CAS: 641-38-3; Alternariol

上下游产品

CAS号7149-90-8 2,4-二甲氧基-6-甲基苯甲醛 | CAS号131035-44-4 2,4-dimethoxy-6... | CAS号131035-47-7 3-(2,4-dimethox... | CAS号131035-45-5 ethyl 2,4-dimet... | CAS号131035-48-8 methyl 3-(2,4-d... | CAS号23452-05-3 交链孢酚单甲醚 | CAS号23452-05-3 交链孢酚单甲醚 | CAS号979-92-0 S-腺苷-L-高半胱氨酸

📜3-甲氧基-5-甲基苯酚置于n-溴代丁二酰亚胺(Nbs),[ruthenium(II)(η6-1-Methyl-4-Isopropyl-Benzene)(Chloride)(μ-Chloride)]2,三溴化硼,Caesium Carbonate,三环己基膦体系中,用 N-甲基吡咯烷酮,二氯甲烷,氯仿 作为反应溶剂,化学反应 23.0H,反应生成 交链孢酚
参考文献:Alternariol,Alternariol-9-Monomethyl Ether 及其 D3-Isotopologues 的简明合成
标题:Alternariol,Alternariol-9-Monomethyl Ether 及其 D3-Isotopologues 的简明合成
摘要:Alternariol (Aoh) 和alternariol-9-Monomethyl Ether (Ame) 是链格孢真菌的两种次级代谢产物,可以在西红柿,坚果和谷物等各种食品中找到.由于它们的毒性和潜在的诱变活性,开发用于监测 Aoh 和 Ame 水平的高通量方法的需求越来越受到关注.由于天然和标记的 Aoh 和 Ame 分析标准的可用性非常有限,我们在此提出了一种新颖而简洁的合成方法,采用钌催化的邻芳基化作为关键步骤.最后,我们证明了它们在稳定同位素稀释测定 (Sida)-HPLC-Ms/ms 分析中作为内标的适用性,这是一种常用于定量食品和饲料中天然产物的技术.
DOI:10.1055/a-1698-8328

专利信息

专利号:US-2005282781-A1
优先权日:2004-06-18
标 题 :Compositions of stable bioactive metabolites of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids
发明人：GHOSAL SHIBNATH
权利人:GHOSAL SHIBNATH
摘要:An invention that adduces cogent evidence to establish that oxygenated dibenzo-α-pyrones (DBPs and their conjugates), the major bioactives of shilajit (Ayurvedic vitalizer), have their origin, at least partly, in EPA and DHA. Earlier research has shown that, in mammals, C-20 PUFAs are metabolized by oxygenases and other enzymes to produce short-lived prostaglandins, leukotrienes and thromboxanes that bind to specific G-protein-coupled receptors and signal cellular responses, e.g., inflammation, vasodilation, blood pressure, pain etc. But never before it was suggested/shown that C 20:5n-3 (and C 22:6 n-3 ) PUFAs, e.g., EPA (and DHA), are transformed into stable aromatic metabolites, DBPs, which elicit a large array of bioactivities in the producer organisms and also control the synthesis and metabolism of arachidonate-derived prostaglandins. The major beneficial effects attributed to EPA and DHA are now found to be largely contributed by DBPs and their aminoacyl conjugates and the dibenzo-α-pyrone-chromoproteins (DCPs). Because of the highly unstable nature of EPA and DHA, when administered, they are metabolized into a large array of uncontrolled products, several of which are systemically undesirable. By contrast, DBPs, because of their stability, perform the biological response modifier (BRM) functions in a directed and sustained way. Many of the biological effects of DBPs described in this invention, were earlier attributed to EPA and DHA,—the precursors of DBPs.

专利号:CN-111202064-B
优先权日:2020-02-28
标 题:Application of honokiol in inhibiting the synthesis of mycotoxins by Alternaria

专利号:CN-115812776-B
优先权日:2022-11-18
标题:Application of Perillaldehyde in Inhibiting the Synthesis of Fungal Toxins

专利号:CN-118812610-A
优先权日:2024-07-01
标 题 :Synthesis method and application of 3-O- (6-O-malonyl-beta-D-glucoside) alternariol monomethyl ether

专利号:CN-115812776-A
优先权日:2022-11-18
标题 :Application of Perillaldehyde in Inhibiting Mycotoxin Synthesis