CAS: 41447-16-9; (S)-1-((R)-1-Methylpiperidin-2-yl)Propan-2-Ol
- 英文名称(S)-1-((R)-1-Methylpiperidin-2-yl)Propan-2-Ol
- 中文名称(αS,2R)-α,1-二甲基-2-哌啶乙醇
- IUPAC名称(S)-1-((R)-1-methylpiperidin-2-yl)propan-2-ol
- 其它别名(+)-N-Methylallosedridine; (Alphas,2R)-Alpha,1-Dimethyl-2-Piperidineethanol; 2-Piperidineethanol, α,1-Dimethyl-, (αs,2R)-
- CAS编号41447-16-9
- MFCD编号:MFCD20260569
- 分子式:C9H19NO分子量:157.26
- 产品CID: 1428784
- 产品分类天然产物 → 生物碱
物理性质
MSDS等安全信息
上下游产品
[2R-(2R)]-1-benzyloxycarbonyl-2-(2,3-epoxypropyl)piperidine (2S,2'R)-1-[N(1')-(tert-butoxycarbonyl)piperidin-2'-yl]propan-2-ol (R)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (R)-1-benzyloxycarbonyl-2-(2-propenyl)piperidine合成工艺路线路线简述
- 合成目标产物 (+)-N-Methylallosedridine 主要起始原料 1-Piperidinecarboxylic Acid, 2-[(2R)-2-Oxiranylmethyl]-, Phenylmethyl Ester, (2R)-
- (文献来源)合成步骤主要原料 1-Piperidinecarboxylic Acid, 2-[(2R)-2-Oxiranylmethyl]-, Phenylmethyl Ester, (2R)-
📜(R)-1-Benzyloxycarbonyl-2-(2-Propenyl)Piperidine置于lithium Aluminium Tetrahydride,Hydroquinindine-2,5-Diphenyl-4,6-Pyrimidinediyl Diether体系中,化学反应生成 (+)-N-甲基石榴碱; (Alphas,2R)-Alpha,1-二甲基-2-哌啶乙醇
参考文献:A General Entry To 2-(2-Hydroxyalkyl)Piperidines Via Iterative Asymmetric Dihydroxylation To Cause Enantiomeric Enhancement
标题:A General Entry To 2-(2-Hydroxyalkyl)Piperidines Via Iterative Asymmetric Dihydroxylation To Cause Enantiomeric Enhancement
摘要:Both Enantiomers Of 2-(2-Propenyl)Piperidine (1) (76-88% Ee),Prepared Via The First Ad Of 5-Hexenyl Azide,Underwent The Second Ad To Provide All Of The Four Stereoisomeric 2-(2-Hydroxypropyl)-Piperidines (2) With Enantiomeric Enhancement (>98% Ee). An Asymmetric Synthesis,Starting From 2,Of Several 2-(2-Hydroxyalkyl)Piperidine Alkaloids Are Demonstrated. (C) 1997 Elsevier Science Ltd.
DOI:10.1016/s0040-4039(97)00643-6
海关参考信息
- 2905122000-异丙醇
2905142000-仲丁醇
2921199090-其他无环单胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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主要参考文献
参考标题:A New Synthesis Of All Four Stereoisomers Of 2-(2,3-Dihydroxypropyl)Piperidine Via Iterative Asymmetric Dihydroxylation To Cause Enantiomeric Enhancement. Application To Asymmetric Synthesis Of Naturally Occurring Piperidine-Related Alkaloids作者:Hiroki Takahata,Minoru Kubota,Nobuo Ikota |发布日期:1999.11.1
摘要:Both Enantiomers Of 2-(2-Propenyl)Piperidine 1 (76-88% Ee), Prepared Via The First Asymmetric Dihydroxylation (Ad) Of 5-Hexenyl Azide, Underwent The Second Ad To Provide All Four Of The Stereoisomeric 2-(2,3-Dihydroxypropyl)Piperidines 2 With Enantiomeric Enhancement (>98% Ee). An Asymmetric Synthesis, Starting From 2, Of Several 2-(2-Hydroxyalkyl)Piperidine Alkaloids [(-)-Halosaline, (+)-N-Methylallosedridine, (+)-8-Ethylnorlobelol, (+)-Sedridine, (+)-Allosedridine, (-)-Allosedridine, And (+)-N-Methylsedridine] And The Ant Defense Alkaloids [(+)-Tetraponerine-3 (T-3), T-4, T-7, And T-8] Is Demonstrated.
合成参考文献
参考DOI号:10.1016/S0040-4039(97)00643-6
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