CAS: 571-60-8; Naphthalene-1,4-Diol

上下游产品

1,4-dioxane ethylene1,1-Bisethylene [1,4]naphthoquinone α-naphthol 1,4-dihydroxy-9,10-anthracenedione 4-methoxynaphth-1-ol 1,4-dimethoxynaphthalene 6,11-dihydroxy-5,12-naphthacenedione

1,4-萘醌置于sodium Tetrahydroborate体系中,用 乙醇,水 作为反应溶剂,化学反应生成 1,4-二羟基萘
参考文献:烷基三苯基膦将萘醌咪唑转化为有效的抗分枝杆菌膜去极化剂
标题:烷基三苯基膦将萘醌咪唑转化为有效的抗分枝杆菌膜去极化剂
摘要:由于其在能量产生和细菌活力中的核心作用,分枝杆菌生物能学是抗结核药物发现的有吸引力的治疗靶点.基于我们对由近端正电荷激活并在 Ii 型 Nadh 脱氢酶还原时产生活性氧的抗分枝杆菌二氧萘并咪唑的研究,我们在此研究了远端正电荷通过掺入三烷基膦阳离子对萘醌咪唑的抗分枝杆菌活性的影响.结构-活性关系研究证实了接头长度的效力增强特性.抗结核分枝杆菌最活跃的化合物h37Rv 在低微摩尔范围内显示出非常好的选择性指数 (Si = 34) 和强杀菌活性,这是通过细菌膜快速去极化导致细胞内 Atp 耗尽而发生的.通过这项工作,我们展示了通过重新定位正电荷来改变支架的作用方式,同时保持其出色的抗菌活性和选择性.
DOI:10.1039/d2Md00251E

专利信息

专利号:US-11912654-B2
优先权日:2021-09-03
标 题:Process for stereospecific synthesis of vitamin K2 and its novel intermediates
发明人：MEHTA DILIP; SHASHTRI MAYANK; RAJU BNS; SHAH ASHWIN; VORA PARIN; MAHALE UMAKANT
权利人:SYNERGIA LIFE SCIENCES PVT LTD
摘要:The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7. The present disclosure further discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.

专利号:WO-2023031841-A1
优先权日:2021-09-03
标题:A process for the stereospecific synthesis of vitamin k2 and its intermediates
发明人：MEHTA DILIP; SHASHTRI MAYANK; RAJU BNS; VORA PARIN; MAHALE UMAKANT
权利人:SYNERGIA LIFE SCIENCES PVT LTD
摘要:The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7, in particular. It also discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.

专利号:US-4061660-A
优先权日:1975-09-29
标 题 :Process for synthesis of coenzyme Q compounds
发明人：KIJIMA SHIZUMASA; YAMATSU ISAO; MINAMI NORIO; INAI YUICHI
权利人:EISAI CO LTD
摘要:A process for the synthesis of 2,3-dimethoxy-5-methyl-6-substituted-1,4-benzoquinones having the formula: ##STR1## wherein R is ##STR2## in which n is an integer of 0 to 9, and A and B are hydrogens or A--B is a direct valence bond between the carbon atoms to which they are attached, n Characterized by reacting 2-methyl-4,5,6-trimethoxyphenol with an aryl boronic acid, a lower alkyl boronic acid or an acid anhydride thereof to obtain a 2-methyl-4,5,6-trimethoxyphenol ester of boric acid, reacting the resulting ester with an n-prenol or iso-prenol having the formula: ##STR3## wherein R is as defined above, OR A REACTIVE DERIVATIVE OF SAID N- OR ISO-PRENOL, IN THE PRESENCE OF A SILICA-ALUMINA COMPOUND, TO OBTAIN A 2-METHYL-3-SUBSTITUTED-4,5,6-TRIMETHOXYPHENOL ESTER OF BORIC ACID, AND HYDROLYZING THE THUS-OBTAINED ESTER AND TREATING THE RESULTING 2-METHYL-3-SUBSTITUTED-4,5,6-TRIMETHOXYPHENOL HAVING THE FORMULA: ##STR4## wherein R is as defined above, WITH AN OXIDIZING AGENT.

专利号:US-6197920-B1
优先权日:1999-07-21
标 题:Formulation for the production of 1, 3-bis (4-aminophenoxy) naphthalene and its polymer
发明人：CHENG KUN LIN; CHEN WEN-TUNG
权利人:CHINA TEXTILE INST
摘要:The present invention relates to the synthesis of new type of diamine monomer, 1,3-bis(4-amonophenoxy)naphthalene, and with such a compound to produce a series of aromatic polymers, including polyamide, polyimide, copoly(amide-imide)s, etc., such polymers having excellent resistance to heat and mechanical properties.

专利号:US-4739062-A
优先权日:1985-07-09
标题:Method of producing paraquinones
发明人：BIGI FRANCA; CASIRAGHI GIOVANNI; CASNATI GIUSEPPE; SARTORI GIOVANNI
权利人:CONSIGLIO NAZIONALE RICERCHE
摘要:A new widely-applicable method has been found for synthesis of 9,10-anthraquinones and similar chemical compounds of wide use in industry and pharmacology, by reacting suitable aromatic substrates with activated dicarboxylic acids (more particularly dichlorides) in the presence of metal halides. The special characteristics of the reaction are the good yields, high selectivity, the possibility of operating in a single reactor and the use of starting compounds which are cheap and easily available on the market.

专利号:US-5753726-A
优先权日:1995-12-20
标 题:Synthesis of modified epoxy resins for cathodic electrodeposition with catalyst deactivation and diol modification
发明人：REUTER HARDY; JOUCK WALTER; OTT GUENTHER
权利人:BASF LACKE & FARBEN
摘要:Epoxy resins for preparing water-dispersible binders for cathodic electrodeposition coating materials, the epoxy resin being preparable by reacting a) polyepoxides having at least one glycidyl group per molecule b) and, optionally, up to 60% by weight, based on the overall epoxy resin reaction product, of aliphatic and/or alicyclic hydroxy compounds having preferably two or on average less than two hydroxyl groups per molecule and a molecular weight of less than 9000 g/mol, c) in the presence of a catalyst consisting of neutral metal salts, such as alkali metal salts and alkaline earth metal salts, zinc salts and nickel salts of tetrafluoroboric, tetrachloroboric, hexafluoro- antimonic,hexachloroantimonic,hexafluorophosphoric, perchlorate and periodic acid, and d) adding a deactivating agent which prevents the epoxy groups reacting further or effectively reduces the rate of such reaction as soon as the phenolic hydroxyl groups have already substantially reacted and at least 0.6% by weight of epoxy groups are still present, based on the overall weight of the epoxy resin reaction product.\\!