CAS: 52068-30-1; (4-(Benzyloxy)Phenyl)Hydrazine Hydrochloride

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CAS号51388-20-6 4-苄氧基苯胺盐酸盐 | CAS号6373-46-2 4-苄氧基苯胺 | CAS号51145-58-5 4-苄氧基苯肼 | CAS号37033-95-7 5-苄氧基吲哚-2-甲酸乙酯 | CAS号2504-32-7 5-hydroxyindome... | CAS号198479-63-9 3-甲基-5-苄氧基-2-(4... | CAS号41339-61-1 2-(5-苄氧基-1H-吲哚-...

4-苄氧基-1-硝基苯置于盐酸,Tin(II) Chloride Dihdyrate体系中,用 乙醇 作为反应溶剂,化学反应 13.5H,反应生成 4-苄氧基苯肼盐酸盐
参考文献:四氢咔唑衍生物作为潜在降糖药的设计,合成和评价
标题:四氢咔唑衍生物作为潜在降糖药的设计,合成和评价
摘要:基于 Zg02 设计和合成了两个系列的四氢咔唑衍生物,Zg02 是我们之前研究中开发的有前景的候选物.在 Hepg2 细胞系中筛选新制备的化合物的葡萄糖消耗活性.氮杂-四氢咔唑化合物12B显示出最有效的降血糖活性,与溶剂对照相比,葡萄糖消耗增加了 45%,其活性比阳性对照化合物(二甲双胍和 Zg02)高约 1.2 倍.对潜在机制的研究表明,12B可能通过激活 Ampk 途径表现出降血糖活性.代谢稳定性分析表明,12B在来自 Sd 大鼠的人造胃肠液和血浆中均显示出非常好的稳定性.进行了口服葡萄糖耐量试验 (Ogtt),结果进一步证实12B是一种有效的降血糖药.
DOI:10.1016/j.Bioorg.2021.105172

专利信息

专利号:WO-9700244-A1
优先权日:1995-06-19
标题 :Process for parallel synthesis of a non-peptide library
发明人：FRITZ JAMES E; KALDOR STEPHEN W
权利人:LILLY CO ELI; FRITZ JAMES E; KALDOR STEPHEN W
摘要:A process for the sequential preparation of a library of compounds having pharmaceutical usage. The process involves the sequential mixing of solution phase reagents, followed by scavenging of excess unreacted reagents with solid phase scavenging agents. The process is highly iterative and applicable for producing various ureas, thiureas, amides, carbonates and tertiary amines.

专利号:US-7968732-B1
优先权日:2010-09-07
标 题 :Process for the preparation of 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1H-indole
发明人：DIVI MURALI KRISHNA PRASAD; RAO BOLINENI NAGESWARA; SURESH DANDU VENKATA
权利人:DIVIS LAB LTD
摘要:The present invention is related to a process for the preparation of 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1H-Indole (formula-1, a useful intermediate for the synthesis of bazedoxifene) using 4-benzyloxy propiophenone and 4-benzyloxy phenyl hydrazine hydrochloride.