CAS: 10458-14-7; 2-Isopropyl-5-Methylcyclohexanone

该化合物是一个圆形单体单体-1-one, 以其独特的微粒芳香为特征,通常与薄荷和其他薄荷油相关,具有C10H18O的分子分子分子配方,具有源自月经的双环结构.该化合物一般在室内温度下是无色的,可粉黄黄色液体,在有机溶剂中溶解,但水溶解较少. p-Menthan-3-one 展示了一个沸点,允许其用于各种用途,包括调味,香味和有机合成中的潜在中间体.其化学特性包括氯酮的再活动,例如正在经历核分裂性添加反应.此外, p-menthan-3-one 已经研究其潜在的生物活动,包括抗微细菌和抗炎炎特性.由于它的香味和口味特征,它在食品和化妆品工业中广泛使用.安全数据表明,尽管一般认为在低浓度中处理时应加以安全处理.

结构式图片

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欧盟法规

ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

    (2-Isopropyl-5-Methylcyclohexyloxy)Trimethylsilane置于1,4-Dichloro-1,4-Diazoniabicyclo[2,2,2]octane Bis-Chloride体系中,用 水 用作溶剂,化学反应 0.58H,以86%的收率获得5-甲基-2-异丙基环己酮
    参考文献:Synthesis Of Amino Substituted Pyrazoles
    标题:Synthesis Of Amino Substituted Pyrazoles
    摘要:报告了通过水合肼对烯酮 N,S-乙醛或混合 N,N-氨基水合物的作用,高效,方便地合成在 C-3 和 C-5 位上带有芳基和杂芳基氨基取代基的取代吡唑的方法.
    Doi:10.3184/030823407X209723

    专利信息


    专利号:WO-2004011474-A1
    优先权日:2002-07-31
    标题:Universal support media for synthesis of oligomeric compounds
    发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
    权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
    摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

    专利号:US-6653468-B1
    优先权日:2002-07-31
    标 题 :Universal support media for synthesis of oligomeric compounds
    发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH
    权利人:ISIS PHARMACEUTICALS INC
    摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

    专利号:US-7358382-B2
    优先权日:2001-08-03
    标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production
    发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
    权利人:BAYER SCHERING PHARMA AG
    摘要:The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothilone derivatives.

    专利号:US-7368568-B2
    优先权日:2001-08-03
    标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use
    发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
    权利人:BAYER SCHERING PHARMA AG
    摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroarnides for the synthesis of edothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

    专利号:US-6933385-B2
    优先权日:2001-08-03
    标题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use
    发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
    权利人:SCHERING AG
    摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

    专利号:US-2024082118-A1
    优先权日:2021-05-19
    标 题:Topical compositions and methods of preparing the same
    发明人:ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION
    权利人:LANDA LABS 2012 LTD
    摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.
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    主要参考文献

    [参考文献]: Mauricio G Zaia, Et Al. Anti-Inflammatory Properties Of Menthol And Menthone In Schistosoma Mansoni Infection. Front Pharmacol. 2016 Jun 17;7:170.
    [参考文献]: Shima Toghiani, Et Al. The Effects Of Vitamin C And Menthone On Acyclovir Induced Dna Damage In Rat Spermatozoa: An Experimental Study. Int J Reprod Biomed. 2018 Nov;16(11):703-710.
    [参考文献]: Egle Bylaite, Et Al. Effect Of Xanthan On Flavor Release From Thickened Viscous Food Model Systems. J Agric Food Chem. 2005 May 4;53(9):3577-83.
    [参考文献]: J S Dambolena, Et Al. Inhibitory Effect Of Cyclic Terpenes (Limonene, Menthol, Menthone And Thymol) On Fusarium Verticillioides Mrc 826 Growth And Fumonisin B1 Biosynthesis. Toxicon. 2008 Jan;51(1):37-44.
    [参考文献]: Laure Saint-Lary, Et Al. Volatile Compounds Of Viola Odorata Absolutes: Identification Of Odorant Active Markers To Distinguish Plants Originating From France And Egypt. Chem Biodivers. 2014 Jun;11(6):843-60.

    合成参考文献


    参考文献:10.1186/1471-2164-11-111
    摘要:Qin Q, McCallum EJ, Kaas Q, Suda J, Saska I, Craik DJ, Mylne JS. Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis. BMC Genomics. 2010 Feb 16;11():111.
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