CAS: 101-49-5; 2-Benzyl-1,3-Dioxolane

该化合物是一种有机化合物,其特点是二氧环结构,由五人环组成,内含两个氧原子和三个碳原子;二氧烷2位置时存在一个苯基组(附属于一个甲基桥梁的苯基组),这助长了其芳香特性;该化合物一般是无色的,可粉色黄色液体,有甜美的香味;在水中可中度溶解,有机溶剂中可溶性更强,反映了二氧烷混合物和三碳原子组的双重性质;2-苯基-1,3-二氧酚烷经常用于有机合成,并用作各种药品和精美化学品的生产中间体;其活性可归因于二氧烷环的存在,在一定条件下可发生环状开关反应,使其在合成化学中成为有价值的建筑块;安全数据表明,应谨慎处理该物质,因为它在接触时可能构成健康风险.

结构式图片

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4412-50-4 898759-51-8 898759-42-7

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上下游产品

CAS号122-78-1 2-苯基乙醛 | CAS号107-21-1 乙二醇 | CAS号24699-49-8 2-Benzyl-1,3-ox... | CAS号536-74-3 苯乙炔 | CAS号101-48-4 苯乙醛二甲基缩醛 | CAS号98-80-6 苯硼酸 | CAS号292638-84-7 phenylene-ethylene | CAS号781-35-1 1,1-二苯基丙酮 | CAS号19693-75-5 2-甲氧基-1,3-二氧戊环 | CAS号23450-31-9 4-苄基苯甲腈 | CAS号103-29-7 1, 2-二苯乙烷 | CAS号108-88-3 甲苯 | CAS号10199-69-6 1-methyl-4-phen... | CAS号101-48-4 苯乙醛二甲基缩醛 | CAS号31593-52-9 1,3-Dithiane,2-... | CAS号60-12-8 苯乙醇 | CAS号74121-91-8 2-(2-phenyletho... | CAS号943-59-9 2-chloroethyl 2...

合成工艺路线路线简述

  • 107-21-1 + 18065-04-8 = 101-49-5 + 90-05-1
    反应条件:1.1 Catalysts: Trifluoromethanesulfonic Acid Solvents: 1,4-Dioxane; 2 H,140 °C
    标题:Aromatic Monomers By In Situ Conversion Of Reactive Intermediates In The Acid-Catalyzed Depolymerization Of Lignin
    作者:Deuss,Peter J.; Scott,Martin; Tran,Fanny; Westwood,Nicholas J.; De Vries,Johannes G.; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2015 卷标:137(23) 页码:7456-7467
📜1,1-二苯基丙酮置于三甲基氯硅烷体系中,用80%的收率获得苯乙醛-乙二醇缩醛
参考文献:Arnold,Donald R.; Lamont,Laurie J.,Canadian Journal Of Chemistry,1989,Vol. 67,P. 2119-2127
标题:Arnold,Donald R.; Lamont,Laurie J.,Canadian Journal Of Chemistry,1989,Vol. 67,P. 2119-2127

专利信息


专利号:US-5191087-A
优先权日:1991-07-24
标 题 :Process for the synthesis of 1,4-disubstituted pyrazoles
发明人:ALCARAZ JEAN-MARIE; LECACHEUR MARYSE; ROBIN YVES
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The present invention relates to a process for the synthesis of 1,4-disubstituted pyrazoles. A monosubstituted hydrazine is reacted with the product of reaction of an acetal with an N-substituted halomethyliminium salt, preferably N,N-dimethylchloromethyliminium chloride. n The 1,4-disubstituted pyrazoles are, in particular, important intermediates in the synthesis of herbicides or drugs.

专利号:US-7179919-B2
优先权日:2004-03-18
标 题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人:SONG JINHUA J; TAN ZHULIN; YEE NATHAN K; SENANAYAKE CHRIS HUGH; XU JINGHUA; GALLOU FABRICE
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , and R 5 are as described herein.

专利号:US-7507843-B2
优先权日:2003-10-16
标题:Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人:SONG JINHUA J; TAN ZHULIN; XU JINGHUA; YEE NATHAN K; SENANAYAKE CHRIS H
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of compounds of Formula X wherein: R1 is an aryl or heteroaryl group, each optionally independently substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, C1-C5 alkoxy, C2-C5 alkenyloxy, C2-C5 alkynyloxy, aryloxy, C1-C5 alkanoyloxy, C1-C5 alkanoyl, aroyl, trifluoromethyl, trifluoromethoxy, or C1-C5 alkylthio, wherein each substituent group of R1 is optionally independently substituted with one to three substituent groups selected from methyl, methoxy, fluoro, chloro, hydroxy, oxo, cyano, or amino; and R2 and R3 are each independently hydrogen or C1-C5 alkyl, or R2 and R3 together with the carbon atom they are commonly attached to form a C3-C8 spiro cycloalkyl ring.

专利号:EP-2280974-B1
优先权日:2008-04-30
标题:Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人:REEVES JONATHAN TIMOTHY; SONG JINHUA J; TAN ZHULIN
权利人:BOEHRINGER INGELHEIM INT; BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人:XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-7256300-B2
优先权日:2004-03-30
标 题:Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人:LEE THOMAS WAI-HO; PROUDFOOT JOHN ROBERT
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (X) or Formula (X′) n nwherein R 1 , R 2 , and R 3 are as defined herein, the process comprising:n (a) reacting the starting material of formula A with a chiral sulfoxide anion source in a suitable solvent to prepare a compound of formula C or C′; (b) reducing the sulfoxide of formula C or C′ in a suitable solvent to obtain the compound of formula D or D′; and (c) cyclizing the compound of formula D or D′ in a suitable solvent to form the epoxide compound of Formula (X) or Formula (X′),n nor a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

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合成参考文献


摘要:Food and Cosmetics Toxicology., 14(827), 1976
摘要:Milata, V.; Rádl, S.; Voltrová, S., Science of Synthesis, (2008) 32, 688.
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