CAS: 3674-13-3; Ethyl 2,3-Dibromopropionate

相似化合物

600-05-5 96-13-9 609-11-0

上下游产品

CAS号140-88-5 丙烯酸乙酯 | CAS号623-73-4 重氮乙酸乙酯 | CAS号74-95-3 二溴甲烷 | CAS号64-17-5 乙醇 | CAS号600-05-5 2,3-二溴丙酸 | CAS号41330-13-6 1,1-diethoxycyc... | CAS号4739-94-0 2,3-二氢-1,4-苯并二噁... | CAS号54442-28-3 4-甲基-3,4-二氢-2H-... | CAS号55876-82-9 5-甲基吡啶-2-羧酸乙酯5-... | CAS号34943-06-1 1-苄基环丙胺-2-甲酸乙酯 | CAS号3999-55-1 反式-1,2-环丙烷二甲酸二乙酯 | CAS号598-72-1 2-溴丙酸 | CAS号90729-01-4 1,4-二甲基哌嗪-2-羧酸乙酯 | CAS号14675-44-6 (1,4-二甲基-2-哌嗪基)甲醇 | CAS号220120-57-0 ethyl 5-methyl-... | CAS号220120-59-2 6-氟-3,4-二氢-2H-1...

丙烯酸乙酯置于溴体系中,用 二氯甲烷 用作溶剂,化学反应生成2,3-二溴丙酸乙酯
参考文献:Anionic [4+3] Heteroannulation Of 2-Azidoacrylates: A Modular Synthesis Of 2-Benzazepin-1-Ones
标题:Anionic [4+3] Heteroannulation Of 2-Azidoacrylates: A Modular Synthesis Of 2-Benzazepin-1-Ones
摘要:2-叠氮丙烯酸酯在低温的阴离子条件下与邻苯二甲酸酯发生[4+3]环化反应,生成5-羟基-2-苯并氮杂四环酮,其形成代表了叠氮氮杂环的构建新概念以及2-叠氮丙烯酸酯的新反应性.
Doi:10.1039/c2Cc30279A

专利信息

专利号:US-2006069270-A1
优先权日:2004-09-27
标 题 :Process for the preparation of 1,3,5-trisubstituted pyrazoles via [3+2] cycloaddition
发明人：SHAPIRO RAFAEL; ROSSANO LUCIUS T; TENHUISEN KAREN L
权利人:SHAPIRO RAFAEL; ROSSANO LUCIUS T; TENHUISEN KAREN L
摘要:A process for the preparation of 1,3,5-trisubstituted pyrazole compounds, which are useful intermediates in the synthesis of factor Xa inhibitors.

专利号:US-6825185-B2
优先权日:2000-12-21
标题:Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
发明人：KHANAPURE SUBHASH P; GARVEY DAVID S; EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GASTON RICKY D
权利人:NITROMED INC
摘要:The invention describes novel substituted aryl compounds that are cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or, optionally, at least one therapeutic agent, such as, steroids, nonsterodal antiinflammatory compounds (NSAID), 5-lipoxygenase (5-LO) inhibitors, leukotriene B 4 (LTB 4 ) receptor antagonists, leukotriene A 4 (LTA 4 ) hydrolase inhibitors, 5-HT agonists, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitors, H 2 antagonists, antineoplastic agents, antiplatelet agents, thrombin inhibitors, thromboxane inhibitors, decongestants, diuretics, sedating or non-sedating anti-histamines, inducible nitric oxide synthase inhibitors, opioids, analgesics, Helicobacter pylori inhibitors, proton pump inhibitors, isoprostane inhibitors, and mixtures thereof. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal toxicity or other toxicities; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

专利号:EP-1486498-A1
优先权日:1998-11-23
标 题 :Process and intermediates for growth hormone secretagogues
发明人：CHIU CHARLES KWOK-FUNG; GRIFFITH DAVID ANDREW
权利人:PFIZER PROD INC
摘要:This invention relates to a process for preparing compounds of the Formulan nwherein R 1 , R 2 and Pt are as defined in the specification, which are intermediatesnin the synthesis of certain growth hormone secretagogue compounds. Thisninvention further relates to processes for preparing the growth hormonensecretagogues. The invention also relates to the compound of Formula I whereinnR 1 is H, R 2 is 2,2,2-trifluoromethyl and Pt is Boc.

专利号:US-9708278-B2
优先权日:2013-11-27
标 题 :Substituted 4-benzyl-3,4-dihydro-2H-benzo[B][1,4]oxazine-2-carboxamide analogs as positive allosteric modulators of muscarinic acetycholine receptor M1
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; STAUFFER SHAUN R; PANARESE JOSEPH D
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to N-substituted 3,4-dihydro-benzo[£][1,4]oxazine-2-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-6686471-B2
优先权日:1998-11-23
标 题:Process and intermediates for growth hormone secretagogues
发明人：CHIU CHARLES K; GRIFFITH DAVID A
权利人:PFIZER
摘要:This invention relates to a process for preparing compounds of the Formula I, n wherein R 1 , R 2 and Pt are as defined in the specification, which are intermediates in the synthesis of certain growth hormone secretagogue compounds. This invention further relates to processes for preparing the growth hormone secretagogues. The invention also relates to the compound of Formula I wherein R 1 is H, R 2 is 2,2,2-trifluoromethyl and Pt is Boc.

专利号:EP-1004583-B1
优先权日:1998-11-23
标题:Process and hydantoin intermediates for the synthesis of growth hormone secretagogues