CAS: 625-48-9; 2-Nitroethanol

相似化合物

626-35-7 2002-24-6 2483-57-0

上下游产品

CAS号77791-00-5 2-Methyl-2-(2-n... | CAS号75-21-8 环氧乙烷 | CAS号624-76-0 2-碘-1-乙醇 | CAS号50-00-0 甲醛 | CAS号75-52-5 硝基甲烷 | CAS号563-70-2 溴代硝基甲烷 | CAS号78687-51-1 2-nitroethyl (2... | CAS号54509-73-8 ethene | CAS号75233-61-3 2-(2-硝基乙氧基)四氢吡喃 | CAS号3638-64-0 硝基乙烯 | CAS号3615-44-9 甘露庚酮糖 | CAS号5349-37-1 d-glucoheptulose | CAS号469-90-9 景天庚酮糖 | CAS号3638-64-0 硝基乙烯 | CAS号79-24-3 硝基乙烷 | CAS号191-24-2 苯并[g,h,i]苝 | CAS号625-45-6 甲氧基乙酸 | CAS号79-11-8 氯乙酸 | CAS号141-43-5 2-氨基乙醇

叔丁基 2-硝基乙基醚置于cerium(Iii) Chloride Sodium Iodide体系中,用 乙腈 作为反应溶剂,化学反应 32.0H,以97%的收率获得产物2-硝基乙醇
参考文献:叔丁基醚:酒精保护小组的复兴.用氯化铈(iii)/碘化钠轻松裂解
标题:叔丁基醚:酒精保护小组的复兴.用氯化铈(iii)/碘化钠轻松裂解
摘要:的叔丁氧基衍生物是最未充分利用的醇保护基团中的一个.在开发出简单易用的引入方案后,我们在这里提供了一种简单的程序,可通过在ch 3 Cn中用无水cecl 3和nai处理将其除去.该方法导致脂族和芳族叔丁基醚的成功裂解,并且与分子中存在的各种其他官能团和保护基团相容.
DOI:10.1002/adsc.200505469

专利信息

专利号:US-6028237-A
优先权日:1996-12-16
标题:Synthesis of cyclopropylacetylene
发明人：PARSONS JR RODNEY LAWRENCE
权利人:DU PONT PHARM CO
摘要:The present invention relates generally to novel methods for the synthesis of cyclopropylacetylene which is a reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one which is a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

专利号:US-6998484-B2
优先权日:2000-10-04
标 题:Synthesis of purine locked nucleic acid analogues
发明人：KOCH TROELS; JENSEN FLEMMING REISSIG
权利人:SANTARIS PHARMA AS
摘要:The present invention relates to a new method for the synthesis of purine LNA (Locked Nucleic Acid) analogues which provides a higher overall yield. The method comprising a regioselective 9-N purine glycosylation reaction followed by a one-pot nucleophilic aromatic substitution reaction of the 6-substituent in the purine ring and simultaneous nucleophile-induced intramolecular ring closure of the C-branched carbohydrate to form novel purine LNA analogues. The novel strategy is illustrated by the synthesis of the novel compound (1S,3R,4R,7S)-7-benzyloxy-1-methanesulfonylmethyl-3-(guanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane which is easily converted into (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-((2-N-isobutyrylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane after isobutyryl protection of the 2-amino purine group and subsequent substitution of 1-methanesulfonyl with benzoate, debenzoylation and debenzylation.

专利号:WO-9804535-A1
优先权日:1996-07-26
标 题 :A practical synthesis of benzoxazinones useful as hiv reverse transcriptase inhibitors
发明人：PIERCE MICHAEL ERNEST; RADESCA LILIAN ALICIA
权利人:DU PONT MERCK PHARMA
摘要:The present invention describes novel methods for the synthesis of benzoxazinone compounds which are useful as human immunodeficiency virus (HIV) reverse transcriptase inhibitors. The benzoxazinone of formula (VI-a) is particularly effective in the treatment of HIV.

专利号:US-12281398-B2
优先权日:2022-02-07
标题:Microfluidic process for the general electrochemical synthesis of geminal dipseudohalide or halide-pseudohalide compounds
发明人：SCHROER THORSTEN G; LECROY GREGORY E; AGUILA MIGUEL; RODRIGUEZ MAYRA P; DOWNARD TYLER J; MACLEOD BRIANNA L
权利人:US GOV AIR FORCE; US AIR FORCE
摘要:A process for the microfluidic electrochemical synthesis of geminal dipseudohalide or halide-pseudohalide compounds comprising the steps ofpumping a solution comprising a compound of Formula Iinto a microfluidic electrochemical reactor in the presence of a base, one of a halide or pseudohalide salt (MY), and a mediator;applying an electrical current through the microfluidic electrochemical reactor; andperforming oxidative addition to create a geminal dipseudohalide or halide-pseudohalide compound of the general Formula II

专利号:US-6348616-B1
优先权日:1996-07-26
标题 :Practical synthesis of benzoxazinones useful as HIV reverse transcriptase inhibitors
发明人：PIERCE MICHAEL ERNEST; RADESCA LILIAN ALICIA
摘要:The present invention describes novel methods for the synthesis of benzoxazinone compounds which are useful as human immunodeficiency virus (HIV) reverse transcriptase inhibitors. The benzoxazinone of the formula:is particularly effective in the treatment of HIV.

专利号:US-5932726-A
优先权日:1996-12-16
标 题 :Asymmetric synthesis of benzoxazinones
发明人：PIERCE MICHAEL ERNEST; CHOUDHURY ANUSUYA; PARSONS JR RODNEY LAWRENCE; RADESCA LILIAN ALICIA
权利人:DU PONT PHARM CO
摘要:The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (VI-i) ##STR1## which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.