CAS: 521-11-9; Mestanolone

上下游产品

17-methyl-5α-androstane-3α,17β-diol (223)C05451ZIN(223)C05451 17-methyltestosterone acetic acid(5S,8R,9S,10S,13S,14S,17S)-17-Hydroxy-10,13,17-trimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthrene-2-carboxylic acid 17-methyl-5α-androstane-3α,17β-diol (223)C05451ZIN(223)C05451 c][1,2,5]oxadiazole17α-methyl-17β-(3-phenyl-propionyloxy)-(5α)-androstano[2,3-c][1,2,5]oxadiazole

📜17Beta-甲基-5Alpha-雄甾烷-3Alpha,17Beta-二醇置于chromium(Vi) Oxide,溶剂黄146体系中,化学反应生成 美雄诺龙
参考文献:性激素x. Herstellung Des 17-甲基睾丸激素与anderer Androsten与androstanderivate.zusammenhängezwischen化学文摘与组织形式hormonwirkung
标题:性激素x. Herstellung Des 17-甲基睾丸激素与anderer Androsten与androstanderivate.zusammenhängezwischen化学文摘与组织形式hormonwirkung
摘要:
DOI:10.1002/hlca.193501801203

专利信息

专利号:US-6448413-B1
优先权日:1999-06-10
标题:Process for the synthesis of a-nor-seco compounds with sterane skeleton
发明人：SANTA CSABA; TUBA ZOLTAN; MAHO SANDOR; SZELES JANOS; BALOGH GABOR; BRLIK JANOS; TRISCHLER FERENC; SZILAGYI GABRIELLA; BAKCSI ERIKA
权利人:RICHTER GEDEON VEGYESZET
摘要:The invention relates to a new process for the synthesis of 17β-hydroxy-17α-methyl-1,3-seco-2-nor-5α-androstane-3-acid derivatives of formula (I) n wherein the meaning of Z is carboxyl or formyl group and n to the new secoindoxylidene carboxylic acid derivatives of formula (II) n wherein R 1 and R 2 independently are C 1 -C 4 alkyl or alkoxy group, hydrogen or halogen atom—which are intermediates for preparing the compounds of formula (I). n The 17β-hydroxy-17α-methyl-1,3-seco-2-nor-5α-androstane-3-acid derivatives of formula (I) are intermediates in the synthesis of oxandrolon (17β-hydroxy-17α-methyl-2-oxa-5α-androstane-3-one), which is used as anabolic in therapy.

专利号:US-6583298-B1
优先权日:1999-06-10
标 题:Process for the synthesis of 17β-hydroxy-17α-methyl-2-oxa-5α-androstane-3-one
发明人：SANTA CSABA; TUBA ZOLTAN; MAHO SANDOR; SZELES JANOS; FERENCZI KATALIN; HORVATH PETER; LANCOS KRISZTINA; MESTER TAMAS; TROMPLER ARPAD
权利人:RICHTER GEDEON VEGYESZET
摘要:The invention relates to a new process for the synthesis of 17β-hydroxy-17α-methyl-2-oxa-5α-androstane-3-one of formula (I). The process according to the invention is as follows: the 17β-hydroxy-17α-ethyl-1,3-seco-2-nor-5α-androstane-1,3-diacid of formula (III) is transformed into the ring-closed 17β-hydroxy-17α-methyl-1,3-seco-2-nor-5α-androstane-1,3-diacid anhydride of formula (II) in an inert solvent or without solvent with a C 2 -C 3 alkan acid anhydride or a substituted carbodiimide of formula R 1 —Nâ•?Câ•?N—R 2 — wherein R 1 and R 2 independently are C 1 -C 6 alkyl group, C 1 -C 6 alkyl group substituted by tertiary or quaternary amino group or 1-3 phenyl group, C 5 -C 6 cycloalkyl group, aryl group substituted by 1-3 methoxy, tertiary amino, nitro, C 1 -C 4 alkyl group or 1-3 halogen atom—and the obtained compound of formula (II) is reduced regioselectively by a complex alkali metal hydride in an inert solvent The new 17β-hydroxy-17α-methyl-1,3-seco-2-nor-5α-androstane-1,3-diacid anhydride of ormula (II) is also the subject of the invention.

专利号:US-2003032817-A1
优先权日:2001-05-15
标题:Process for the synthesis of oxandrolone
发明人：CABAJ JOHN E; KAIRYS DAVID L; ZIZELMAN PAUL M
摘要:A process is disclosed for synthesizing oxandrolone 1 involving the bromination of compound 2 to obtain compound 3, followed by the highly selective de-bromination of compound 3 to obtain compound 4, followed by the oxidation of compound 4 to obtain compound 6, and finally the reduction of compound 6 to obtain oxandrolone 1.

专利号:WO-9412651-A1
优先权日:1992-12-01
标题 :Enzymatic synthesis of sugar alcohol esters
发明人：BARFOED MARTIN; SKAGERLIND JAN PETER
权利人:NOVO NORDISK AS; BARFOED MARTIN; SKAGERLIND JAN PETER
摘要:A method of preparing a compound of the general formula (I): R1-COO-X-O-R2, wherein R1-CO is the acyl group of a carboxylic acid which may be saturated or unsaturated, O-X-O is a saccharide moiety or a sugar alcohol moiety corresponding to a saccharide or a sugar alcohol of the general formula X(OH)¿2?, and R?2¿ is hydrogen, acetyl, or an alkyl group.

专利号:EP-1354593-B1
优先权日:2002-04-08
标题 :use of an extract of a non-photosynthetic filamentous bacterium as an agent for enhancing the endogenous synthesis of superoxide dismutase
发明人：MAHE YANN; MEYBECK ALAIN
权利人:OREAL
摘要:Promoting endogenous production of superoxide dismutase (SOD) comprises the use of an extract (I) of non-photosynthetic, non-fruiting filamentous bacteria in cosmetic, dermatological or pharmaceutical applications. Use of an extract (I) of non-photosynthetic, non-fruiting filamentous bacteria: (1) in a composition based on a cosmetic medium, as an agent for promoting endogenous production of superoxide dismutase (SOD); or (2) for production of a pharmaceutical or dermatological composition for promoting endogenous production of SOD. Independent claim are also included for: (1) a composition comprising a physiological medium containing Vitreoscilla filliformis extract (Ia) and lycopene (specifically at 0.000000001-0.1 wt. %) or a compound having catalase activity and/or a compound having peroxidase activity; and (2) cosmetic treatment methods for treating loss of firmness and/or elasticity of the skin or for treating skin exposed to sunlight, involving application of compositions containing (Ia).

专利号:EP-1194154-B1
优先权日:1999-07-20
标 题:Use of propionic bacteria for producing propionic acid and/or propionates in the colon
发明人：ROUSSEL EDMOND DANIEL; LEGRAND CHARLES GABRIEL; LEGRAND MARC HENRI; ROLAND NATHALIE; BOUGLE DOMINIQUE
权利人:STANDA LAB SA
摘要:The invention concerns the use of propionic bacteria selected according to their low propensity to autolysis and their resistance to bile salts to obtain a current food composition or a dietetic composition of a medicine absorbable by a human or animal, prepared in such a way that the bacteria are well protected at least partially against gastric acidity, containing at least 10<6> cell/grams of said bacteria, capable of stimulating and increasing significantly the synthesis of propionic acid and/or propionate and, as the case may be, acetic acid and/or acetate at the colon by anaerobic bacterial fermentation.