专利号:US-2021284618-A1 优先权日:2016-08-12 标 题 :Furanochalcones as inhibitors of cyp1a1, cyp1a2 and cyp1b1 for cancer chemoprevention 发明人:BHARATE SANDIP BIBISHAN; SHARMA RAJNI; JOSHI PRASHANT; VISHWAKARMA RAM; CHAUDHURI BHABATOSH 权利人:COUNCIL SCIENT IND RES; DE MONTFORT UNIV 摘要:The present invention relates to the furanochalcone class of compounds of general formula A. The present invention particularly relates to the synthesis of furanochalcones and their CYP1A1, CYP1A2 and CYP1B1 inhibitory activity. In addition, the invention relates to the prevention or treatment of cancer caused by polyaromatic hydrocarbons (PAHs), 4-nitroquinoline-1-oxide, and N-nitroso-N-methylurea, heterocyclic amines, estrogen and 17β-estradiol, resulting from the inhibition of CYP1A1, CYP1A2 and CYP1B1 enzymes.
专利号:US-7884125-B2 优先权日:2008-04-30 标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues 发明人:STEVENS CHRISTIAN; HEUGEBAERT THOMAS 权利人:UNIV GENT 摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.
专利号:US-4168280-A 优先权日:1978-05-19 标题 :Method for synthesis of 2-hydroxy-3-methyl cyclopent-2-ene-1-one 发明人:NASH WILLIAM D 权利人:EL PASO PRODUCTS CO 摘要:The known compound 2-hydroxy-3-methyl cyclopent-2-ene-1-one, used as a flavor imparting agent and commonly called maple lactone, is synthesized by a modified acyloin condensation of esters of 2-methyl glutaric acid in which oxygen is introduced in a specific manner to the reaction system.
专利号:US-2015183703-A1 优先权日:2011-03-28 标 题:Synthesis of diacids 发明人:WONG PUI KWAN; LI CHUANZHAO; STUBBS LUDGER; VAN MEURS MARTIN; ANAK KUMBANG DANIEL GAIT; LIM SHARON CHUN YAN; DRENT EITE 权利人:WONG PUI KWAN; LI CHUANZHAO; STUBBS LUDGER; VAN MEURS MARTIN; ANAK KUMBANG DANIEL GAIT; LIM SHARON CHUN YAN; DRENT EITE; AGENCY SCIENCE TECH & RES 摘要:The invention relates to a process for preparing a dicarboxylic acid comprising the steps: (a) heating a lactone in the presence of a first catalyst system to produce an alkenoic acid; and (b) contacting the alkenoic acid with carbon monoxide, water and a second catalyst system to produce a reaction composition comprising the second catalyst system and the dicarboxylic acid.
专利号:US-2009275616-A1 优先权日:2008-04-30 标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
专利号:CN-108101741-A 优先权日:2017-12-05 标题 :A method for the tandem synthesis of chiral alcohols by hydration/asymmetric hydrogenation of alkynes