CAS: 454-90-0; 3-(Trifluoromethyl)Anisole

该化合物是一种氟芳香化合物,其特点是苯环上存在一个甲氧基组和一个三氟甲基组,这种结构具有独特的化学特性,包括电子提取效应和稳定性增强,使其在合成有机化学中具有价值;它是制药,农用化学品和特殊材料的多用途中间体,特别是在需要选择性功能化的反应中;三氟甲基组有助于增加脂性与代谢稳定性,而甲氧基组则提供电子生物替代的再活动,其高纯度和一贯性能使其适合于研究和工业工艺的精确应用.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

3-bromo-1-trifluoromethylbenzene sodium methylate 3-chlorotrifluoromethylbenzene 3-methoxyphenyl bromide 4-methoxy-2-(trifluoromethyl)benzaldehyde 2-methoxy-6-(trifluoromethyl)benzaldehyde 4-methoxy-2-(trifluoromethyl)benzoic acid 2-methoxy-6-(trifluoromethyl)benzoic acid

合成工艺路线路线简述

    三氟甲苯置于甲醇,三氯化铁体系中,化学反应生成 3-(三氟甲基)苯甲醚
    参考文献:Mcbee Et Al.,Journal Of The American Chemical Society,1947,Vol. 69,P. 946
    标题:Mcbee Et Al.,Journal Of The American Chemical Society,1947,Vol. 69,P. 946

    海关参考信息

    专利信息


    专利号:WO-2020242329-A1
    优先权日:2019-05-30
    标 题:Diketopyrrolopyrroles having three different substituents as emitters of yellow, orange and red light, and the method of their preparation
    发明人:PIECZYKOLAN MICHAÅ?; GRYKO DANIEL
    权利人:INST CHEMIII ORGANICZNEJ PAN
    摘要:New derivatives of diketopyrrolopyrroles (well-known organic pigments) having three different substituents and a new method of obtaining them have been disclosed. These dyes can be used as highly fluorescent substances with advantageous properties. These compounds can be obtained by the method according to the invention in no more than a four-step synthesis from simple, readily available and cheap substrates.

    专利号:US-12336981-B2
    优先权日:2010-09-03
    标题 :Compounds and compositions for the inhibition of NAMPT
    发明人:BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; DRAGOVICH Peter; GOSSELIN FRANCIS; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; ROTH BRUCE; SMITH CHASE C; WANG ZHONGGUO; YUEN PO-WAI; ZHENG XIAOZHANG
    权利人:VALO HEALTH INC; GENENTECH INC
    摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

    专利号:US-5220074-A
    优先权日:1990-01-25
    标 题:Optically active isoxazole derivatives and intermediates for preparation thereof as well as processes for producing the same
    发明人:TAKAHASHI TAKASHI; SAKAGUCHI KAZUHIKO
    权利人:DAISO CO LTD
    摘要:The present invention relates to novel optically active isoxazole derivatives represented by general formula: ##STR1## which are useful as intermediates for synthesis of prostaglandin and a process for producing the same as well as novel aldehyde compounds represented by general formula: ##STR2## which are intermediates for preparing the compounds [XI] described above and a process for preparation thereof. In the compounds shown by these formulae, R 1 represents an alkyl group or a cycloalkyl group which may have an alkoxy group or a group shown by -Ra-A-B (wherein Ra is an alkyl group; A is a hetero atom or an single bond; and B is an aromatic or hetero ring which may have a substituent(s)); and R 2 and R 3 , which may be the same or different, each represents an aralkyl group, a silyl group or an acyl group.

    专利号:US-5231208-A
    优先权日:1987-06-16
    标 题:Substituted cyclic ketones, substituted cyclic enones, and process for producing the same
    发明人:SATO FUMIE; ARAI KAZUTAKA; MIYAJI KATSUAKI
    权利人:NISSAN CHEMICAL IND LTD
    摘要:The present invention relates to substituted cyclopentanone and cyclohexanone derivatives and substituted cyclopentenone and cyclohexenone derivatives, which are useful as intermediates for pharmaceutical products and agricultural chemicals and especially useful for the synthesis of prostaglandins, and also to a process for producing the same.

    专利号:US-5210201-A
    优先权日:1990-01-25
    标题:Optically active isoxazole derivatives and intermediates for preparation thereof as well as processes for producing the same
    发明人:TAKAHASHI TAKASHI; SAKAGUCHI KAZUHIKO
    权利人:DAISO CO LTD
    摘要:The present invention relates to novel optically active isoxazole derivatives represented by general formula: ##STR1## which are useful as intermediates for synthesis of prostaglandin and a process for producing the same as well as novel aldehyde compounds represented by general formula: ##STR2## which are intermediates for preparing the compounds [XI] described above and a process for preparation thereof. In the compounds shown by these formulae, R 1 represents an alkyl group or a cycloalkyl group which may have an alkoxy group or a group shown by --Ra--A--B (wherein Ra is an alkyl group; A is a hetero atom or an single bond; and B is an aromatic or hetero ring which may have a substituent(s)); and R 2 and R 3 , which may be the same or different, each represents an aralkyl group, a silyl group or an acyl group.

    专利号:US-5227505-A
    优先权日:1987-06-16
    标题:Substituted cyclic ketones, substituted cyclic enones, and process for producing the same
    发明人:SATO FUMIE; ARAI KAZUTAKA; MIYAJI KATSUAKI
    权利人:NISSAN CHEMICAL IND LTD
    摘要:The present invention relates to substituted cyclopentanone and cyclohexanone derivatives and substituted cyclopentenone and cyclohexenone derivatives, which are useful as intermediates for pharmaceutical products and agricultural chemicals and especially useful for the synthesis of prostaglandins, and also to a process for producing the same.
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    合成参考文献


    摘要:Hall, D. G.; Zheng, H., Science of Synthesis Knowledge Updates, (2011) 4, 73.
    摘要:Ros, A.; Fernández, R.; Lassaletta, J. M., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 408.
    摘要:Wu, S.; Song, H.; Hu, M., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 65.
    参考文献:10.1038/ncomms14190
    摘要:Meng Q, Hou M, Liu H, Song J, Han B. Synthesis of ketones from biomass-derived feedstock. Nature Communications. 2017 Jan 31;8(1):14190. doi: 10.1038/ncomms14190.
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