2-溴-1-(2,4-二甲基苯基)乙酮置于异丙苯,四丁基溴化铵体系中,化学反应 66.0H,以41%的收率获得产物2,4-二甲基苯乙酮 参考文献:Trapping The Single Electron Transfer Intermediate In An Sn2 Reaction 标题:Trapping The Single Electron Transfer Intermediate In An Sn2 Reaction 摘要: DOI:10.1021/ja00116A053
专利号:US-2022145179-A1 优先权日:2020-11-12 标题 :Synthesis of aryl 1-(methoxymethyl) vinyl ketones and their use as inhibitors of mild steel corrosion 发明人:MAZUMDER MOHAMMAD ABU JAFAR; ALI SHAIKH ASROF; ODEWUNMI NURUDEEN; ALHARBI BADER; ALJEABAN NORAH; CHEN TAO; BALHARTH SALEM 权利人:SAUDI ARABIAN OIL CO; UNIV KING FAHD PET & MINERALS 摘要:Methods for preparing alkenylphenone corrosion inhibiting compositions may include providing an arylacetone and reacting the arylacetone with formaldehyde in the presence of a strong base catalyst. Corrosion inhibiting compositions may include an alkenylphenone, which may be prepared by a method including providing an arylacetone and reacting the arylacetone with formaldehyde in the presence of a strong base catalyst. Methods of inhibiting corrosion of a steel surface of an oilfield equipment component may include contacting the steel surface with an aqueous solution comprising a corrosion inhibitor. The corrosion inhibitor may include a composition containing an alkenylphenone prepared by reacting an arylacetone with formaldehyde in the presence of a strong base catalyst.
专利号:WO-2022104049-A1 优先权日:2020-11-12 标题 :Synthesis of aryl 1-(methoxymethyl) vinyl ketones and their use as inhibitors of mild steel corrosion
专利号:US-9163020-B2 优先权日:2013-07-17 标 题 :Azaindole compounds, synthesis thereof, and methods of using the same 发明人:SHIRUDE PRAVIN S; NAIK MARUTI N; SHINDE VIKAS NARAYAN; PEER MOHAMED SHAHUL HAMEED; CHATTERJI MONALISA; SHINDIL RADHA K 权利人:GLOBAL ALLIANCE FOR TB DRUG DEV; ASTRAZENECA AB; FOUNDATION FOR NEGLECTED DISEASE RES 摘要:The invention provides compounds of formula (I) and methods of treating a Mycobacterium infection or tuberculosis, or inhibiting DprE1 with the same.
专利号:US-8513241-B2 优先权日:2008-03-28 标题 :3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them 发明人:CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA 权利人:CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA; NERVIANO MEDICAL SCIENCES SRL 摘要:Compounds which are 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.
专利号:CA-2918487-A1 优先权日:2013-07-17 标 题 :Azaindole compounds, synthesis thereof, and methods of using the same
专利号:US-2015025087-A1 优先权日:2013-07-17 标题 :Azaindole compounds, synthesis thereof, and methods of using the same
[参考文献]: Masahiko Nakamura, Et Al. Discovery Of Tetrahydrotetramethylnaphthalene Analogs As Adult T-Cell Leukemia Cell-Selective Proliferation Inhibitors In A Small Chemical Library Constructed Based On Multi-Template Hypothesis. Bioorg Med Chem. 2009 Jul 1;17(13):4740-6.
合成参考文献
摘要:Zysman-Colman, E., Science of Synthesis, (2010) 45, 189.