CAS: 106261-48-7; 4-((4-Methylpiperazin-1-yl)Methyl)Benzoic Acid

相似化合物

106261-49-8 479353-63-4 125743-63-7

上下游产品

CAS号109-01-3 N-甲基哌嗪 | CAS号619-66-9 对醛基苯甲酸 | CAS号1642-81-5 4-氯甲基苯甲酸 | CAS号728936-43-4 4-(4-methylpipe... | CAS号314268-40-1 4-[(4-甲基-1-哌嗪基)... | CAS号1571-08-0 对甲酰基苯甲酸甲酯 | CAS号790299-79-5 马赛替尼 | CAS号314268-40-1 4-[(4-甲基-1-哌嗪基)... | CAS号152459-95-5 伊马替尼 | CAS号148077-69-4 4-(4-甲基哌嗪甲基)苯甲酰氯

4-[(4-甲基哌嗪-1-基)甲基]苯甲酸甲酯置于盐酸,甲醇,水体系中,化学反应 5.0H,反应生成4-(4-甲基-1-哌嗪基甲基)苯甲酸
参考文献: Fluoro-Substituted Compounds As Kinase Inhibitors And Methods Of Use Thereof[fr] Composés à Substitution Fluoro En Tant Qu'Inhibiteurs De Kinase Et Leurs Méthodes D'Utilisation
标题: Fluoro-Substituted Compounds As Kinase Inhibitors And Methods Of Use Thereof[fr] Composés à Substitution Fluoro En Tant Qu'Inhibiteurs De Kinase Et Leurs Méthodes D'Utilisation
摘要:本发明提供了具有激酶抑制活性的formula I的新化合物及其药用可接受的盐和溶剂化合物.本发明还提供了包含相同化合物的药物组合物,以及治疗和预防bcr-Abl,C-Kit或pdgf-R介导的疾病的方法,其中一个或多个激酶抑制剂被指示,包括肿瘤病,如慢性髓细胞白血病或胃肠道间质瘤.本发明还提供了制备formula I化合物的方法,包括其盐和溶剂化合物,以及包含相同化合物的药物组合物的过程.

专利信息

专利号:WO-2013035102-A1
优先权日:2011-09-05
标 题 :Processes for the preparation of imatinib base and intermediates thereof
发明人：KOMPELLA AMALA KISHAN; RACHAKONDA SREENIVAS; GAMPA VENU GOPALA KRISHNA; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD; KOMPELLA AMALA KISHAN; RACHAKONDA SREENIVAS; GAMPA VENU GOPALA KRISHNA; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
摘要:The invention relates to an improved process for the preparation of highly pure imatinib base (99.99% HPLC purity) of formula (I) and the pharmaceutically acceptable acid addition salts thereof. This invention also relates to processes for the preparation of the intermediates in the synthesis of imatinib base.

专利号:US-2023065387-A1
优先权日:2019-10-14
标题:Synthesis of tyrosine kinase inhibitors

专利号:US-2011097268-A1
优先权日:2006-08-23
标 题 :Radiohaloimatinibs and methods of their synthesis and use in pet imaging of cancers
发明人：BORNMANN WILLIAM; ALAUDDIN MIAN; GELOVANI JURI; GHOSH PRADIP; GUO LIWEI; HAN DONGMEI; MAXWELL DAVID; MUKHOPADHYAY UDAY; PENG ZHENGHONG; SHAVRIN ALEKSANDR; YING YUNMING
权利人:UNIV TEXAS
摘要:We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells.

专利号:AU-2008214679-A1
优先权日:2007-02-13
标题 :Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors

专利号:US-2010121063-A1
优先权日:2007-02-13
标题:Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors

专利号:CA-2970628-A1
优先权日:2007-02-13
标题:Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors