CAS: 56951-58-7; (5-Amino-1,3,4-Thiadiazol-2-yl)Methanol

上下游产品

thiosemicarbazide glycolonitrile D-fructose thiosemicarbazone 2-amino-5-formyl-1,3,4-thiadiazole 4-dodecyl-N-(5-(hydroxymethyl)-1,3,4-thiadiazol-2-yl)benzenesulfonamide N-(4-(N-(5-(hydroxymethyl)-1,3,4-thiadiazol-2-yl)sulfamoyl)phenyl)acetamide N-(4-(N-(5-(hydroxymethyl)-1,3,4-thiadiazol-2-yl)sulfamoyl)phenyl)decanamide

📜5-氨基-1,3,4-噻二唑-2-羧酸乙酯置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 作为反应溶剂,以800 Mg的收率获得产物(5-氨基-1,3,4-噻二唑-2-基)甲醇
参考文献: Polq Inhibitor Compound And Use Thereof[fr] Composé Inhibiteur De Polq Et Son Utilisation[zh] Polq抑制剂化合物及其应用
标题: Polq Inhibitor Compound And Use Thereof[fr] Composé Inhibiteur De Polq Et Son Utilisation[zh] Polq抑制剂化合物及其应用
摘要:本发明提供了一种式(I)所示的polq抑制剂化合物或其药学可接受的盐,含有它们的药物组合物以及其在制备预防或者治疗polq介导的疾病的药物中的应用.

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.