CAS: 325152-98-5; (S)-2-Amino-2-(3-Fluorophenyl)Ethanol
- 英文名称(S)-2-Amino-2-(3-Fluorophenyl)Ethanol
- 中文名称(S)-2-氨基-2-(3-氟苯基)乙醇
- IUPAC名称(S)-2-amino-2-(3-fluorophenyl)ethan-1-ol
- 其它别名(2S)-2-氨基-2-(3-氟苯基)乙醇; Benzeneethanol, Beta-Amino-3-Fluoro-, (Betas)-
- CAS编号325152-98-5
- MFCD编号:MFCD09256370
- 分子式:C8H10FNO分子量:155.17
- 产品CID: 1316182
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
物理性质
MSDS等安全信息
合成工艺路线路线简述
- 合成目标产物 (S)-2-Amino-2-(3-Fluorophenyl)Ethanol 主要起始原料 2-Propanesulfinamide, N-[(1S)-2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-1-(3-Fluorophenyl)Ethyl]-2-Methyl-, [s(R)]-
- (文献来源)合成步骤主要原料 2-Propanesulfinamide, N-[(1S)-2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-1-(3-Fluorophenyl)Ethyl]-2-Methyl-, [s(R)]-
📜间溴氟苯置于titanium(Iv) Isopropylate,盐酸,硼烷四氢呋喃络合物,Magnesium,1,2-二溴乙烷体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应 9.67H,反应生成(S)-2-氨基-2-(3-氟苯基)乙醇
参考文献:A General Asymmetric Synthesis Of Phenylglycinols
标题:A General Asymmetric Synthesis Of Phenylglycinols
摘要:Hydride Reduction And Deprotection Of Siloxymethyl Sulfinimines 2 Reliably Furnished Chiral Phenylglycinols 1 Or 10 In High Overall Yield And Enantiomeric Purity. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetasy.2011.01.011
海关参考信息
- 2902600000-乙苯
2922110001-单乙醇胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11780834-B2
优先权日:2018-06-21
标题:Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3- yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
发明人：CHUNG CHEOL KEUN; XU JIE; IDING HANS; CLAGG KYLE; DALZIEL MICHAEL; FETTES ALEC; GOSSELIN FRANCIS; LIM NGIAP-KIE; MCCLORY ANDREW; ZHANG HAIMING; CHAKRAVARTY PAROMA; NAGAPUDI KARTHIK; ROBINSON SARAH
权利人:HOFFMANN LA ROCHE; GENENTECH INC
摘要:Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.
