CAS: 923-26-2; 2-Hydroxypropyl Methacrylate

该化合物是一种有机化合物,其特征是甲基丙烯酸作用组和一个氢氧基组;一种无色的黄黄色液体,具有独特的气味,可溶于水和有机溶剂;HPMA因其具有聚合能力而闻名,使其在生产各种聚合物和共聚物方面具有价值;氢氧基丙烯酸酯组的存在增强了其再活性,允许其在聚合物应用中进一步发挥功能和交叉联系;该化合物因其极好的粘合剂,涂层和密封剂的特性和耐久性,通常用于其配制;此外,HPMA可被用于生物医学应用,例如药物输送系统和组织工程,因其生物兼容性和形成体能,因此对各种聚合物和共聚物具有价值;安全考虑包括以适当的保护措施处理该化合物,因为它可能对皮肤和眼睛具有刺激性;

英文名称2-Hydroxypropyl Methacrylate
中文名称2-羟丙基异丁烯酸酯
IUPAC名称2-hydroxypropyl 2-methylprop-2-enoate
其它别名methacrylic acid, 2-hydroxypropyl ester
CAS编号923-26-2
MFCD编号:MFCD00004536
EINECS号:213-090-3
分子式:C7H12O3分子量:144.17
产品CID: 1961084
产品分类化学试剂 → 有机试剂 → 酯类

相似结构搜索
InChIKey: VHSHLMUCYSAUQU-UHFFFAOYNA-N
InChI=1/C7H12O3/c1-5(2)7(9)10-4-6(3)8/h6,8H,1,4H2,2-3H3
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数4.0

物理性质

熔点40 °C
沸点240 °C
闪点101 °C
密度1.03
pKa:13.90±0.20(预测)
PSA:46.53
LogP:0.4865
折射率1.447-1.449
蒸汽压0.105 mmHg at 25 °C
溶解性less than 1 mg/mL at 73° F (NTP, 1992)
敏感性常温常压下稳定，避免强氧化剂接触
外观形态透明无色液体
储存条件冰箱 (+4°C)
性质描述熔点40°C,沸点240°C,相对密度1.03,折光系数 1.447-1.449

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别严重眼刺激类别2
皮肤致敏类别1
警示词Warning(警告)
危险描述H319 |造成严重眼刺激.
H317 |可能引起皮肤过敏反应.
防范说明P264-P280-P305+P351+P338-P337+P313P-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
危险品标志Xi
安全声明37/39-26-24/25
危险类别码43-36

欧盟法规

统一分类与标签ECHA物质工作场所安全标识要求ECHA物质C&L通报REACH预注册废弃物危险特性清单

上下游产品

CAS号79-41-4 甲基丙烯酸 | CAS号75-56-9 环氧丙烷 | CAS号57-55-6 丙二醇 | CAS号80-62-6 甲基丙烯酸甲酯 | CAS号7559-82-2 1,3-丙二醇二甲基丙烯酸酯

合成工艺路线路线简述

合成目标产物 2-Hydroxypropyl Methacrylate 主要起始原料 Propylene Glycol And Methacrylic Anhydride
760-93-0 + 78-96-6 = 923-26-2
反应条件:1.1 Solvents: Diethyl Ether,Dichloromethane; 2 H,Rt
标题:Hyperbranched Polymer Hydrogels With Large Stimuli-Responsive Changes In Storage Moduli And Peroxide-Induced Healing
作者:Chimala,Prathyusha; Perera,M. Mario; Wade,Aissatou; Mckenzie,Tucker; Allor,Joshua; Et Al
参考文献:Polymer Chemistry 日期:2021 卷标:12(30) 页码:4384-4393]

923-26-2 = 923-26-2
反应条件:1.1 Reagents: Triethylamine,2-Bromoisobutyryl Bromide Catalysts: 4-(Dimethylamino)Pyridine; 1 H,10 °C; 24 H,10 °C -> 50 °C1.2 Reagents: Sodium Ascorbate Catalysts: Peroxidase Solvents: Water; 8 H,Ph 8,60 °C
标题:Preparation,Structure,And Properties Of Silk Fabric Grafted With 2-Hydroxypropyl Methacrylate Using The Hrp Biocatalyzed Atrp Method
作者:Yang,Jinqiu; Lu,Shenzhou; Xing,Tieling; Chen,Guoqiang
参考文献:Polymers (Basel 日期:2018 卷标:10(5)]

= 923-26-2 [标题:Reaction Conditions
标题:Self-Assembling Peptide-Polymer Nano-Objects Via Polymerization-Induced Self-Assembly
作者:Dao,T. P. Tuyen; Vezenkov,Lubomir; Subra,Gilles; Amblard,Muriel; In,Martin; Et Al
参考文献:Macromolecules (Washington 日期:2020 卷标:53(16) 页码:7034-7043]

= 923-26-2 [标题:Reaction Conditions
标题:A Process For The Preparation Of A Novel Modified Fibrin-Fibrillar Protein Composite Sheet
参考文献:India]

= 923-26-2 [标题:Reaction Conditions
标题:Esterification
参考文献:Japan]

= 923-26-2 [标题:Reaction Conditions
标题:Manufacture Of β-Hydroxyalkyl Acrylate Or Methacrylate
参考文献:Japan]

= 923-26-2 [标题:Reaction Conditions
标题:2-Hydroxyalkyl Acrylates And Methacrylates
参考文献:Federal Republic Of Germany]

= 923-26-2 [标题:Reaction Conditions
标题:β-Hydroxyalkyl Esters Of α,β-Unsaturated Fatty Acids
参考文献:Japan]

760-93-0 + 57-55-6 = 923-26-2
反应条件:1.1 Reagents: 4-(Dimethylamino)Pyridine Catalysts: Pyridine Solvents: Tetrahydrofuran; 30 Min,23 °C; 23 °C -> 5 °C1.2 30 Min; 1 H,23 °C
标题:Compound For Resin And Resist Composition,And Manufacturing Method Of Resist Pattern With Good Line Edge Roughness
参考文献:Japan]

57-55-6 = 923-26-2
反应条件:1.1 Solvents: 2-Methyl-2-Butanol; 120 H,50 °C
标题:Hydroxy Functional Acrylate And Methacrylate Monomers Prepared Via Lipase-Catalyzed Transacylation Reactions
作者:Popescu,Dragos; Hoogenboom,Richard; Keul,Helmut; Moeller,Martin
参考文献:Journal Of Molecular Catalysis B: Enzymatic 日期:2009 卷标:62(1) 页码:81-90]

= 923-26-2 [标题:Reaction Conditions
标题:Hydroxypropyl Methacrylate And Polymers Based On It
作者:Aliev,V. S.; Asadov,Z. G.; Yusubov,A. Yu.; Agazade,A. D.; Allakhverdiev,D. I.; Et Al
参考文献:Azerbaidzhanskii Khimicheskii Zhurnal 日期:1986 卷标:(2) 页码:55-60]

= 923-26-2
反应条件:1.1 Catalysts: Pyridine
标题:Preparation Of β-Hydroxyisopropyl Methacrylate And Study Of Its Properties
作者:Obami,Alfons; Mekhtiev,S. I.; Shikhalizade,P. D.; Safarov,Yu. D.
参考文献:Azerbaidzhanskii Khimicheskii Zhurnal 日期:1984 卷标:(4) 页码:21-4]

= 923-26-2 [标题:Reaction Conditions
标题:Soft Caps Containing Polymers Of Vinyl Esters And Polyethers,Their Use And Production
参考文献:Germany]

= 923-26-2 [标题:Reaction Conditions
标题:β-Hydroxyalkyl Acrylates And Metacrylates
参考文献:Japan]

= 923-26-2 [标题:Reaction Conditions
标题:2-Hydroxyalkylacrylates Or 2-Hydroxy-Alkylmethacrylates
参考文献:Japan]

= 923-26-2 [标题:Reaction Conditions
标题:Synthesis Of Monoacrylic Acid Esters Of Alkylene Glycols
作者:Gololobova,A. A.; Salakhetdinova,Z. S.; Sineokov,A. P.
参考文献:Osnovn. Organ. Sintez I Neftekhimiya 日期:1976 卷标:(6) 页码:47-52]

= 923-26-2 [标题:Reaction Conditions
标题:Separation Of 2-Hydroxypropyl Methacrylate From Synthesis Products
作者:Stepanov,E. G.; Saraev,B. A.; Podgornova,V. A.; Ustavshchikov,B. F.
参考文献:Prom-St' Sintetich. Kauchuka. Nauch.-Tekhn. Sb. 日期:1975 卷标:(6) 页码:5-7]

= 923-26-2 [标题:Reaction Conditions
标题:Unsaturated β-Hydroxyalkyl Carboxylates
参考文献:United States]

= 923-26-2 [标题:Reaction Conditions
标题:β-Hydroxyalkyl Esters Of Olefinically Unsaturated Acids And Polymers And Coatings Therefrom
参考文献:South Africa]

= 923-26-2 [标题:Reaction Conditions
标题:Acrylic Acid And Methacrylic Acid Hydroxyalkyl Esters
参考文献:United Kingdom

📜1.2-α-Methacrylideno-Propandiol置于phthalic Acid Butyl Ester,氧气体系中,化学反应生成 2-羟丙基异丁烯酸酯
参考文献:Autoxidation Of 2-Alkenyldioxolanes And 2-Alkenyl-1,3-Dioxanes
标题:Autoxidation Of 2-Alkenyldioxolanes And 2-Alkenyl-1,3-Dioxanes
摘要:
DOI:10.1021/jo01025A007