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📜5-[(2-Chloro-Phenylamino)-Methylene]-2,2-Dimethyl-[1,3]Dioxane-4,6-Dione置于三氯氧磷体系中,用 二苯醚 用作溶剂,化学反应 3.08H,反应生成4,8-二氯喹啉
参考文献:Synthesis Of Ring-Substituted 4-Aminoquinolines And Evaluation Of Their Antimalarial Activities
标题:Synthesis Of Ring-Substituted 4-Aminoquinolines And Evaluation Of Their Antimalarial Activities
摘要:A Simple Two-Step Synthesis Method Was Used To Make 51 B-Ring-Substituted 4-Hydroxyquinolines Allowing Analysis Of The Effect Of Ring Substitutions On Inhibition Of Growth Of Chloroquine Sensitive And Resistant Strains Of Plasmodium Falciparum,The Dominant Cause Of Malaria Morbidity. Substituted Quinoline Rings Other Than The 7-Chloroquinoline Ring Found In Chloroquine Were Found To Have Significant Activity Against The Drug-Resistant Strain Of P. Falciparum W2. (C) 2004 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2004.12.037

专利信息

专利号:US-2007060558-A1
优先权日:2004-07-30
标 题 :Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents
发明人：SANCHEZ MURIEL; MEUNIER BERNARD
权利人:CENTRE NAT RECH SCIENT
摘要:The invention concerns an aminoquinoline-antibiotic hybrid compound of general formula (I): Q—(Y 1 ) p —(U) p —(Y 2 ) p -A: wherein Q represents an aminoquinoline, (Y 1 ) p (U) p —(Y 2 ) p″ is an optional spacer and A is an antibiotic residue. The invention enables the antibiotic residue activity to be unexpectedly enhanced.