CAS: 7311-63-9; 5-Bromothiophene-2-Carboxylic Acid

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CAS号4701-17-1 5-溴噻吩-2-甲醛 | CAS号527-72-0 2-噻吩甲酸 | CAS号3141-27-3 2,5-二溴噻吩 | CAS号124-38-9 二氧化碳 | CAS号1003-09-4 2-溴噻吩 | CAS号5370-25-2 2-乙酰基-5-溴噻吩 | CAS号5751-83-7 5-溴噻吩-2-甲酸乙酯 | CAS号74-96-4 溴乙烷 | CAS号60-29-7 乙醚 | CAS号60141-31-3 5-(3-噻吩基)噻吩-2-羧酸 | CAS号395664-59-2 5-溴-4-氟-2-噻吩甲酸甲酯 | CAS号4066-41-5 5-乙酰基噻吩-2-甲酸 | CAS号4701-17-1 5-溴噻吩-2-甲醛 | CAS号38239-32-6 5-溴-4-硝基噻吩-2-羧酸甲酯 | CAS号20873-58-9 5-(甲基硫代)噻吩-2-羧酸 | CAS号79387-71-6 5-溴-2-噻吩甲醇 | CAS号98027-27-1 5-溴噻吩-2-甲酰肼 | CAS号89499-43-4 4-氨基噻吩-2-甲酸甲酯 | CAS号930-69-8 苯硫酚钠

2-噻吩甲酸置于n-溴代丁二酰亚胺(Nbs)体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 12.0H,以35%的收率获得产物5-溴-2-羧基噻吩
参考文献:基于炔丙胺的hdac抑制剂的结构-活性关系
标题:基于炔丙胺的hdac抑制剂的结构-活性关系
摘要:由于组蛋白脱乙酰基酶(hdacs)在癌症的治疗中起着重要的作用,其选择性抑制已成为各种研究的主题.这些不断的研究引起了广泛的hdac抑制剂和选择性hdac抑制剂的收集,其中包括美国食品和药物管理局(fda)批准的各种代表.在先前的研究中,提出了一类基于炔烃的hdac抑制剂.我们在两个先前被忽略的区域中修改了该支架,并比较了它们对hdac1,Hdac6和hdac8的细胞毒性和亲和力.我们能够证明r配置的炔丙基胺有助于提高对hdac6的选择性.对可用的hdac晶体结构进行了对接研究,以合理化所观测到的化合物的选择性.噻吩衍生物取代芳族部分导致高亲和力和低细胞毒性,表明药物耐受性提高.
DOI:10.1002/cmdc.201700550

专利信息

专利号:US-2010317848-A1
优先权日:2006-12-31
标题:Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments

专利号:US-2013005962-A1
优先权日:2006-12-31
标题 :Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments

专利号:KR-20090097208-A
优先权日:2006-12-31
标 题:Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments

专利号:US-11795162-B2
优先权日:2017-08-18
标题:Modulators of the estrogen-related receptor
发明人：BURRIS THOMAS; WALKER JOHN K; HAMPTON CARISSA S; HAYNES KEITH MCCORMICK; GRIFFETT KRISTINE; BILLON CYRIELLE; SITAULA SADICHHA
权利人:UNIV SAINT LOUIS
摘要:In one aspect, the present disclosure describes new estrogen receptor-related orphan receptor (EER) inverse agonist compounds. Also described are pharmaceutical formulations, methods of synthesis and uses thereof.

专利号:US-9318716-B1
优先权日:2011-10-18
标题:Process for making electronically active functionalized silsequioxane nanostructures of controlled morphology through covalent synthesis
发明人：RATHNAYAKE HEMALI
权利人:RATHNAYAKE HEMALI; WESTERN KENTUCKY UNIVERSITY RES FOUNDATION
摘要:Disclosed is a composition comprising perylenediimide bridged dimethylethoxysilane. Disclosed also is an electronically active nanostructure comprising perylenediimide bridged dimethylethoxysilane. Disclosed also is a process for fabricating a photovoltaic device comprising depositing an electronically active nanostructure, the nanostructure made by hydrolysis and condensation of perylenediimide bridged dimethylethoxysilane, onto a substrate.

专利号:NZ-578715-A
优先权日:2006-12-31
标 题 :Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments