CAS: 37413-91-5; 21-Acetoxypregna-1,4,9(11),16-Tetraene-3,20-Dione

相似化合物

90039-93-3 82423-35-6 23825-05-0

上下游产品

CAS号108-75-8 2,4,6-三甲基吡啶 | CAS号50-24-8 泼尼松龙 | CAS号23460-76-6 21-Hydroxypregn... | CAS号2884-51-7 21-o-acetyl dex...

泼尼松龙置于4-二甲氨基吡啶,氯化亚砜,1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 5.42H,反应生成21-羟基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯
参考文献:利用新的mattox重排法从泼尼松龙合成17Alpha,21-Dihydroxy-9Beta,11Beta-Epoxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate的权宜之计.
标题:利用新的mattox重排法从泼尼松龙合成17Alpha,21-Dihydroxy-9Beta,11Beta-Epoxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate的权宜之计.
摘要:泼尼松龙向17α,21-二羟基-9β,11β-环氧-16α-甲基pregna-1,4-二烯-3,20-Dion 21-乙酸酯的六步转化已实现了13%的未优化收率.确定了影响强的松龙的mattox重排和双重脱水的新条件.还介绍了对硅烷基delta(19,20)-烯醇醚的氧化的增强认识,以及影响氧化成功的结构因素.
Doi:10.1016/j.Steroids.2013.09.008

专利信息

专利号:US-4216159-A
优先权日:1978-05-25
标题 :Synthesis of 16-unsaturated pregnanes from 17-keto steroids
发明人：HESSLER EDWARD J; VANRHEENEN VERLAN H
权利人:UPJOHN CO
摘要:17-Keto steroids (I) in their protected form (IIa or IIb) are reacted with a metalated olefin (VI) to give a 21-aldehyde (IV) which is readily transformed to a 16-unsaturated pregnane (V) which is useful in the production of commercially important substituted corticoids.

专利号:US-4530795-A
优先权日:1984-02-27
标 题 :Process for preparation of 16 α-methyl corticoids from Δ16 -steroids
发明人：HUBER JOEL E
权利人:UPJOHN CO
摘要:This invention discloses a general process for the production of corticoids from respective steroid-type compounds having a double bond from C-16 to C-17. The invention provides a viable alternative synthesis of 17α-hydroxy-progesterones and like corticoids.

专利号:WO-2023016817-A1
优先权日:2021-08-12
标 题:Synthesis of delta 9,11 steroids

专利号:US-2024327451-A1
优先权日:2021-08-12
标 题:Synthesis of Delta 9,11 Steroids

专利号:EP-4384529-A1
优先权日:2021-08-12
标题:Synthesis of delta 9,11 steroids

专利号:CN-117858886-A
优先权日:2021-08-12
标题 :Synthesis of Δ9,11-steroids