CAS: 80-65-9; 3-Aminooxazolidin-2-One

该化合物是一个环环环有机化合物,其核心为氧化氮,在3点有氨基替代成分,这种结构在合成应用中具有多功能性,特别是作为制药和农用化学的一个构件,它的活性氨基组可以使粪便衍生,而氧化氮丁酮脚架则有助于稳定性和生物活性.该化合物因其在药用化学中的作用而受到重视,因为它是抗生素,酶抑制剂和其他生物活性分子的前体.其定义明确的再活性特征和与各种合成条件的兼容性使其在有机合成中成为有用的中间体.建议进行适当的处理和储存,因为其潜在的敏感性.

英文名称3-Aminooxazolidin-2-One
中文名称3-氨基噁唑烷-2-酮
IUPAC名称3-aminooxazolidin-2-one
其它别名3-Aminooxazolidin-2-Id-4-One; 3-Amino Oxazolidinone; 3-Amino-2-Oxazolidinone; Unii-Vj7He86A15; Inchi=1/c3H6N2O2/c4-5-1-2-7-3(5)6/h
CAS编号80-65-9
MFCD编号:MFCD00020871
EINECS号:201-299-2
FDA UNII编号:VJ7HE86A15
分子式:C3H6N2O2
分子量:102.09
产品CID: 1801658
产品分类分析化学 → 标准品 → 生命科学标准品

相似结构搜索
InChIKey: KYCJNIUHWNJNCT-UHFFFAOYSA-N
InChI=1S/C3H6N2O2/c4-5-1-2-7-3(5)6/h1-2,4H2…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数0.0

物理性质

熔点65-67 °C
沸点167.2±23.0 °C at 760 mmHg
闪点54.9±22.6 °C
密度1.4±0.1 g/cm3
pKa:3.24±0.20(预测)
PSA:55.56
LogP:-1.75
折射率1.518
蒸汽压1.7±0.3 mmHg at 25°C
溶解性Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
外观形态白色至类白色固体
储存条件置于阴暗处,密封干燥,2-8°C
产品应用二氟丙二酸二乙酯(80-65-9)由β-羟乙基脲进行亚硝化,环合,还原反应得到.是一类抗菌药呋喃唑酮的中间体.
性质描述二氟丙二酸二乙酯(80-65-9)熔点:65-67 °C 储存条件:0-6°C .

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P271-P280-P302+P352-P305+P351+P338
UN编号NONH for all modes of transport
危险品标志Xi
安全声明26-36/37
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

合成目标产物 3-Amino-2-Oxazolidinone 主要起始原料 2-Hydroxyethylhydrazine And Diethyl Carbonate
109-84-2 = 80-65-9
反应条件:1.1 Reagents: Sodium Ethoxide; 4 H,Reflux
标题:Design,Synthesis,And Biological Evaluation Of 3-Amino-2-Oxazolidinone Derivatives As Potent Quorum-Sensing Inhibitors Of Pseudomonas Aeruginosa Pao1
作者:Jiang,Kai; Yan,Xinlin; Yu,Jiahao; Xiao,Zijian; Wu,Hao; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:2020 卷标:194]

109-84-2 = 80-65-9
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol; 3 H,70 °C
标题:One-Pot Synthesis Of Pentasubstituted Pyridines Following The Gold(I)-Catalyzed Aza-Enyne Metathesis/6π-Electrocyclization-Aromatization Sequence
作者:Kosuge,Shuto; Araki,Yusuke; Tsuge,Kiyoshi; Sugimoto,Kenji; Matsuya,Yuji
参考文献:Journal Of Organic Chemistry 日期:2023 卷标:88(11) 页码:6973-6986]

109-84-2 = 80-65-9
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol; 3 H,70 °C
标题:3-Aminooxazolidinone Ahl Analogs As Hydrolytically-Stable Quorum Sensing Agonists In Gram-Negative Bacteria
作者:Guo,Min; Zheng,Yue; Starks,Rusty; Opoku-Temeng,Clement; Ma,Xiaochu; Et Al
参考文献:Medchemcomm 日期:2015 卷标:6(6) 页码:1086-1092

呋喃唑酮置于spring Onion Leaf/root Bulb体系中,化学反应 12.0H,反应生成 3-氨基噁唑烷-2-酮
参考文献:硝基呋喃污染土壤中生长的葱中的硝基呋喃抗生素对植物的吸收和代谢.
标题:硝基呋喃污染土壤中生长的葱中的硝基呋喃抗生素对植物的吸收和代谢.
摘要:由于诱变和致癌的硝基呋喃向水生和土壤环境的排放而引起的环境污染是引起公众健康的一个新问题,因为它具有产生抗药性微生物和被粮食作物吸收的潜力.使用液相色谱-串联质谱分析并以大葱(葱木荒木)作为植物模型,我们在此研究中研究了植物在污染环境中对硝基呋喃的吸收和积累.我们的研究首次揭示了粮食作物可食用部分中呋喃的高吸收和积累速率.此外,结果表明植物体内吸收的硝基呋喃的高效植物新陈代谢,导致形成具有遗传毒性的肼代谢物.
DOI:10.1021/acs.Jafc.7B01050

海关参考信息

2912110000-甲醛
2915110000-甲酸
2922110001-单乙醇胺
2909199090-其他醚及其衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:CN-117801027-A
优先权日:2023-07-03
标题 :Synthesis of cobalt compound with spiral structure and application of cobalt compound in electrochemical detection

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:CN-117801027-B
优先权日:2023-07-03
标题:Synthesis of cobalt compound with spiral structure and application of cobalt compound in electrochemical detection

专利号:CN-113502490-A
优先权日:2021-08-16
标题 :A kind of electrochemical oxidation reaction method for the synthesis of tetrazene compounds