitrobenzenamine1,3-dimethyllumichrome 6,7-dimethyl-quinoxalin-2-ylamine

📜1,4-二巯基-2,3-丁二醇置于盐酸,Naoh体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应生成光色素
参考文献:Flavin-Nucleic Acid Ligand Conjugates
标题:Flavin-Nucleic Acid Ligand Conjugates
摘要:该发明涉及黄素-Nal共轭物及其在遗传工程领域中的应用.根据与nal共轭的黄素的性质,根据本发明的共轭物可以用作(1)在活细胞中特异和高效地切割靶核酸序列的核酸酶,或者(2)用作特异和高效地将nal(例如反义寡核苷酸)引入细胞内的载体.

专利信息

专利号:WO-2025149479-A1
优先权日:2024-01-12
标题:Synthesis of modified nucleoside triphosphates
发明人：KUCHELMEISTER HANNES; PFAFFENEDER TONI; MEX MARTIN; VETH SIMON; MENKE JAN-MICHAEL
权利人:ROCHE DIAGNOSTICS GMBH
摘要:The invention relates to a new diastereoselective synthesis method for highly modified nucleoside triphosphates with two conjugable groups. The method works in liquid phase with conventional laboratory equipment as used in any chemical laboratory or production. For this, a new chiral P(V) phosphorylation reagent has been designed that allows highly efficient diastereoselective synthesis under mild conditions. Overall, a highly efficient, diastereoselective, high quality, cost-effective synthetic method of modified nucleoside triphosphates has been developed.

专利号:US-2025154548-A1
优先权日:2023-11-09
标 题:Control of enzymatic nucleic acid synthesis via electrochemical means
发明人：BRYAN CASSIE M; SPRACHMAN MELISSA; DOYLE ROBERT; RECORDS WILLIAM C
权利人:CHARLES STARK DRAPER LABORATORY INC
摘要:Provided herein are methods of nucleic acid synthesis. In some embodiments, a method of nucleic acid synthesis comprises selectively activating and deactivating an engineered terminal deoxynucleotidyl transferase (TdT). In some embodiments, a method of nucleic acid synthesis comprises activating a pH sensitive enzyme to digest and remove a TdT.

专利号:CN-1257144-C
优先权日:2004-05-18
标题:1,4-bis(4-fluorophenylcarbonyl)naphthalene, its synthesis method and its application in the synthesis of polymer materials

专利号:WO-2025006460-A9
优先权日:2023-06-30
标题:Systems and methods of sequencing polynucleotides with modified bases
发明人：LU BO; WEI WEI; GOH HUI KHENG KAREN; VIECELI JOHN SILVIO; TEO YIN NAH
权利人:ILLUMINA INC
摘要:Described are DNA sequencing systems and methods. Systems and methods for determining the nucleotide sequence of a polynucleotide may include determining the sequence of a polynucleotide with more than four types of bases by increasing the number of encoding states in sequencing by synthesis (SBS) systems. The systems and methods may expand the encoding space of current systems by discretizing the amplitude space in a channel into more than two states, and/or by adding additional channels.

专利号:US-10774105-B2
优先权日:2014-11-20
标题:Phosphoroamidate esters, and use and synthesis thereof
发明人：KOKORIS MARK STAMATIOS; TABONE JOHN; NABAVI MELUD; JACOBS AARON
权利人:STRATOS GENOMICS INC
摘要:Phosphoramidate esters and related nucleotide analogs useful in polynucleotide sequencing techniques, and synthetic methods for preparing those compounds, are disclosed, including compounds having the following structure: n nwherein R 1 , R 2 , R 3 and R 4 are as defined herein. These compounds include nucleotide phosphoramidates analogs that are modified on the alpha-phosphate to enable attachment of a variety of application-specific substituents such as tether molecules.

专利号:WO-2025006466-A1
优先权日:2023-06-30
标 题:Systems and methods of sequencing polynucleotides with four labeled nucleotides
发明人：KAGALWALLA ABDE ALI HUNAID; VIECELI JOHN SILVIO
权利人:ILLUMINA INC
摘要:The application relates to DNA sequencing systems and methods. Systems and methods for determining the nucleotide sequence of a polynucleotide may include introducing a fourth labeled nucleotide in a two-channel sequencing by synthesis system that allows for encoding space for a detecting a fifth labeled nucleotide or empty well detection.