专利号:US-2009298868-A1 优先权日:2007-11-14 标 题:Quinoline compounds as melanogenesis modifiers and uses thereof 发明人:ORLOW SETH J; KOMATSU LI NI 权利人:ORLOW SETH J; KOMATSU LI NI 摘要:A method of identification of quinoline compounds (formula I) that modify melanin synthesis (melanogenesis), and the use of such compounds and compositions thereof to control (e.g., inhibit) melanin production are disclosed. n n n n n n n n n n The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant melanogenesis activity including by way of non-limiting example, pigmentation deficiencies (albinism) and hyperpigmentation and others.
参考文献:10.1021/jm00219a002 摘要:Davidson MW, Griggs BG, Boykin DW, Wilson WD. Molecular structural effects involved in the interaction of quinolinemethanolamines with DNA. Implications for antimalarial action. J Med Chem. 1977 Sep;20(9):1117–22. doi: 10.1021/jm00219a002.