CAS: 61152-62-3; 4-(3,4-Dihydroxyphenyl)-2-Butanone

上下游产品

4-(4-hydroxy-3-methoxyphenyl)-2-butanone (E)-4-(3′,4′-dihydroxyphenyl)but-3-en-2-one 3,4-dihydroxybenzaldehyde Dehydrozingerone 4-(3',4'-dihydroxyphenyl)-2-butanol (4E,6E)-1-(3,4-dihydroxyphenyl)-7-phenylhepta-4,6-dien-3-one 3,4-Dimethoxy-(3'-hydroxybutyl)-benzol

📜姜酮置于aluminium(Iii) Iodide,N,N-二甲基甲酰胺二甲基缩醛体系中,用 乙腈 作为反应溶剂,化学反应 18.0H,以52%的收率获得产物4-(3,4-二羟基苯基)-2-丁酮
参考文献:三碘化铝和n,N-二甲基甲酰胺二甲基乙缩醛对酸不稳定的芳烷基醚的手性辅助选择性裂解.
标题:三碘化铝和n,N-二甲基甲酰胺二甲基乙缩醛对酸不稳定的芳烷基醚的手性辅助选择性裂解.
摘要:N,N-二甲基甲酰胺二甲基乙缩醛(dmf-Dma)利用三碘化铝通过相邻基团的参与选择性裂解醚.包括羧酸盐,烯丙基,叔丁基二甲基甲硅烷基(tbs)和叔丁氧羰基(boc)在内的各种酸不稳定官能团均完好无损.该方法为裂解邻苯二酚单烷基醚和从乙缩醛型保护基(如甲氧基甲基(mom),甲氧基乙氧基甲基(mem)和四氢吡喃基(thp))上化学选择性解吸酚提供了一种有效的方法.
DOI:10.1021/acs.Joc.0C00290

专利信息

专利号:US-11746364-B2
优先权日:2018-01-17
标题 :Enzymatic synthesis of kavalactones and flavokavains
发明人：PLUSKAL TOMÃ?S; Weng jing-ke
权利人:WHITEHEAD INST BIOMEDICAL RES
摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.

专利号:US-11739354-B2
优先权日:2018-01-17
标 题 :Enzymatic synthesis of kavalactones and flavokavains

专利号:US-10765748-B2
优先权日:2014-07-11
标题 :Composition and methods for tethering bioactive peptides to metal oxide surfaces
发明人：BECKER MATTHEW; TANG WEN
权利人:BECKER MATTHEW; TANG WEN; UNIV AKRON
摘要:In various aspects, embodiments of the present invention are directed to a series of multivalent dendrons containing a bioactive peptide domain and surface-binding catechol domains. In some embodiments, these multivalent dendrons were obtained through solid phase synthesis and have a strong binding affinity to metal oxide surfaces such as, TiO 2 , ZrO 2 , CeO 2 , and Fe 3 O 4 , SiO2, as well as other inorganic surfaces such as hydroxyapatite, silver, fluorapatite, calcium carbonate and gold. These catechol-bearing dendrons provide a fast and efficient method to functionalize a wide range of inorganic materials with bioactive peptides and have the potential to be used in coating orthopaedic implants and fixation devices.