CAS: 57041-67-5; Desflurane

上下游产品

CAS号26675-46-7 异氟醚 | CAS号7787-71-5 三氟化溴 | CAS号56885-29-1 1,2,2,2-tetrafl... | CAS号1885-48-9 二氟甲基-2,2,2-三氟乙基醚

1,2,2,2-四氟乙基二氯甲基醚置于potassium Fluoride,18-冠醚-6体系中,用 环丁砜 作为反应溶剂,150.0 °C,400.01 Kpa 条件下,反应 5.0H,以70%的收率获得产物地氟烷
参考文献:1,2,2,2−テトラフルオロエチルジフルオロメチルエーテル(デスフルラン)の製造方法
标题:1,2,2,2−テトラフルオロエチルジフルオロメチルエーテル(デスフルラン)の製造方法
摘要:[问题]提供一种在工业规模下高效制造1,2,2,2-四氟乙基二氟甲基醚(desflurane)的方法. [解决方案]使用易于处理的氟化金属作为氟化试剂,对1,2,2,2-四氟乙基二氯甲基醚进行氟化反应,可以在抑制底物分解的同时高效地得到1,2,2,2-四氟乙基二氟甲基醚(desflurane). [选择图]无.

专利信息

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-6225511-B1
优先权日:1990-10-26
标题 :Synthesis of fluorinated ethers
发明人：CHAMBERS OWEN ROSS; SIMPSON RODERIC NIGEL FRASER
权利人:RHONE POULENC CHEMICALS
摘要:Fluorinated ethers of the formula:wherein R is hydrogen, fluorine, alkyl of 1 to 6 carbon atoms, or fluoroalkyl of 1 to 6 carbon atoms, R' is hydrogen, alkyl of 1 to 6 carbon atoms, or fluoroalkyl of 1 to 6 carbon atoms, and R'' is fluorine, alkyl of 1 to 6 carbon atoms or fluoroalkyl of 1 to 6 carbon atoms are prepared by fluorinating a corresponding ether of formula:with a solid transition metal fluoride fluorinating agent such as cobaltic fluoride.

专利号:US-5205914-A
优先权日:1992-08-14
标题:Synthesis of desflurane
发明人：ROZOV LEONID A; HUANG CHIALANG; VERNICE GERALD G
权利人:ANAQUEST INC
摘要:An improved preparation of desflurane, 1,2,2,2-tetrafluoroethyl difluoromethyl ether utilizing hexafluoropropene epoxide as a starting material. Hexafluoropropene epoxide is advantageous in that it is relatively inexpensive and is environmentally acceptable.

专利号:US-9150480-B2
优先权日:2005-01-12
标题:Synthesis of fluorinated ethers
发明人：SWINSON JOEL; JONES BARRY; GRAHAM DANNY; PAVRI NEVILLE
权利人:SWINSON JOEL; JONES BARRY; GRAHAM DANNY; PAVRI NEVILLE; HALOCARBON PROD CORP
摘要:A process for preparing fluorinated ethers, such as desflurane, comprises reacting the corresponding chlorinated ether, such as isoflurane, with anhydrous hydrogen fluoride in the vapor phase in the presence of chromia catalyst. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader quickly to ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the appended issued claims.

专利号:US-2015352230-A1
优先权日:2013-01-11
标 题:Synthesis and isolation of dendrimer based imaging systems
发明人：MULLEN DOUGLAS GURNETT; BAKER JR JAMES R; BANASZAK HOLL MARK M; HUANG BAOHUA; DOUGHERTY CASEY; BALL JACK
权利人:UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis and isolation of antibodies conjugated with modular dendrimer nanoparticles. In particular, the present invention is directed to antibodies conjugated with novel modular dendrimer nanoparticles having precise numbers of imaging agents, methods of synthesizing the same, compositions comprising such antibodies conjugated with such modular dendrimer nanoparticles, as well as systems and methods utilizing the conjugates (e.g., in imaging settings) (e.g., in diagnostic and/or therapeutic settings) (e.g., for the delivery of therapeutics, imaging, and/or targeting agents).

专利号:US-7605291-B2
优先权日:2006-04-27
标 题 :Method for the preparation of volatile Anesthetics
发明人：MALDONADO ADALBERTO
权利人:MALDONADO ADALBERTO
摘要:The present invention is concerned with the automated control of the synthesis and purification of components useful in the synthesis and purification of volatile anesthetics. The invention is particularly useful in its application to the purification of acetone used in the purification of isoflurane.