专利号:US-9856251-B2 优先权日:2008-09-03 标题:Substituted berbines and processes for their synthesis 发明人:WANG PETER X; MOSER FRANK W; CANTRELL GARY L; GROTE CHRISTOPHER W 权利人:MALLINCKRODT LLC 摘要:The present invention provides processes for the synthesis of substituted berbine compounds. Also provided are intermediates used in the synthesis of substituted berbine compounds.
专利号:US-9181237-B2 优先权日:2013-10-04 标 题 :Substituted berbines and their synthesis 发明人:GROTE CHRISTOPHER W 权利人:MALLINCKRODT LLC 摘要:The present invention provides substituted berbines, processes for the synthesis of substituted berbine compounds, as well as intermediates used in the synthesis of substituted berbine compounds. Also provided are methods for using the substituted berbines to inhibit cancer cell growth.
专利号:US-2011098466-A1 优先权日:2007-08-31 标题:Synthesis Of Triphenodioxazine Pigments 发明人:KEMPTER PETER; STRECK WILHELM 权利人:CLARIANT FINANCE BVI LTD 摘要:The invention relates to a process for the preparation of compounds of the general formula (I) where X are halogen atoms, the rings labeled A are linearly or angularly fused in position 1,2; 2,3 or 3,4, and in position 8,9; 9,10 or 10,11, to a 5- or 6-membered heterocyclic ring containing in the ring one nitrogen atom and one oxygen atom, or containing in the ring two nitrogen atoms, comprising an oxidation of a 3,6-bisarylamino-2,5-dihalobenzoquinone of the formula (II) in an aprotic-polar organic solvent in the presence of an organic sulfonic acid.
专利号:US-4143050-A 优先权日:1977-01-05 标题 :Manufacture of 3-halosulfonylthiophene-carboxylic acid compounds 发明人:ROSSY PHILLIP A; HOFFMANN WERNER; MUELLER NORBERT 权利人:BASF AG 摘要:3-Halosulfonylthiophene-carboxylic acid compounds are manufactured by reacting 3-ketothiophane-carboxylic acid compounds with sulfonic acid compounds, reacting the end product from the 1st reaction stage with alkali metal polysulfides, reacting the end product from the 2nd stage with a dehydrogenating agent and finally reacting the end product from the 3rd stage with halogen and water. The products are starting compounds for the manufacture of drugs, dyes and crop protection agents and have an anti-inflammatory, analgesic and anti-rheumatic action. In particular, the end products I are starting materials for the manufacture of sweeteners which are non-toxic and free from an after-taste, flavor-improving agents, diabetic aids and feedstuffs, and provide the means of a simple and economical synthesis of thiophene-saccharins.
专利号:US-11780802-B2 优先权日:2017-12-05 标题:Organic sulfonic acid salts of amino acid esters and process for their preparation 发明人:EBERT SOPHIA; LUDOLPH BJOERN; MARCZEWSKI DAWID 权利人:BASF SE 摘要:The application relates to a process for the synthesis of organic sulfonic acid salts of amino acid esters comprising the steps of (i) reacting at least one lactam with at least 3 carbon atoms in the lactam ring with at least one organic sulfonic acid in an aqueous solution, (ii) esterification of the organic sulfonic amino acid salt of step (i) with at least one alcohol with at least 8 carbon atoms comprising at least one hydroxyl group, (iii) optionally removal of water and/or removal of excess alcohol of step (ii). The application also relates to organic sulfonic acid salts of amino acid esters of the general formula (I).
专利号:US-12172982-B2 优先权日:2020-08-12 标 题:Synthesis of quinazoline compounds 发明人:LIM NGIAP-KIE; SHEN JEFF; SIROIS LAUREN ELIZABETH; TIMMERMAN JACOB C; TRACHSEL ETIENNE; WHITE NICHOLAS ANDREW; XU JIE; ZHANG HAIMING; BACHMANN STEPHAN; BIGLER RAPHAEL; CLAGG KYLE BRADLEY PASCUAL; DIPASQUALE ANTONIO GIOVANNI; GOSSELIN FRANCIS; ORCEL UGO JONATHAN; MEIER ROLAND CHRISTOPH 权利人:GENENTECH INC; HOFFMANN LA ROCHE 摘要:Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.