CAS: 183118-10-7; Boron,3-Methyl-1-(3-Methylbutylsulfanyl)Butane

该化合物是一个稳定的borane adtule,通常用作有机合成中的减少剂,其主要优势在于其处理和安全性比自由的borane更强,因为异氨基硫化物在保持活性的同时可以减轻烟火风险.该综合体对于有选择的减少特别有效,包括将boxylic酸转换为酒精和对藻类进行水温调节.其在环境条件下的稳定性使得储存和受控再活性更加容易.此外,异氨基硫化物会提高有机溶剂的溶性,从而便利同质反应条件.这使得该综合体成为需要精确输卵的实验室和工业应用的一个实际选择.

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欧盟法规

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合成工艺路线路线简述

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    专利信息


    专利号:US-2006241298-A1
    优先权日:2005-04-21
    标 题:Methods for synthesis of dicarbamate compounds and intermediates in the formation thereof
    发明人:MORTKO HENRY; HE WEIXUAN; ANDERSEN MARC W; DOTSE ANTHONY K; LI JIE
    权利人:MORTKO HENRY; HE WEIXUAN; ANDERSEN MARC W; DOTSE ANTHONY K; LI JIE
    摘要:Disclosed is a method of making 2-substituted-2-halo-1,3-propanediols via reduction of corresponding malonate compounds. Also disclosed is a method of making 2-substituted-2-halo-1,3-dicarbamate compounds (such as halo derivatives of felbamate, including fluorofelbamate) via reduction of malonate compounds, followed by carbamoylation. Reduction of the malonate compounds is carried out using an electrophilic hydride reagent.

    专利号:US-6204405-B1
    优先权日:1999-12-22
    标 题:Economical and convenient procedures for the synthesis of catecholborane
    发明人:BROWN HERBERT C
    权利人:SIGMA ALDRICH CO
    摘要:New, economical and convenient procedures for the preparation of catecholborane in high chemically pure form using tri-O-phenylene bis borate readily prepared from the reaction of catechol with boric acid, and diborane or borane-Lewis base complexes.

    专利号:WO-2007123900-A2
    优先权日:2006-04-17
    标题:Enantiomers of n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine borane as intermediates in the synthesis of duloxetine

    专利号:EP-1888570-A2
    优先权日:2005-04-21
    标题 :Methods for synthesis of dicarbamate compounds and intermediates in the formation thereof

    专利号:EP-1899317-A2
    优先权日:2006-04-17
    标 题 :Enantiomers of n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine borane as intermediates in the synthesis of duloxetine

    专利号:WO-2006116007-A2
    优先权日:2005-04-21
    标 题:Methods for synthesis of dicarbamate compounds and intermediates in the formation thereof

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